Patents by Inventor Margus Lopp

Margus Lopp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INDOLE-LIKE TRK RECEPTOR ANTAGONISTS
    Publication number: 20170057948
    Abstract: A tropomyosin receptor kinase (Trk) antagonist having a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 is CH3, R2 is OCH3, R3 is SO2N(CH3)2, and R4 is H; or R1 is CH3, R2 is OH, R3 is SO2N(CH3)2, and R4 is H.
    Type: Application
    Filed: August 27, 2016
    Publication date: March 2, 2017
    Inventors: Tonis Timmusk, Margus Lopp, Eero Vasar, Allen Kaasik, Mati Karelson
  • Method for preparation of (2-hydroxy-3-oxo-cyclopent-1-enyl)-acetic acid esters
    Patent number: 8940920
    Abstract: The invention relates to the method of preparation of compounds of formula I, the precursors of homocitric acid lactone and its salts, by coupling of the compounds of formula II with bromoacetic acid esters of formula III.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: January 27, 2015
    Assignee: Tallinn University of Technology
    Inventors: Margus Lopp, Anne Paju, Katharina Matkevit{hacek over (s)}
  • Method for preparation of (2-hydroxy-3-oxo-cyclopent-1-enyl)-acetic acid esters
    Publication number: 20140378698
    Abstract: The invention relates to the method of preparation of compounds of formula I, the precursors of homocitric acid lactone and its salts, by coupling of the compounds of formula II with bromoacetic acid esters of formula III.
    Type: Application
    Filed: June 21, 2013
    Publication date: December 25, 2014
    Inventors: Margus LOPP, Anne PAJU, Katharina MATKEVITÅ MATKEVITÅ
  • Esters of (2-hydroxy-3-oxo-cyclopent-1-enyl) acetic acid and their use for preparing (?)--homocitric acid gamma-lactone, (+)--homocitric acid gamma-lactone and the corresponding (?)--homocitric acid and (+)--homocitric acid salts
    Patent number: 8148568
    Abstract: Archiral (2-hydroxy-3-oxo-cyclopent-1-enyl) acetic acid) alkyl, alkylphenyl and phenyl esters, and a simple and efficient method for the synthesis of both enantiomers of homocitric acid gamma-lactone and the corresponding salts from these esters are described. The method is based on asymmetric oxidation of esters, and the steps of basic and acidic hydrolysis and final acidic lactonization of the homocitric acid into homocitric acid gamma-lactone. The homocitric acid salts are obtained after basic treatment of homocitric acid gamma-lactone. The esters, conditions and reagents used in chemical conversion and separating products are important constituents affording efficient and simple method for production of homocitric acid gamma-lactone and homocitric acid salts.
    Type: Grant
    Filed: May 25, 2007
    Date of Patent: April 3, 2012
    Assignees: Tallinn University of Technology, Cambrex Tallinn AS
    Inventors: Margus Lopp, Anne Paju, Margus Eek, Marit Laos, Tonis Pehk, Raissa Jaalaid
  • ESTERS OF (2-HYDROXY-3-OXO-CYCLOPENT-1-ENYL) ACETIC ACID AND THEIR USE FOR PREPARING (-)-R-HOMOCITRIC ACID GAMMA-LACTONE, (+)-S-HOMOCITRIC ACID GAMMA-LACTONE AND THE CORRESPONDING (-)-R-HOMOCITRIC ACID AND (+)-S-HOMOCITRIC ACID SALTS
    Publication number: 20090187041
    Abstract: Archiral (2-hydroxy-3-oxo-cyclopent-1-enyl) acetic acid) alkyl, alkylphenyl and phenyl esters, and a simple and efficient method for the synthesis of both enantiomers of homocitric acid gamma-lactone and the corresponding salts from these esters are described. The method is based on asymmetric oxidation of esters, and the steps of basic and acidic hydrolysis and final acidic lactonization of the homocitric acid into homocitric acid gamma-lactone. The homocitric acid salts are obtained after basic treatment of homocitric acid gamma-lactone. The esters, conditions and reagents used in chemical conversion and separating products are important constituents affording efficient and simple method for production of homocitric acid gamma-lactone and homocitric acid salts.
    Type: Application
    Filed: May 25, 2007
    Publication date: July 23, 2009
    Applicants: Tallinn University of Technology, AS Vahiuuringute Tehnoloogia Arenduskeskus, Cambrex Tallinn AS
    Inventors: Margus Lopp, Anne Paju, Margus Eek, Marit Laos, Tõnis Pehk, Raissa Jäälaid