Patents by Inventor Mari Valkonen

Mari Valkonen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROTEIN PRODUCTION IN FILAMENTOUS FUNGAL CELLS IN THE ABSENCE OF INDUCING SUBSTRATES
    Publication number: 20220145278
    Abstract: Certain embodiments of the disclosure are directed to variant filamentous fungal cells, compositions thereof and methods thereof for increased production of one or more proteins of interest. More particularly, in certain embodiments, the disclosure is directed to variant filamentous fungal (host) cells derived from parental filamentous fungal cells, wherein the variant host cells comprise a genetic modification which enables the expression/production of a protein of interest (POI) in the absence of inducing substrate. In certain embodiments, a variant fungal host cell of the disclosure comprises a genetic modification which increases the expression of a variant activator of cellulase expression 3 (ace3) gene encoding an Ace3 protein referred to herein as Ace3-L.
    Type: Application
    Filed: November 13, 2020
    Publication date: May 12, 2022
    Inventors: MICHAEL WARD, YUN LUO, FELIPE OSEAS BENDEZU, MARI VALKONEN, MARKKU SALOHEIMO, NINA ARO, TIINA PAKULA
  • Protein production in filamentous fungal cells in the absence of inducing substrates
    Patent number: 10876103
    Abstract: Certain embodiments of the disclosure are directed to variant filamentous fungal cells, compositions thereof and methods thereof for increased production of one or more proteins of interest. More particularly, in certain embodiments, the disclosure is directed to variant filamentous fungal (host) cells derived from parental filamentous fungal cells, wherein the variant host cells comprise a genetic modification which enables the expression/production of a protein of interest (POI) in the absence of inducing substrate. In certain embodiments, a variant fungal host cell of the disclosure comprises a genetic modification which increases the expression of a variant activator of cellulase expression 3 (ace3) gene encoding an Ace3 protein referred to herein as Ace3-L.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: December 29, 2020
    Assignees: DANISCO US INC, VTT TECHNICAL RESEARCH CENTRE OF FINLAND LTD
    Inventors: Michael Ward, Yun Luo, Felipe Oseas Bendezu, Mari Valkonen, Markku Saloheimo, Nina Aro, Tiina Pakula
  • PROTEIN PRODUCTION IN FILAMENTOUS FUNGAL CELLS IN THE ABSENCE OF INDUCING SUBSTRATES
    Publication number: 20190309276
    Abstract: Certain embodiments of the disclosure are directed to variant filamentous fungal cells, compositions thereof and methods thereof for increased production of one or more proteins of interest. More particularly, in certain embodiments, the disclosure is directed to variant filamentous fungal (host) cells derived from parental filamentous fungal cells, wherein the variant host cells comprise a genetic modification which enables the expression/production of a protein of interest (POI) in the absence of inducing substrate. In certain embodiments, a variant fungal host cell of the disclosure comprises a genetic modification which increases the expression of a variant activator of cellulase expression 3 (ace3) gene encoding an Ace3 protein referred to herein as Ace3-L.
    Type: Application
    Filed: October 3, 2017
    Publication date: October 10, 2019
    Inventors: Michael Ward, Yun Luo, Felipe Oseas Bendezu, Mari Valkonen, Markku Saloheimo, Nina Aro, Tiina Pakula