Patents by Inventor Mari Yuasa

Mari Yuasa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TYPE 2 RYANODINE RECEPTOR ACTIVITY INHIBITOR
    Publication number: 20230150952
    Abstract: Providing a RyR2 activity inhibitor having an excellent RyR2 activity inhibitory effect.
    Type: Application
    Filed: February 10, 2021
    Publication date: May 18, 2023
    Applicant: JUNTENDO EDUCATIONAL FOUNDATION
    Inventors: Nagomi Kurebayashi KUNIHIRO, Takashi MURAYAMA, Hiroyuki KAGECHIKA, Shuichi MORI, Mari YUASA, Hiroto IINUMA
  • Cephem compound, its production and its use for producing cephem antibiotics
    Patent number: 5969131
    Abstract: A 3-[(E)-1-propenyl]cephem compound represented by formula (I): ##STR1## wherein R represents hydrogen, a protective group for an amino group, or the group shown by formula (II): ##STR2## in which R.sup.3 is a protective group for an amino group, R.sup.4 is a protective group for a hydroxyl group, and W is --CH.dbd. or --N.dbd.; R.sup.2 represents a protective group for a carboxyl group; and X represents hydrogen or chlorine. The compound is useful as an intermediate for producing cephem antibiotics and is prepared by isomerizing the corresponding 3-[(Z)-1-propenyl]cephem compound in an inert organic solvent in the presence of an aromatic thiol. The compound of formula (I) wherein X is chlorine can be converted into a 3-[(E)-3-ammonio-1-propenyl]cephem derivative through the reaction with a tertiary amine.
    Type: Grant
    Filed: September 18, 1997
    Date of Patent: October 19, 1999
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Mari Yuasa, Kazuyuki Yamagata, Hirokazu Murata, Masashi Komatsu, Isao Yoshida
  • Cephem compound, its production and its use for producing cephem antibiotics
    Patent number: 5708165
    Abstract: A 3-?(E)-1-propenyl!cephem compound represented by formula (I): ##STR1## wherein R represents hydrogen, a protective group for an amino group, or the group shown by formula (II): ##STR2## in which R.sup.3 is a protective group for an amino group, R.sup.4 is a protective group for a hydroxyl group, and W is --CH.dbd. or --N.dbd.; R.sup.2 represents a protective group for a carboxyl group; and X represents hydrogen or chlorine. The compound is useful as an intermediate for producing cephem antibiotics and is prepared by isomerizing the corresponding 3-?(Z)-1-propenyl!cephem compound in an inert organic solvent in the presence of an aromatic thiol. The compound of formula (I) wherein X is chlorine can be converted into a 3-?(E)-3-ammonio-1-propenyl!cephem derivative through the reaction with a tertiary amine.
    Type: Grant
    Filed: July 12, 1994
    Date of Patent: January 13, 1998
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Mari Yuasa, Kazuyuki Yamagata, Hirokazu Murata, Masashi Komatsu, Isao Yoshida