Patents by Inventor Maria A. Peral

Maria A. Peral has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for reducing intraocular pressure using indole derivatives
    Publication number: 20040198803
    Abstract: The present invention provides a method of reducing intraocular pressure by administering pharmaceutical compositions comprising indole derivatives. The pharmaceutical compositions useful in this invention comprise indole derivatives and melatonin analogs of Formulae I-IV. A preferred embodiment is a method of lowering intraocular pressure using 5-(methoxycarbonylamino)-N-acetyltryptamine (5-MCA-NAT), also known as GR 135531, which has a prolonged duration of action and greater efficacy in lowering intraocular pressure compared to melatonin. The present invention further provides a method of treating disorders associated with ocular hypertension, and a method of treating various forms of glaucoma; the method comprises administering an effective dose of a pharmacuetical composition comprising an indole derivative with or without agents commonly used to treat such disorders.
    Type: Application
    Filed: April 20, 2004
    Publication date: October 7, 2004
    Inventors: Jesus J. Pintor, Maria A. Peral, Ward M. Peterson, Robert Plourde, Edward G. Brown, Benjamin R. Yerxa
  • Method for reducing intraocular pressure using indole derivatives
    Patent number: 6730707
    Abstract: The present invention provides a method of reducing intraocular pressure by administering pharmaceutical compositions comprising indole derivatives. The pharmaceutical compositions useful in this invention comprise indole derivatives and melatonin analogs of Formulae I-IV. A preferred embodiment is a method of lowering intraocular pressure using 5-(methoxycarbonylamino)-N-acetyltryptamine (5-MCA-NAT), also known as GR 135531, which has a prolonged duration of action and greater efficacy in lowering intraocular pressure compared to melatonin. The present invention further provides a method of treating disorders associated with ocular hypertension, and a method of treating various forms of glaucoma; the method comprises administering an effective dose of a pharmacuetical composition comprising an indole derivative with or without agents commonly used to treat such disorders.
    Type: Grant
    Filed: July 25, 2001
    Date of Patent: May 4, 2004
    Assignees: Inspire Pharmaceuticals, Inc., Universidad Complutense de Madrid
    Inventors: Jesus J. Pintor, Maria A. Peral, Ward M. Peterson, Robert Plourde, Jr., Edward G. Brown, Benjamin R. Yerxa
  • Method for reducing intraocular pressure using indole derivatives
    Publication number: 20020037887
    Abstract: The present invention provides a method of reducing intraocular pressure by administering pharmaceutical compositions comprising indole derivatives. The pharmaceutical compositions useful in this invention comprise indole derivatives and melatonin analogs of Formulae I-IV. A preferred embodiment is a method of lowering intraocular pressure using 5-(methoxycarbonylamino)-N-acetyltryptamine (5-MCA-NAT), also known as GR 135531, which has a prolonged duration of action and greater efficacy in lowering intraocular pressure compared to melatonin. The present invention further provides a method of treating disorders associated with ocular hypertension, and a method of treating various forms of glaucoma; the method comprises administering an effective dose of a pharmacuetical composition comprising an indole derivative with or without agents commonly used to treat such disorders.
    Type: Application
    Filed: July 25, 2001
    Publication date: March 28, 2002
    Inventors: Jesus J. Pintor, Maria A. Peral, Ward M. Peterson, Robert Plourde, Edward G. Brown, Benjamin R. Yerxa