Abstract: The present invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease characterized by fibrostenosing disease by determining the presence or absence in an individual of a fibrostenosis-predisposing allele linked to a NOD2/CARD15 locus, where the presence of the fibrostenosis-predisposing allele is diagnostic of or predictive of susceptibility to the clinical subtype of Crohn's disease characterized by fibrostenosing disease. In a method of the invention, the clinical subtype of Crohn's disease can be, for example, characterized by fibrostenosing disease independent of small bowel involvement.

Abstract: The principal aim of the present invention is to afford a bioinsecticide dry composition based on entomotoxines of Bacillus thuringiensis var israelensis, which is characterized by its practicability, economy and efficacy in controlling Dipteral insects, being, at the same time, ecologically safe. Thus, the principal objective of this invention is to get a bioinsecticide dry formulation comprising: (a) entomotoxines, pure or not, of Bacillus thuringiensis var israelensis; (b) chemical dryers; (c) dispersing agents; (d) agglutinant/humectant agents; (e) protectors against sunlight; and (f) optionally, diluent, lubricant and neutralizing agents. A first embodiment of this invention is related to a bioinsecticide formulation dispensed as dry powder, or tablets, comprising additives carrying the entomotoxines, pure or not, selected in way to afford a high dispersion of the active component in the application area, but bringing about no risks to the environment.