Patents by Inventor Maria Alexander-Bridges

Maria Alexander-Bridges has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS FOR TREATING OR PREVENTING OBESITY AND INSULIN RESISTANCE DISORDERS
    Publication number: 20170216272
    Abstract: Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
    Type: Application
    Filed: February 3, 2017
    Publication date: August 3, 2017
    Applicants: President and Fellows of Harvard College, The General Hospital Corporation d/b/a Massachusetts General Hospital
    Inventors: David A. Sinclair, Maria Alexander-Bridges
  • Compositions for treating obesity and insulin resistance disorders
    Patent number: 9597347
    Abstract: Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
    Type: Grant
    Filed: August 15, 2014
    Date of Patent: March 21, 2017
    Assignees: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: David A. Sinclair, Maria Alexander-Bridges
  • RGD-BINDING COMPOUNDS AND METHODS OF USE
    Publication number: 20160178615
    Abstract: Provided herein are compositions and methods for preventing and treating diseases and risk factors associated with metabolic syndrome by targeting the RGD-binding site of selected intra- and extracellular proteins. Exemplary compositions include RGD-polyphenol conjugates via an ester linkage; polyphenol polymer conjugated to RGD analogs or mimetics; and RGD polymer conjugates linked to polyphenol.
    Type: Application
    Filed: February 29, 2016
    Publication date: June 23, 2016
    Inventors: MARIA ALEXANDER-BRIDGES, SHAKER A. MOUSA, PAUL J. DAVIS
  • Methods of stimulating fat mobilization using a polymer conjugated polyphenol
    Patent number: 9272049
    Abstract: Provided herein are compositions and methods for preventing and treating diseases and risk factors associated with metabolic syndrome by targeting the RGD-binding site of selected intra- and extracellular proteins. Exemplary compositions include RGD-polyphenol conjugates via an ester linkage; polyphenol polymer conjugated to RGD analogs or mimetics; and RGD polymer conjugates linked to polyphenol.
    Type: Grant
    Filed: June 8, 2011
    Date of Patent: March 1, 2016
    Assignee: NANOPHARMACEUTICALS LLC
    Inventors: Maria Alexander-Bridges, Shaker A. Mousa, Paul J. Davis
  • COMPOSITIONS FOR TREATING OR PREVENTING OBESITY AND INSULIN RESISTANCE DISORDERS
    Publication number: 20150133396
    Abstract: Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
    Type: Application
    Filed: August 15, 2014
    Publication date: May 14, 2015
    Applicants: President and Fellows of Harvard College, The General Hospital Corporation d/b/a Massachusetts General Hospital
    Inventors: David A. Sinclair, Maria Alexander-Bridges
  • Compositions for treating obesity and insulin resistance disorders
    Patent number: 8846724
    Abstract: Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
    Type: Grant
    Filed: July 27, 2011
    Date of Patent: September 30, 2014
    Assignees: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: David A. Sinclair, Maria Alexander-Bridges
  • RGD-BINDING COMPOUNDS AND METHODS OF USE
    Publication number: 20120258069
    Abstract: Provided herein are compositions and methods for preventing and treating diseases and risk factors associated with metabolic syndrome by targeting the RGD-binding site of selected intra- and extracellular proteins. Exemplary compositions include RGD-polyphenol conjugates via an ester linkage; polyphenol polymer conjugated to RGD analogs or mimetics; and RGD polymer conjugates linked to polyphenol.
    Type: Application
    Filed: June 8, 2011
    Publication date: October 11, 2012
    Inventors: Maria Alexander-Bridges, Shaker A. Mousa, Paul J. Davis
  • Method for reducing the weight of a subject or inhibiting weight gain in a subject
    Patent number: 8242171
    Abstract: Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
    Type: Grant
    Filed: January 7, 2010
    Date of Patent: August 14, 2012
    Assignees: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: David A. Sinclair, Maria Alexander-Bridges
  • COMPOSITIONS FOR TREATING OR PREVENTING OBESITY AND INSULIN RESISTANCE DISORDERS
    Publication number: 20120029065
    Abstract: Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
    Type: Application
    Filed: July 27, 2011
    Publication date: February 2, 2012
    Applicants: The General Hospital Corporation d/b/a Massachusetts General Hospital, President and Fellows of Harvard College
    Inventors: David A. Sinclair, Maria Alexander-Bridges
  • Compositions for treating obesity and insulin resistance disorders
    Patent number: 8017634
    Abstract: Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
    Type: Grant
    Filed: July 1, 2005
    Date of Patent: September 13, 2011
    Assignees: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: David A. Sinclair, Maria Alexander-Bridges
  • COMPOSITIONS FOR TREATING OR PREVENTING OBESITY AND INSULIN RESISTANCE DISORDERS
    Publication number: 20100316679
    Abstract: Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
    Type: Application
    Filed: January 7, 2010
    Publication date: December 16, 2010
    Applicants: President and Fellows of Harvard College, The General Hospital Corporation d/b/a Massachusetts General Hospital
    Inventors: David A. Sinclair, Maria Alexander-Bridges
  • Polyphenol Conjugates as RGD-Binding Compounds and Methods of Use
    Publication number: 20100209382
    Abstract: Provided herein are compositions and methods for preventing and treating diseases and risk factors associated with metabolic syndrome by targeting the RGD-binding site of selected intra- and extracellular proteins. Exemplary compositions include RGD-polyphenol conjugates via an ester linkage; polyphenol polymer conjugated to RGD analogs or mimetics; and RGD polymer conjugates linked to polyphenol.
    Type: Application
    Filed: September 18, 2006
    Publication date: August 19, 2010
    Applicant: ORDWAY RESEARCH INSTITUTE, INC.
    Inventors: Maria Alexander-Bridges, Shaker A. Mousa, Paul J. Davis
  • Compositions for treating or preventing obesity and insulin resistance disorders
    Publication number: 20060111435
    Abstract: Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
    Type: Application
    Filed: July 1, 2005
    Publication date: May 25, 2006
    Applicants: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: David Sinclair, Maria Alexander-Bridges
  • Compositions for treating or preventing obesity and insulin resistance disorders
    Publication number: 20050171027
    Abstract: Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
    Type: Application
    Filed: December 29, 2004
    Publication date: August 4, 2005
    Applicants: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: David Sinclair, Maria Alexander-Bridges