Patents by Inventor Maria Alfonso-Jaume

Maria Alfonso-Jaume has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transgenic C57BL6-BTBR mouse with a humanized MHC II gene that expresses GAD65
    Patent number: 11974552
    Abstract: A mouse model that develops type 1 diabetes spontaneously and used thereof are described. In some embodiments, the mouse model expresses a combination of HLA-DQ8 and GAD65 in a C57BL/6-BTBR congenic background, where the GAD65 is expressed under the rat insulin promoter.
    Type: Grant
    Filed: August 2, 2019
    Date of Patent: May 7, 2024
    Assignee: The University of Toledo
    Inventors: Shahnawaz Imam, Maria Alfonso-Jaume, Juan Carlos Jaume
  • Spontaneous Autoimmune Diabetes in Humanized Mice Carrying Human Type 1 Diabetes Susceptibility and Uses Therefor
    Publication number: 20200037586
    Abstract: A mouse model that develops type 1 diabetes spontaneously and used thereof are described. In some embodiments, the mouse model expresses a combination of HLA-DQ8 and GAD65 in a C57BL/6-BTBR congenic background, where the GAD65 is expressed under the rat insulin promoter.
    Type: Application
    Filed: August 2, 2019
    Publication date: February 6, 2020
    Applicant: The University of Toledo
    Inventors: Shahnawaz Imam, Maria Alfonso-Jaume, Juan Carlos Jaume