Patents by Inventor Maria Amelia Escobedo

Maria Amelia Escobedo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitory immunoglobulin polypeptides to human PDGF beta receptor
    Patent number: 7060271
    Abstract: The present invention is directed towards immunoglobulin polypeptides that specifically bind to the extracellular domain of the human type beta PDGF receptor. The binding of the immunoglobulin polypeptides to the receptor inhibits PDGF-induced (or stimulated) receptor activation as indicated by inhibition of receptor phosphorylation and dimerization, and by inhibition of PDGF-mediated mitogenesis, chemotaxis and migration of cells displaying the human PDGF type beta receptor on the cell surface. Nucleic acids encoding the immunoglobulin polypeptides are also included in the invention. The immunoglobulin polypeptides have diagnostic and therapeutic uses.
    Type: Grant
    Filed: January 7, 1998
    Date of Patent: June 13, 2006
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Vanitha Ramakrishnan, Maria Amelia Escobedo, Larry J. Fretto
  • Inhibitory immunoglobulin polypeptides to human PDGF beta receptor
    Publication number: 20030228307
    Abstract: The present invention is directed towards immunoglobulin polypeptides that specifically bind to the extracellular domain of the human type beta PDGF receptor. The binding of the immunoglobulin polypeptides to the receptor inhibits PDGF-induced (or stimulated) receptor activation as indicated by inhibition of receptor phosphorylation and dimerization, and by inhibition of PDGF-mediated mitogenesis, chemotaxis and migration of cells displaying the human PDGF type beta receptor on the cell surface. Nucleic acids encoding the immunoglobulin polypeptides are also included in the invention. The immunoglobulin polypeptides have diagnostic and therapeutic uses.
    Type: Application
    Filed: May 16, 2003
    Publication date: December 11, 2003
    Applicants: COR Therapeutics Inc., Millennium Pharmaceuticals Inc.
    Inventors: Vanitha Ramakrishnan, Maria Amelia Escobedo, Larry J. Fretto
  • INHIBITORY IMMUNOGLOBULIN POLYPEPTIDES TO HUMAN PDGF BETA RECEPTOR
    Publication number: 20030059425
    Abstract: The present invention is directed towards immunoglobulin polypeptides that specifically bind to the extracellular domain of the human type beta PDGF receptor. The binding of the immunoglobulin polypeptides to the receptor inhibits PDGF-induced (or stimulated) receptor activation as indicated by inhibition of receptor phosphorylation and dimerization, and by inhibition of PDGF-mediated mitogenesis, chemotaxis and migration of cells displaying the human PDGF type beta-receptor on the cell surface. Nucleic acids encoding the immunoglobulin polypeptides are also included in the invention. The immunoglobulin polypeptides have diagnostic and therapeutic uses.
    Type: Application
    Filed: January 7, 1998
    Publication date: March 27, 2003
    Inventors: VANITHA RAMAKRISHNAN, MARIA AMELIA ESCOBEDO, LARRY J. FRETTO
  • INHIBITORY IMMUNOGLOBULIN POLYPEPTIDES TO HUMAN PDGF BETA RECEPTOR
    Publication number: 20020009443
    Abstract: The present invention is directed towards immunoglobulin polypeptides that specifically bind to the extracellular domain of the human type beta PDGF receptor. The binding of the immunoglobulin polypeptides to the receptor inhibits PDGF-induced (or stimulated) receptor activation as indicated by inhibition of receptor phosphorylation and dimerization, and by inhibition of PDGF-mediated mitogenesis, chemotaxis and migration of cells displaying the human PDGF type beta receptor on the cell surface. Nucleic acids encoding the immunoglobulin polypeptides are also included in the invention. The immunoglobulin polypeptides have diagnostic and therapeutic uses.
    Type: Application
    Filed: October 15, 1999
    Publication date: January 24, 2002
    Inventors: VANITHA RAMAKRISHMAN, MARIA AMELIA ESCOBEDO, LARRY J. FRETTO
  • Inhibitory immunoglobulin polypeptides to human PDGF beta receptor
    Patent number: 5817310
    Abstract: The present invention is directed towards immunoglobulin polypeptides that specifically bind to the extracellular domain of the human type beta PDGF receptor. The binding of the immunoglobulin polypeptides to the receptor inhibits PDGF-induced (or stimulated) receptor activation as indicated by inhibition of receptor phosphorylation and dimerization, and by inhibition of PDGF-mediated mitogenesis, chemotaxis and migration of cells displaying the human PDGF type beta receptor on the cell surface. Nucleic acids encoding the immunoglobulin polypeptides are also included in the invention. The immunoglobulin polypeptides have diagnostic and therapeutic uses.
    Type: Grant
    Filed: June 10, 1994
    Date of Patent: October 6, 1998
    Assignee: COR Therapeutics, Inc.
    Inventors: Vanitha Ramakrishnan, Maria Amelia Escobedo, Larry J. Fretto, Nathalie Lokker