Patents by Inventor Maria-Ana Ghetie

Maria-Ana Ghetie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for homoconjugates of antibodies which induce growth arrest of apoptosis of tumor cells
    Patent number: 8658168
    Abstract: This invention discloses monoclonal antibodies (MAbs) which have little or no signaling activity as monomers become potent anti-tumor agents when they are converted into homoconjugates. The homoconjugates exert anti-growth activity by signaling G0/G1 arrest or apoptosis, depending upon which cell surface molecule they bind. This activity is specific and does not require an Fc portion. These conjugates are potent, anti-tumor agents.
    Type: Grant
    Filed: April 8, 2002
    Date of Patent: February 25, 2014
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Maria-Ana Ghetie, Jonathan W. Uhr, Ellen S. Vitetta
  • Compositions and methods for homoconjugates of antibodies which induce growth arrest or apoptosis of tumor cells
    Publication number: 20060099213
    Abstract: This invention discloses monoclonal antibodies (MAbs) which have little or no signaling activity as monomers become potent anti-tumor agents when they are converted into homoconjugates. The homoconjugates exert anti-growth activity by signaling G0/G1 arrest or apoptosis, depending upon which cell surface molecule they bind. This activity is specific and does not require an Fc portion. These conjugates are potent, anti-tumor agents.
    Type: Application
    Filed: April 8, 2002
    Publication date: May 11, 2006
    Applicant: Board of Regents, The University of Texas System
    Inventors: Maria-Ana Ghetie, Jonathan Uhr, Ellen Vitetta
  • Compositions and methods for homoconjugates of antibodies which induce growth arrest or apoptosis of tumor cells
    Publication number: 20030165509
    Abstract: This invention discloses monoclonal antibodies (MAbs) which have little or no signaling activity as monomers become potent anti-tumor agents when they are converted into homoconjugates. The homoconjugates exert anti-growth activity by signaling G0/G1 arrest or apoptosis, depending upon which cell surface molecule they bind. This activity is specific and does not require an Fc portion. These conjugates are potent, anti-tumor agents.
    Type: Application
    Filed: April 8, 2002
    Publication date: September 4, 2003
    Applicant: Board of Regents, The University of Texas System
    Inventors: Maria-Ana Ghetie, Jonathan W. Uhr, Ellen S. Vitetta
  • Compositions and methods for homoconjugates of antibodies which induce growth arrest or apoptosis of tumor cells
    Patent number: 6368596
    Abstract: This invention discloses monoclonal antibodies (MAbs) which have little or no signaling activity as monomers become potent anti-tumor agents when they are converted into homoconjugates. The homoconjugates exert anti-growth activity by signaling G0/G1 arrest or apoptosis, depending upon which cell surface molecule they bind. This activity is specific and does not require an Fc portion. These conjugates are potent, anti-tumor agents.
    Type: Grant
    Filed: July 8, 1998
    Date of Patent: April 9, 2002
    Assignee: Board of Regents, The University of Texas System
    Inventors: Maria-Ana Ghetie, Jonathan W. Uhr, Ellen S. Vitetta