Patents by Inventor Maria Angelica Linton

Maria Angelica Linton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cycloalkyl-linked diheterocycle derivatives
    Patent number: 10676471
    Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.
    Type: Grant
    Filed: May 20, 2019
    Date of Patent: June 9, 2020
    Assignee: Pfizer Inc.
    Inventors: Aaron Craig Burns, Michael Raymond Collins, Samantha Elizabeth Greasley, Robert Louis Hoffman, Peter Qinhua Huang, Robert Steven Kania, Pei-Pei Kung, Maria Angelica Linton, Lakshmi Sourirajan Narasimhan, Paul Francis Richardson, Daniel Tyler Richter, Graham Smith
  • Substituted quinazoline and pyridopyrimidine derivatives useful as anticancer agents
    Patent number: 10662204
    Abstract: Compounds of the general formula: processes for the preparation of these compounds, compositions containing these compounds, and administration of these compounds to patients to treat pancreatic, lung, colon and other cancers.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: May 26, 2020
    Assignee: Pfizer Inc.
    Inventors: Simon Planken, Hengmiao Cheng, Michael Raymond Collins, Jillian Elyse Spangler, Alexei Brooun, Andreas Maderna, Cynthia Palmer, Maria Angelica Linton, Asako Nagata, Ping Chen
  • Tetrahydroquinazoline derivatives useful as anticancer agents
    Patent number: 10590115
    Abstract: Compounds of the general formula: processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: March 17, 2020
    Assignee: Pfizer Inc.
    Inventors: Simon Planken, Hengmiao Cheng, Michael Raymond Collins, Jillian Elyse Spangler, Alexei Brooun, Andreas Maderna, Cynthia Palmer, Maria Angelica Linton, Asako Nagata, Ping Chen
  • Cycloalkyl-Linked Diheterocycle Derivatives
    Publication number: 20190270737
    Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.
    Type: Application
    Filed: May 20, 2019
    Publication date: September 5, 2019
    Applicant: Pfizer Inc.
    Inventors: Aaron Craig Burns, Michael Raymond Collins, Samantha Elizabeth Greasley, Robert Louis Hoffman, Peter Qinhua Huang, Robert Steven Kania, Pei-Pei Kung, Maria Angelica Linton, Lakshmi Sourirajan Narasimhan, Paul Francis Richardson, Daniel Tyler Richter, Graham Smith
  • Tetrahydroquinazoline Derivatives Useful as Anticancer Agents
    Publication number: 20190248767
    Abstract: Compounds of the general formula: processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
    Type: Application
    Filed: February 1, 2019
    Publication date: August 15, 2019
    Applicant: PFIZER INC.
    Inventors: Simon PLANKEN, Hengmiao CHENG, Michael Raymond COLLINS, Jillian Elyse SPANGLER, Alexei BROOUN, Andreas MADERNA, Cynthia PALMER, Maria Angelica LINTON, Asako NAGATA, Ping CHEN
  • Substituted Quinazoline and Pyridopyrimidine Derivatives Useful as Anticancer Agents
    Publication number: 20190233440
    Abstract: Compounds of the general formula: processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
    Type: Application
    Filed: January 31, 2019
    Publication date: August 1, 2019
    Applicant: PFIZER INC.
    Inventors: Simon PLANKEN, Hengmiao CHENG, Michael Raymond COLLINS, Jillian Elyse SPANGLER, Alexei BROOUN, Andreas MADERNA, Cynthia PALMER, Maria Angelica LINTON, Asako NAGATA, Ping CHEN
  • Cycloalkyl-Linked Diheterocycle Derivatives
    Publication number: 20190040055
    Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.
    Type: Application
    Filed: October 11, 2018
    Publication date: February 7, 2019
    Applicant: Pfizer Inc.
    Inventors: Aaron Craig Burns, Michael Raymond Collins, Samantha Elizabeth Greasley, Robert Louis Hoffman, Peter Qinhua Huang, Robert Steven Kania, Pei-Pei Kung, Maria Angelica Linton, Lakshmi Sourirajan Narasimhan, Paul Francis Richardson, Daniel Tyler Richter, Graham Smith
  • Cycloalkyl-linked diheterocycle derivatives
    Patent number: 10125130
    Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: November 13, 2018
    Assignee: Pfizer Inc.
    Inventors: Aaron Craig Burns, Michael Raymond Collins, Samantha Elizabeth Greasley, Robert Louis Hoffman, Peter Qinhua Huang, Robert Steven Kania, Pei-Pei Kung, Maria Angelica Linton, Lakshmi Sourirajan Narasimhan, Paul Francis Richardson, Daniel Tyler Richter, Graham Smith
  • Cycloalkyl-Linked Diheterocycle Derivatives
    Publication number: 20180148441
    Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.
    Type: Application
    Filed: November 29, 2017
    Publication date: May 31, 2018
    Applicant: PFIZER INC.
    Inventors: Aaron Craig BURNS, Michael Raymond COLLINS, Samantha Elizabeth GREASLEY, Robert Louis Hoffman, Peter Qinhua HUANG, Robert Steven Kania, Pei-Pei KUNG, Maria Angelica LINTON, Lakshmi Sourirajan NARASIMHAN, Paul Francis RICHARDSON, Daniel Tyler RICHTER, Graham SMITH
  • Axl inhibitors
    Patent number: 9593097
    Abstract: Compounds of the general formula (I): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: March 14, 2017
    Assignee: Pfizer Inc.
    Inventors: Ted William Johnson, Paul Francis Richardson, Michael Raymond Collins, Daniel Tyler Richter, Benjamin Joseph Burke, Sacha Ninkovic, Ketan Satish Gajiwala, Maria Angelica Linton, Phuong Thi Quy Le, Jacqui Elizabeth Hoffman
  • Cycloalkyl-Linked Diheterocycle Derivatives
    Publication number: 20170050958
    Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.
    Type: Application
    Filed: April 17, 2015
    Publication date: February 23, 2017
    Applicant: PFIZER INC.
    Inventors: Aaron Craig BURNS, Michael Raymond COLLINS, Samantha Elizabeth GREASLEY, Robert Louis Hoffman, Peter Qinhua HUANG, Robert Steven Kania, Pei-Pei KUNG, Maria Angelica LINTON, Lakshmi Sourirajan NARASIMHAN, Paul Francis RICHARDSON, Daniel Tyler RICHTER, Graham SMITH
  • AXL INHIBITORS
    Publication number: 20160176850
    Abstract: Compounds of the general formula (I): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
    Type: Application
    Filed: December 14, 2015
    Publication date: June 23, 2016
    Inventors: Ted William Johnson, Paul Francis Richardson, Michael Raymond Collins, Daniel Tyler Richter, Benjamin Joseph Burke, Sacha Ninkovic, Ketan Satish Gajiwala, Maria Angelica Linton, Phuong Thi Quy Le, Jacqui Elizabeth Hoffman
  • Pyrazole compounds as RAF inhibitors
    Patent number: 7772246
    Abstract: The present invention is directed to compounds of Formula (I), and to pharmaceutically acceptable salts thereof, their synthesis, and their use as Raf inhibitors.
    Type: Grant
    Filed: July 30, 2008
    Date of Patent: August 10, 2010
    Assignee: Pfizer Inc.
    Inventors: Jingrong Jean Cui, Judith Gail Deal, Danlin Gu, Chuangxing Guo, Mary Catherine Johnson, Robert Steven Kania, Susan Elizabeth Kephart, Maria Angelica Linton, Indrawan James McAlpine, Mason Alan Pairish, Cynthia Louise Palmer
  • PYRAZOLE COMPOUNDS
    Publication number: 20090221608
    Abstract: The present invention is directed to compounds of Formula (I), and to pharmaceutically acceptable salts thereof, their synthesis, and their use as Raf inhibitors.
    Type: Application
    Filed: July 30, 2008
    Publication date: September 3, 2009
    Inventors: Jingrong Jean Cui, Judith Gail Deal, Danlin Gu, Chuangxing Guo, Mary Catherine Johnson, Robert Steven Kania, Susan Elizabeth Kephart, Maria Angelica Linton, Indrawan James McAlpine, Mason Alan Pairish, Cynthia Louise Palmer
  • Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same
    Patent number: 7473790
    Abstract: The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R1 and R2, are as defined herein. The invention also relates to methods of treating Hepatitis C virus in mammals by administering the compounds of formula 1, and to pharmaceutical compositions for treating such disorders, which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
    Type: Grant
    Filed: May 8, 2006
    Date of Patent: January 6, 2009
    Assignee: Pfizer Inc.
    Inventors: Allen Borchardt, Javier Gonzalez, Hui Li, Maria Angelica Linton, John Howard Tatlock
  • HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
    Patent number: 7179918
    Abstract: Compounds of the formula: where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.
    Type: Grant
    Filed: June 11, 2002
    Date of Patent: February 20, 2007
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Stacie S. Canan Koch, Therese N. Alexander, Benjamin J. Burke, Tanya M. Jewell, David J. Kucera, Maria Angelica Linton, Lennert J. Mitchell, Jr., Siegfried H. Reich, Donald J. Skalitzky, John H. Tatlock, Michael D. Varney, Scott C. Virgil, Stephen E. Webber, Stephen T. Worland, Mark Barvian, Gary Bolton, Frederick Earl Boyer, Jr., Jeffrey J. Machak, Tod Holler, Sean T. Murphy, Michael Melnick, Vara Prasad Josyula
  • Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same
    Patent number: 7148226
    Abstract: The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R1 and R2, are as defined herein. The invention also relates to methods of treating Hepatitis C virus in mammals by administering the compounds of formula 1, and to pharmaceutical compositions for treating such disorders, which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
    Type: Grant
    Filed: November 19, 2003
    Date of Patent: December 12, 2006
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Allen Borchardt, Javier Gonzalez, Hui Li, Maria Angelica Linton, John Howard Tatlock
  • Inhibitors of hepatitis C virus RNA-dependent RNA polymerase
    Patent number: 7115658
    Abstract: Compounds of formula I are hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) inhibitors, and are useful in therapeutic and prophylactic treatment of persons infected with hepatitis C virus
    Type: Grant
    Filed: May 9, 2003
    Date of Patent: October 3, 2006
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Allen J. Borchardt, Peter Scott Dragovich, Javier Gonzalez, Tanya Michelle Jewell, Hui Li, Maria Angelica Linton, John Howard Tatlock, Ru Zhou, Thomas Jay Prins, Melwyn A. Abreo
  • HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
    Patent number: 6953858
    Abstract: Compounds of the formula: where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.
    Type: Grant
    Filed: June 11, 2002
    Date of Patent: October 11, 2005
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Stacie S. Canan Koch, Therese N. Alexander, Mark Barvian, Gary Bolton, Frederick Earl Boyer, Jr., Benjamin J. Burke, Tod Holler, Tanya M. Jewell, Vara Prasad Josyula, David J. Kucera, Maria Angelica Linton, Jeffrey J. Machak, Lennert J. Mitchell, Jr., Sean T. Murphy, Siegfried H. Reich, Donald J. Skalitzky, John H. Tatlock, Michael D. Varney, Scott C. Virgil, Stephen E. Webber, Stephen T. Worland, Michael Melnick
  • Pharmaceutical compositions and methods for their use
    Publication number: 20040224960
    Abstract: The present invention relates to pharmaceutical compositions and to methods for their use in decreasing cytochrome P450 (CYP450) enzyme activity. The present invention also relates to methods of increasing the bioavailability of a compound in a mammal. Additionally, the present invention relates to methods of decreasing the metabolism of certain compounds in a mammal that are metabolized by the cytochrome P450 enzyme. Furthermore, the present invention relates to pharmaceutical compositions comprising at least one compound metabolized by at least one cytochrome P450 enzyme and a cytochrome P450 enzyme-inhibiting amount of a compound of formula (I).
    Type: Application
    Filed: February 17, 2004
    Publication date: November 11, 2004
    Applicant: Agouron Pharmaceuticals, Inc.
    Inventors: Allen J. Borchardt, Peter Scott Dragovich, Javier Gonzalez, Hui Li, Maria Angelica Linton, John Howard Tatlock