Patents by Inventor Maria Aurelia RICCI

Maria Aurelia RICCI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for detecting cells
    Patent number: 10564167
    Abstract: The present invention relates to methods for detecting the chromatin state of a cell based on recording a super resolution image of nucleosome organization and correlating said imaged with size of nucleosomal clutches, nucleosomal density and/or number of nucleosomes per nucleosomal clutches. Additionally, the invention relates to a kit comprising a first antibody capable of specifically binding to a histone protein and a photoswitchable fluorophore linked-secondary antibody and the use of the kit of the invention for detecting the chromatin state of a cell and isolating a cell in an open chromatin state or in a closed chromatin state. The invention also relates to a device adapted to detect the chromatin state of a cell.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: February 18, 2020
    Assignees: FUNDACIÓ INSTITUT DE CIÈNCIES FOTÓNEQUES, FUNDACIÓ CENTRE DE REGULACIÓ GENÒMICA, INSTITUCIÓ CATALANA DE RECERCA↑ESTUDIS AVANçATS
    Inventors: Melike Lakadamyali, Carlo Manzo, Maria Aurelia Ricci, Maria Pia Cosma
  • METHOD FOR DETECTING CELLS
    Publication number: 20170299610
    Abstract: The present invention relates to methods for detecting the chromatin state of a cell based on recording a super resolution image of nucleosome organization and correlating said imaged with size of nucleosomal clutches, nucleosomal density and/or number of nucleosomes per nucleosomal clutches. Additionally, the invention relates to a kit comprising a first antibody capable of specifically binding to a histone protein and a photoswitchable fluorophore linked-secondary antibody and the use of the kit of the invention for detecting the chromatin state of a cell and isolating a cell in an open chromatin state or in a closed chromatin state. The invention also relates to a device adapted to detect the chromatin state of a cell.
    Type: Application
    Filed: September 10, 2015
    Publication date: October 19, 2017
    Inventors: Melike LAKADAMYALI, Carlo MANZO, Maria Aurelia RICCI, Maria Pia COSMA
  • METHOD FOR DETECTING CELLS
    Publication number: 20160069903
    Abstract: The present invention relates to methods for detecting the chromatin state of a cell based on recording a super resolution image of nucleosome organization and correlating said imaged with size of nucleosomal clutches, nucleosomal density and/or number of nucleosomes per nucleosomal clutches. Additionally, the invention relates to a kit comprising a first antibody capable of specifically binding to a histone protein and a photo switchable fluorophore linked-secondary antibody and the use of the kit of the invention for detecting the chromatin state of a cell and isolating a cell in an open chromatin state or in a close chromatin state. The invention also relates to a device adapted to detect the chromatin state of a cell.
    Type: Application
    Filed: September 10, 2014
    Publication date: March 10, 2016
    Inventors: Melike LAKADAMYALI, Carlo MANZO, Maria Aurelia RICCI, Maria Pia COSMA