Patents by Inventor Maria C. Roque-Biewer

Maria C. Roque-Biewer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SPECTRAL CALIBRATION OF FLUORESCENT POLYNUCLEOTIDE SEPARATION APPARATUS
    Publication number: 20100096548
    Abstract: The invention relates to methods, compositions, and systems for calibrating a fluorescent polynucleotide separation apparatus. One aspect of the invention is multiple color calibration standards and their use. A multiple color calibration standard is a mixture of at least two polynucleotides of different length, wherein each of the polynucleotides is labeled with a spectrally distinct fluorescent dye. Another aspect of the invention is to produce total emission temporal profiles of multiple color calibration standards for use in calibrating fluorescent polynucleotide separation apparatus. The peaks corresponding to the fluorescently labeled polynucleotides in the total emission temporal profile may be detected using a peak detector that is driven by changes in the slopes of the total emission temporal profile.
    Type: Application
    Filed: December 22, 2009
    Publication date: April 22, 2010
    Applicant: Applied Biosystems, LLC
    Inventors: Muhammad A. Sharaf, Maria C. Roque-Biewer
  • Spectral calibration of fluorescent polynucleotide separation apparatus
    Patent number: 6991712
    Abstract: The invention relates to methods, compositions, and systems for calibrating a fluorescent polynucleotide separation apparatus. One aspect of the invention is multiple color calibration standards and their use. A multiple color calibration standard is a mixture of at least two polynucleotides of different length, wherein each of the polynucleotides is labeled with a spectrally distinct fluorescent dye. Another aspect of the invention is to produce total emission temporal profiles of multiple color calibration standards for use in calibrating fluorescent polynucleotide separation apparatus. The peaks corresponding to the fluorescently labeled polynucleotides in the total emission temporal profile may be detected using a peak detector that is driven by changes in the slopes of the total emission temporal profile.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: January 31, 2006
    Assignee: Applera Corporation
    Inventors: Muhammad A. Sharaf, Maria C. Roque-Biewer
  • Spectral calibration of fluorescent polynucleotide separation apparatus
    Patent number: 6821402
    Abstract: The invention relates to methods, compositions, and systems for calibrating a fluorescent polynucleotide separation apparatus. One aspect of the invention is multiple color calibration standards and their use. A multiple color calibration standard is a mixture of at least two polynucleotides of different length, wherein each of the polynucleotides is labeled with a spectrally distinct fluorescent dye. Another aspect of the invention is to produce total emission temporal profiles of multiple color calibration standards for use in calibrating fluorescent polynucleotide separation apparatus. The peaks corresponding to the fluorescently labeled polynucleotides in the total emission temporal profile may be detected using a peak detector that is driven by changes in the slopes of the total emission temporal profile.
    Type: Grant
    Filed: September 16, 1998
    Date of Patent: November 23, 2004
    Assignee: Applera Corporation
    Inventors: Muhammad A. Sharaf, Maria C. Roque-Biewer
  • Spectral calibration of fluorescent polynucleotide separation apparatus
    Publication number: 20040195101
    Abstract: The invention relates to methods, compositions, and systems for calibrating a fluorescent polynucleotide separation apparatus.
    Type: Application
    Filed: April 22, 2004
    Publication date: October 7, 2004
    Inventors: Muhammad A. Sharaf, Maria C. Roque-Biewer
  • Spectral calibration of fluorescent polynucleotide separation apparatus
    Publication number: 20020125136
    Abstract: The invention relates to methods, compositions, and systems for calibrating a fluorescent polynucleotide separation apparatus. One aspect of the invention is multiple color calibration standards and their use. A multiple color calibration standard is a mixture of at least two polynucleotides of different length, wherein each of the polynucleotides is labeled with a spectrally distinct fluorescent dye. Another aspect of the invention is to produce total emission temporal profiles of multiple color calibration standards for use in calibrating fluorescent polynucleotide separation apparatus. The peaks corresponding to the fluorescently labeled polynucleotides in the total emission temporal profile may be detected using a peak detector that is driven by changes in the slopes of the total emission temporal profile.
    Type: Application
    Filed: August 10, 2001
    Publication date: September 12, 2002
    Inventors: Muhammad A. Sharaf, Maria C. Roque-Biewer