Patents by Inventor Maria Casillas Holen

Maria Casillas Holen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9433371
    Abstract: Virtual dipole signal amplification for in-body devices, such as implantable and ingestible devices, is provided. Aspects of the in-body deployable antennas of the invention include antennas configured to go from a first configuration to a second configuration following placement in a living body, e.g., via ingestion or implantation. Embodiments of the in-body devices are configured to emit a detectable signal upon contact with a target physiological site. Also provided are methods of making and using the devices of the invention.
    Type: Grant
    Filed: January 22, 2014
    Date of Patent: September 6, 2016
    Assignee: Proteus Digital Health, Inc.
    Inventors: Hooman Hafezi, Benedict Costello, Timothy Robertson, Maria Casillas Holen
  • Patent number: 9320455
    Abstract: Ingestible event markers having high reliability are provided. Aspects of the ingestible event markers include a support, a control circuit, a first electrochemical material, a second electrochemical material and a membrane. In addition, the ingestible event markers may include one or more components that impart high reliability to the ingestible event marker. Further, the ingestible event markers may include an active agent. In some aspects, the active agent, such as a pharmaceutically active agent or a diagnostic agent may be associated with the membrane.
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: April 26, 2016
    Assignee: Proteus Digital Health, Inc.
    Inventors: Hooman Hafezi, Kityee Au-Yeung, Robert Duck, Maria Casillas Holen, Timothy Robertson, Benedict James Costello
  • Patent number: 8961412
    Abstract: Virtual dipole signal amplification for in-body devices, such as implantable and ingestible devices, is provided. Aspects of the in-body deployable antennas of the invention include antennas configured to go from a first configuration to a second configuration following placement in a living body, e.g., via ingestion or implantation. Embodiments of the in-body devices are configured to emit a detectable signal upon contact with a target physiological site. Also provided are methods of making and using the devices of the invention.
    Type: Grant
    Filed: September 25, 2008
    Date of Patent: February 24, 2015
    Assignee: Proteus Digital Health, Inc.
    Inventors: Hooman Hafezi, Benedict James Costello, Timothy L. Robertson, Maria Casillas Holen
  • Patent number: 8951234
    Abstract: Pharmaceutical delivery systems for delivering dosages according to the present invention include a carrier component and a cap configured to seal an internal volume of the carrier component, wherein the cap includes a device that produces a unique current signature. Dosages prepared to be delivered according to embodiments of the invention find use in a variety of different applications, including clinical trials.
    Type: Grant
    Filed: July 2, 2013
    Date of Patent: February 10, 2015
    Assignee: Proteus Digital Health, Inc.
    Inventors: Hooman Hafezi, Gregory Moon, Kityee Au-Yeung, Robert Duck, Maria Casillas Holen
  • Publication number: 20140309504
    Abstract: Virtual dipole signal amplification for in-body devices, such as implantable and ingestible devices, is provided. Aspects of the in-body deployable antennas of the invention include antennas configured to go from a first configuration to a second configuration following placement in a living body, e.g., via ingestion or implantation. Embodiments of the in-body devices are configured to emit a detectable signal upon contact with a target physiological site. Also provided are methods of making and using the devices of the invention.
    Type: Application
    Filed: January 22, 2014
    Publication date: October 16, 2014
    Applicant: Proteus Digital Health, Inc.
    Inventors: Hooman Hafezi, Benedict Costello, Timothy Robertson, Maria Casillas Holen
  • Publication number: 20140046147
    Abstract: Pharmaceutical delivery systems for delivering dosages according to the present invention include a carrier component and a cap configured to seal an internal volume of the carrier component, wherein the cap includes a device that produces a unique current signature. Dosages prepared to be delivered according to embodiments of the invention find use in a variety of different applications, including clinical trials.
    Type: Application
    Filed: July 2, 2013
    Publication date: February 13, 2014
    Applicant: Proteus Digital Health, Inc.
    Inventors: Hooman Hafezi, Gregory Moon, Kityee Au-Yeung, Robert Duck, Maria Casillas Holen
  • Patent number: 8597186
    Abstract: Pharmaceutical delivery systems for delivering dosages according to the present invention include a carrier component and a cap configured to seal an internal volume of the carrier component, wherein the cap includes a device that produces a unique current signature. Dosages prepared to be delivered according to embodiments of the invention find use in a variety of different applications, including clinical trials.
    Type: Grant
    Filed: January 5, 2010
    Date of Patent: December 3, 2013
    Assignee: Proteus Digital Health, Inc.
    Inventors: Hooman Hafezi, Gregory Moon, Kityee Au-Yeung, Robert Duck, Maria Casillas Holen
  • Publication number: 20120011699
    Abstract: High-throughput ingestible event marker manufacturing systems are provided. The systems include an assembly unit configured to stably associate an ingestible event marker with a carrier to produce a product. Also provided are manufacturing methods to produce such products which include assembling an ingestible event marker with an assembly unit configured to stably associate an ingestible event marker with a carrier.
    Type: Application
    Filed: January 5, 2010
    Publication date: January 19, 2012
    Inventors: Hooman Hafezi, Mark Zdeblick, Kityee Au-Yeung, Gregory Moon, Robert Duck, Maria Casillas Holen, Timothy Robertson, Eric Snyder, Mauro Folena, Benedict J. Costello, Pratish Rao
  • Publication number: 20110306852
    Abstract: Pharmaceutical delivery systems for delivering dosages according to the present invention include a carrier component and a cap configured to seal an internal volume of the carrier component, wherein the cap includes a device that produces a unique current signature. Dosages prepared to be delivered according to embodiments of the invention find use in a variety of different applications, including clinical trials.
    Type: Application
    Filed: January 5, 2010
    Publication date: December 15, 2011
    Inventors: Hooman Hafezi, Gregory Moon, Kityee Au-Yeung, Robert Duck, Maria Casillas Holen
  • Publication number: 20090082645
    Abstract: Virtual dipole signal amplification for in-body devices, such as implantable and ingestible devices, is provided. Aspects of the in-body deployable antennas of the invention include antennas configured to go from a first configuration to a second configuration following placement in a living body, e.g., via ingestion or implantation. Embodiments of the in-body devices are configured to emit a detectable signal upon contact with a target physiological site. Also provided are methods of making and using the devices of the invention.
    Type: Application
    Filed: September 25, 2008
    Publication date: March 26, 2009
    Inventors: Hooman Hafezi, Benedict James Costello, Timothy L. Robertson, Maria Casillas Holen