Patents by Inventor Maria Chiu

Maria Chiu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Directed complementation
    Publication number: 20060228302
    Abstract: A method of producing a tumorigenic mouse cell, the tumorigenicity of which depends on a recombinant gene of interest is disclosed. The method involves: (a) providing a conditionally tumorigenic mouse cell containing a recombinant oncogene operably linked to an inducible promoter, wherein (i) expression of the recombinant oncogene is necessary and sufficient for the tumorigenicity of the tumorigenic mouse cell, and (ii) the inducible promoter is in the uninduced state; and (b) introducing into the cell a recombinant gene of interest that functionally complements the oncogene, thereby restoring tumorigenicity without expression of the inducible recombinant oncogene. Also disclosed is a method of testing a compound for anti-tumor effects.
    Type: Application
    Filed: April 5, 2006
    Publication date: October 12, 2006
    Inventors: Murray Robinson, Ronan O'Hagan, Karuppiah Kannan, Ti Cai, Maria Chiu, Lorena Lerner, Jie Lin, Yinghui Zhou
  • Immunosuppressant target proteins
    Publication number: 20050059803
    Abstract: The present invention relates to the discovery of novel proteins of mammalian origin which are immediate downstream targets for FKBP/rapamycin complexes.
    Type: Application
    Filed: June 24, 2004
    Publication date: March 17, 2005
    Applicant: ARIAD Gene Therapeutics, Inc.
    Inventors: Vivian Berlin, Maria Chiu, Guillaume Cottarel, Veronique Damagnez