Abstract: A seal assembly is for sealing a space between first and second members and includes a generally annular elastomeric seal body disposed about an outer surface of the first member and extending circumferentially about a central axis. The body includes a base portion and a sealing portion, the sealing portion having an inner end integrally formed with the base portion and an outer, free end sealingly engageable with an axial surface of the second member so as to define a generally annular seal interface. A wiper is coupled with the seal body and has an engagement portion contactable with an axial surface of the second member at a position spaced radially outwardly from the sealing portion outer end. As such, the wiper engagement portion directs substances on the second member axial surface generally away from the sealing interface when the wiper contacts the substances during rotation of the rotatable member.

Abstract: A seal assembly is for sealing a space between first and second members, the first member having a central axis and an outer circumferential surface extending about the axis, the second member having a radially-extending axial surface. The seal assembly includes a generally annular elastomeric seal body disposed about the first member outer surface and extending circumferentially about the central axis, the body including a base portion and a sealing portion having an inner end integrally formed with the base portion and an outer, free end sealingly engageable with the second member axial surface, a generally annular cavity being defined between the base portion and the sealing portion. A biasing member is disposed within the annular cavity and is configured to exert a generally radially-inwardly directed force on the seal body so as to substantially prevent relative angular displacement between the seal body and the first member.

Abstract: A method of forming a seal assembly for sealing a space between a first member having a central axis and an outer surface and a second member having a radially-extending axial surface includes the following steps: providing an elongated elastomeric body and a biasing member, the elongated body having opposing ends and a generally V-shaped groove generally along a length of the body between the two ends; bending the elongated body circumferentially about the first member outer surface; coupling the ends of the elongated body to form an annular seal body; and positioning the biasing member within the groove such that the biasing member exerts a radially-inwardly directed force on the annular seal body so as to substantially prevent relative angular displacement between the seal body and the first member.

Abstract: Compounds of general formula (I): where A, E, G, X, Y and the bond - - - take various meanings are of use in the preparation of a pharmaceutical formulation, for example in the treatment of a disease in which GSK-3 is involved, including Alzheimer's disease or the non-dependent insulin diabetes mellitus, or hyperproliferative disease such as cancer, displasias or metaplasias of tissue, psoriasis, arteriosclerosis or restenosis.

Abstract: Compounds of general formula (I): where A, E, G, X, Y and the bond - - - take various meanings are of use in the preparation of a pharmaceutical formulation, for example in the treatment of a disease in which GSK-3 is involved, including Alzheimer's disease or the non-dependent insulin diabetes mellitus, or hyperproliferative disease such as cancer, displasias or metaplasias of tissue, psoriasis, arteriosclerosis or restenosis.

Abstract: Compounds of general formula (I): where A, E, G, X, Y and the bond - - - take various meanings are of use in the preparation of a pharmaceutical formulation, for example in the treatment of a disease in which GSK-3 is involved, including Alzheimer's disease or the non-dependent insulin diabetes mellitus, or hyperproliferative disease such as cancer, displasias or metaplasias of tissue, psoriasis, arteriosclerosis or restenosis.

Abstract: Compounds of general formula (I): 1