Abstract: It is claimed the invention of a composition and a device to be used in medical therapy as a containment matrix in conformational intra-tissue beta brachytherapy. The composition is made so as to form a gel which can be injected intra-tissue without toxicity in the organism, holding in suspension during injection the particulate of a beta-emitting brachytherapy composition, and forming after injection a solid deposit that immobilizes the radiotherapeutic composition in the injection bolus, to prevent migration of the radioactive product into the surrounding tissues. The composition is injected with an apparatus dedicated to percutaneous intra-tissue injection comprising a 7-degree robotic apparatus, an automatic injection device under pressure, a needles system to provide the therapeutic composition application in the tissue to be treated with minimal trauma.

Abstract: Disclosed is a layer structure for epidermal radionuclide therapy (brachytherapy) of a patient comprising, from a patient's view, a proximal adherent layer for applying the layer structure on the skin surface to be treated of a patient; a flexible, transparent carrier layer that from a patient's view is located in a distal direction on the adherent layer; and at least one radionuclide-containing emission layer located on the carrier layer, the adherent layer and the carrier layer with regard to their components and thickness being formed such that they are essentially transparent for ? and ? radiation. The layer structure is suited particularly for radiotherapeutic treatment of the basal-cell carcinoma (BCC) and the squamous cell carcinoma (SCC). With the aid of the layer structure, geometrically complex skin lesions caused by a tumor, as occurring e.g. on the outer edge of the auricle, may be treated easily.

Abstract: Embodiments of the invention relate to a method of treating a cancerous or non-cancerous skin lesion of a subject, e.g. a human patient, by epidermal radioisotope therapy, a specialized type of brachytherapy. The method can include defining and marking an area of skin to be treated; covering the area with a protective layer, e.g. a protective film or foil; applying a tailor-made radioactive source by applying a layer of a radioactive source material on the protective layer, such that the area is covered by the material while any area not to be treated is spared; and removing the radioactive source after a predetermined time period of irradiation.

Abstract: An applicator for applying a radioactive substance to a biological tissue, the applicator comprising a container for receiving the radioactive substance; an application device connectable to the container, by which the substance compound can be applied to the tissue; and at least a part of a conveying device by which the radioactive substance can be supplied from the container into the application device when the application device has been connected to the container.

Abstract: Disclosed is a layer structure for epidermal radionuclide therapy (brachytherapy) of a patient comprising, from a patient's view, a proximal adherent layer for applying the layer structure on the skin surface to be treated of a patient; a flexible, transparent carrier layer that from a patient's view is located in a distal direction on the adherent layer; and at least one radionuclide-containing emission layer located on the carrier layer, the adherent layer and the carrier layer with regard to their components and thickness being formed such that they are essentially transparent for ? and ? radiation. The layer structure is suited particularly for radiotherapeutic treatment of the basal-cell carcinoma (BCC) and the squamous cell carcinoma (SCC). With the aid of the layer structure, geometrically complex skin lesions caused by a tumor, as occurring e.g. on the outer edge of the auricle, may be treated easily.

Abstract: An applicator for applying a radioactive substance to a biological tissue, the applicator comprising a container for receiving the radioactive substance; an application device connectable to the container, by which the substance compound can be applied to the tissue; and at least a part of a conveying device by which the radioactive substance can be supplied from the container into the application device when the application device has been connected to the container.

Abstract: The present invention refers to a method of treating a cancerous or non-cancerous skin lesion of a subject, e.g. a human patient, by epidermal radioisotope therapy, a specialized type of brachytherapy, comprising the steps of (a) defining and marking an area of skin to be treated; (b) covering said area with a protective layer, e.g. a protective film or foil; (c) applying a tailor-made radioactive source by applying a layer of a radioactive source material on said protective layer, such that said area is covered by said material while any area not to be treated is spared; and (d) removing the radioactive source after a predetermined time period of irradiation.