Patents by Inventor Maria Donnarumma

Maria Donnarumma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for preparing sertraline hydrochloride polymorphs
    Patent number: 7189876
    Abstract: This invention relates to crystalline polymorphs of sertraline hydrocloride, i.e. (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphtalenamine hydrochloride, denominated form I, II and V, and methods for their preparation.
    Type: Grant
    Filed: July 14, 2004
    Date of Patent: March 13, 2007
    Assignee: Recordati Industria Chimica e Farmaceutica S.p.A.
    Inventors: Fausto Bonifacio, Cristina Crescenzi, Maria Donnarumma, Dimitri Ippoliti
  • Sertraline hydrochloride form II and methods for the preparation thereof
    Patent number: 7173153
    Abstract: This invention relates to a method for the preparation of sertraline hydrochloride, (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphtalenamine hydrochloride, in its crystalline form II.
    Type: Grant
    Filed: July 14, 2004
    Date of Patent: February 6, 2007
    Assignee: Recordati Industria Chimica E. Farmaceutica S.p.A.
    Inventors: Fausto Bonifacio, Cristina Crescenzi, Maria Donnarumma, Dimitri Ippoliti
  • Sertraline hydrochloride form II and methods for the preparation thereof
    Publication number: 20050032906
    Abstract: This invention relates to a method for the preparation of sertraline hydrochloride, (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphtalenamine hydrochloride, in its crystalline form II.
    Type: Application
    Filed: July 14, 2004
    Publication date: February 10, 2005
    Inventors: Fausto Bonifacio, Cristina Crescenzi, Maria Donnarumma, Dimitri Ippoliti
  • Methods for preparing sertraline hydrochloride polymorphs
    Publication number: 20050032907
    Abstract: This invention relates to crystalline polymorphs of sertraline hydrocloride, i.e. (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphtalenamine hydrochloride, denominated form I, II and V, and methods for their preparation.
    Type: Application
    Filed: July 14, 2004
    Publication date: February 10, 2005
    Inventors: Fausto Bonifacio, Cristina Crescenzi, Maria Donnarumma, Dimitri Ippoliti
  • Process for the production of paroxetine
    Patent number: 6583287
    Abstract: A process for the production of paroxetine is described, wherein N-substituted derivatives of 4-(p-fluorophenyl)-3-hydroxymethyl-1,2,3,6-tetrahydropyridine are treated according to the following sequence of reactions: (a) hydrogenation catalyzed by transition metal complexes with chiral diphosphinic ligands; (b) —OH derivatisation and nucleophilic substitution, the substituent being sesamol; (c) N-dealkylation. The process is highly stereospecific and brings about the formation of intermediates enriched with the desired isomeric components, which are converted into paroxetine in quantitative yields.
    Type: Grant
    Filed: July 30, 2001
    Date of Patent: June 24, 2003
    Assignee: Recordati S.A. Chemical and Pharmaceutical Company
    Inventors: Renzo Rossi, Stefano Turchetta, Maria Donnarumma