Patents by Inventor Maria DUPONT

Maria DUPONT has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10143722
    Abstract: The present invention relates to the field of genetic engineering and medicine. Proposed is a method for treating neurodegenerative diseases and Alzheimer's disease that includes the intranasal administration to a subject of a therapeutically effective amount of the YB-1 protein and/or active fragment and/or derivative thereof.
    Type: Grant
    Filed: August 21, 2014
    Date of Patent: December 4, 2018
    Inventor: Maria Dupont
  • Publication number: 20160076066
    Abstract: Process for production of (R)-3-Quinuclidinol by reduction of Quinuclidin-3-one with cofactor and oxidoreductase, characterized in that, the oxidoreductase comprises an amino acid sequence motif MQX1REX2X3WEA, wherein each of X1, X2, X3 are any of amino acid residues A (Ala), R (Arg), N (Asn), D (Asp), C (Cys), Q (Gln), E (Glu), G (Gly), H (His), I (Ile), L (Leu), K (Lys), M (Met), F (Phe), P (Pro), S (Ser), T (Thr), W (Trp), Y (Tyr) or V (Val).
    Type: Application
    Filed: April 28, 2014
    Publication date: March 17, 2016
    Inventors: Antje GUPTA, Maria DUPONT, Anke TSCHENTSCHER
  • Patent number: 9228214
    Abstract: In a process for the enantioselective enzymatic reduction of a hydroxy ketone of general formula I wherein R1?C1-C6 alkyl and R2?—Cl, —CN, —OH, —H or C1-C6 alkyl, into a chiral diol of general formula II wherein R1 and R2 have the same meaning as in formula I, the hydroxy ketone is reduced with an oxidoreductase in the presence of NADH or NADPH as a cofactor, wherein a) the hydroxy ketone is provided in the reaction at a concentration of ?50 g/l, b) the oxidized cofactor NAD or NADP having formed is regenerated continuously by oxidation of a secondary alcohol of general formula RXRYCHOH, wherein RX, RY independently represent hydrogen, branched or unbranched C1-C8-alkyl and Ctotal?3, and c) the reduction of the hydroxy ketone and the oxidation of the secondary alcohol are catalyzed by the same oxidoreductase.
    Type: Grant
    Filed: February 4, 2015
    Date of Patent: January 5, 2016
    Assignee: CAMBREX IEP GMBH
    Inventors: Antje Gupta, Maria Dupont, Anke Tschentscher
  • Publication number: 20150152451
    Abstract: In a process for the enantioselective enzymatic reduction of a hydroxy ketone of general formula I wherein R1=C1-C6 alkyl and R2?—Cl, —CN, —OH, —H or C1-C6 alkyl, into a chiral diol of general formula II wherein R1 and R2 have the same meaning as in formula I, the hydroxy ketone is reduced with an oxidoreductase in the presence of NADH or NADPH as a cofactor, wherein a) the hydroxy ketone is provided in the reaction at a concentration of ?50 g/l, b) the oxidized cofactor NAD or NADP having formed is regenerated continuously by oxidation of a secondary alcohol of general formula RXRYCHOH, wherein RX, RY independently represent hydrogen, branched or unbranched C1-C8-alkyl and Ctotal?3, and c) the reduction of the hydroxy ketone and the oxidation of the secondary alcohol are catalyzed by the same oxidoreductase.
    Type: Application
    Filed: February 4, 2015
    Publication date: June 4, 2015
    Applicant: CAMBREX IEP GMBH
    Inventors: Antje GUPTA, Maria DUPONT, Anke TSCHENTSCHER