Abstract: An Adhesive composition for us in surgery, especially ophthalmic surgery, comprises a mixture of a cyanoacrylate of general formula (I) and an acrylate compound of formula (II) where R4 is an alkylene group and Y is a cycloalkyl group or Y═OR where R═H or acryloyl. It is found that compositions of this type have a number of advantages over simple cyanoacrylate adhesives, including: (a) a longer cure time, allowing easier handling of the joint; (b) a more flexible cured product; (c) a tendency for the cured to come away from the tissue after a month or so thus facilitating healing; and (d) a substantially non-exothermic curing reaction, thereby avoiding thermal damage to the tissue.