Patents by Inventor Maria Elena Bottazzi

Maria Elena Bottazzi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • A NOVEL SARS IMMUNOGENIC COMPOSITION
    Publication number: 20160376321
    Abstract: Embodiments of the disclosure concern immunogenic compositions and methods for treating or preventing Severe acute respiratory syndrome (SARS). The compositions and methods concern a portion of the receptor-binding domain (RBD) of the SARS-CoV spike protein. In at least particular cases, a mutated version of a portion of the RBD is utilized, such as a deglycosylated mutant of the RBD.
    Type: Application
    Filed: November 21, 2014
    Publication date: December 29, 2016
    Applicant: BAYLOR COLLEGE OF MEDICINE
    Inventors: Peter Jay Hotez, Maria Elena Bottazzi, Bin Zhan, Wen-Hsiang Chen, Shivali Chag
  • Multivalent antihelminthic vaccine
    Patent number: 8444994
    Abstract: A multivalent anthelmintic vaccine targets both hookworm and schistosomiasis. The vaccine includes, at a minimum, a recombinant third-stage larval hookworm antigen, a recombinant adult stage hookworm antigen, and a recombinant schistosome antigen. Preferably, the hookworm antigens are Necator americanus antigens, although antigens from other hookworm species (e.g. Ancylostoma duodenale) may also be employed. The schistosome antigen is preferably a Schistosoma mansoni or a Schistosoma haematobium antigen although antigens from other schistosome species (e.g. Schistosoma japonicum) may also be employed. In some cases full or partial sequences of schistosome antigens may be fused with full or partial sequences of hookworm {Necator americanus) to produce recombinant chimeric antigens.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: May 21, 2013
    Assignees: The Albert B. Sabin Vaccine Institute, The George Washington University, The Council of the Queensland Institute of Medical Research
    Inventors: Peter Hotez, Alexander Loukas, Mark Pearson, Jeffrey Bethony, Bin Zhan, Gaddam Goud, Maria Elena Bottazzi, David Diemert, Ami Shah Brown, Peter Giacomautonio
  • Human hookworm vaccine
    Patent number: 8211438
    Abstract: A vaccine for human hookworm is provided. The vaccine comprises at least one L3 larval stage antigen (e.g. Na-ASP-2 or Na-SAA-2) and at least one adult stage human hookworm antigen (e.g. Na-APR-1, Na-CP-2, Na-CP-3, Na-CP-4, Na-CP-5, or Na-GST-1) and adjuvants.
    Type: Grant
    Filed: June 26, 2009
    Date of Patent: July 3, 2012
    Assignee: The George Washington University
    Inventors: Peter Hotez, Alexander Loukas, Bin Zhan, Gaddam Goud, Jeffrey Bethony, Maria Elena Bottazzi, Aaron Miles
  • MULTIVALENT ANTIHELMINTHIC VACCINE
    Publication number: 20110200640
    Abstract: A multivalent anthelmintic vaccine targets both hookworm and schistosomiasis. The vaccine includes, at a minimum, a recombinant third-stage larval hookworm antigen, a recombinant adult stage hookworm antigen, and a recombinant schistosome antigen. Preferably, the hookworm antigens are Necator americanus antigens, although antigens from other hookworm species (e.g. Ancylostoma duodenale) may also be employed. The schistosome antigen is preferably a Schistosoma mansoni or a Schistosoma haematobium antigen although antigens from other schistosome species (e.g. Schistosoma japonicum) may also be employed. In some cases full or partial sequences of schistosome antigens may be fused with full or partial sequences of hookworm {Necator americanus) to produce recombinant chimeric antigens.
    Type: Application
    Filed: June 30, 2009
    Publication date: August 18, 2011
    Inventors: Peter Hotez, Alexander Loukas, Mark Pearson, Jeffrey Bethony, Bin Zhan, Gaddam Goud, Maria Elena Bottazzi, David Diemert, Ami Shah Brown, Peter Giacomantonio
  • Human Hookworm Vaccine
    Publication number: 20100003285
    Abstract: A vaccine for human hookworm is provided. The vaccine comprises at least one L3 larval stage antigen (e.g. Na-ASP-2 or Na-SAA-2) and at least one adult stage human hookworm antigen (e.g. Na-APR-1, Na-CP-2, Na-CP-3, Na-CP-4, Na-CP-5, or Na-GST-1) and adjuvants.
    Type: Application
    Filed: June 26, 2009
    Publication date: January 7, 2010
    Inventors: Peter Hotez, Alexander Loukas, Bin Zhan, Gaddam Goud, Jeffrey Bethony, Maria Elena Bottazzi, Aaron Miles
  • Human Hookworm Vaccine
    Publication number: 20080166377
    Abstract: A vaccine for human hookworm is provided. The vaccine comprises at least one L3 larval stage antigen (e.g. Na-ASP-2 or Na-SAA-2) and at least one adult stage human hookworm antigen (e.g. Na-APR-1, Na-CP-2, Na-CP-3, Na-CP-4, Na-CP-5, or Na-GST-1) and adjuvants.
    Type: Application
    Filed: September 28, 2007
    Publication date: July 10, 2008
    Inventors: Peter Hotez, Alexander Loukas, Bin Zhan, Gaddam Goud, Jeffrey Bethony, Maria Elena Bottazzi, Aaron Miles
  • Hookworm vaccine
    Patent number: 7303752
    Abstract: Preparations which elicit an immune response to hookworm antigens and which may be utilized as hookworm vaccines are provided. In addition, a method of increasing the effectiveness of vaccinations against infectious diseases in patients infected with hookworm is provided. The method involves chemically treating the hookworm infestation prior to administering the vaccine.
    Type: Grant
    Filed: April 16, 2004
    Date of Patent: December 4, 2007
    Assignee: The George Washington University
    Inventors: Peter Hotez, James Ashcom, Mahnaz Bdamchian, Bin Zhan, Yan Wang, John Hawdon, Alexander Loukas, Angela Williamson, Brian Jones, Jeffrey Bethony, Gaddam Goud, Maria Elena Bottazzi, Susana Mendez