Patents by Inventor Maria Elisa Piccone

Maria Elisa Piccone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080176962
    Abstract: Methods and compositions for rapidly identifying CGEPs required for viral infection of mammalian cells are provided. Also provided are methods of inhibiting viral infection of mammalian cells by inhibiting the activity of one or more CGEPs (e.g., as identified in accordance with methods of the invention) in the cells. Aspects of the invention further include specifically identified CGEPs implicated in mammalian cell infection of specific viruses, e.g., African Swine Fever Virus and Foot and Mouth Virus, and methods of modulating their activity to achieve viral resistance.
    Type: Application
    Filed: August 2, 2007
    Publication date: July 24, 2008
    Inventors: Stanley N. Cohen, Daniel Rock, Annie Chang, Yanan Feng, Laszlo Zsak, Maria Elisa Piccone
  • Patent number: 5824316
    Abstract: A foot-and-mouth disease virus has been genetically engineered by deleting the nucleic acid sequence encoding the leader (L) proteinase from an infectious cDNA copy of the viral genome and producing an L proteinase-deleted virus. The L proteinase-deleted viruses are able to assemble and grow in cells in culture, but, since they lack L proteinase, they are less toxic to infected cells within the animal, producing an attenuated infection. The recombinant virus can be formulated into an effective vaccine for the prevention of foot-and-mouth disease.
    Type: Grant
    Filed: May 24, 1996
    Date of Patent: October 20, 1998
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Marvin J. Grubman, Peter W. Mason, Maria Elisa Piccone, Elizabeth Rieder