Patents by Inventor Maria Elizabeth Zwaagstra

Maria Elizabeth Zwaagstra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6136848
    Abstract: This invention relates to a flavone derivative represented by the formula (1) or a salt thereof, and also to a medicine containing the same. ##STR1## wherein A represents H, halogen, phenyl, naphthyl, a group of the formula (2) in which X is H or halogen, B is --CH.dbd.CH--, --CH.dbd.N--, --N(R.sup.7)-- (R.sup.7 : lower alkyl or alkoxyalkyl), --O-- or --S--; W represents a single bond, --CH.sub.2 O-- or --CH.dbd.CH--; at least one of R.sup.1 to R.sup.4 represents --COOH, --CN, alkyloxycarbonyl, tetrazolyl or --CONHR.sup.8 (R.sup.8 : H, lower alkyl or phenylsulfonyl), the remainder thereof individually represent H, halogen, --OH, lower alkyl or lower alkoxyl; R.sup.5 represents H, --OH, lower alkoxyl, --O(CH.sub.2).sub.m NR.sup.9 R.sup.10 (R.sup.9,R.sup.10 : H or lower alkyl, or coupled together with the adjacent N to form a phthalimido group; m: 1-5), or a group of the formula (3) (n: 1-5, l: 2-3; and R.sup.6 represents H, halogen, lower alkyl or lower alkoxyl.
    Type: Grant
    Filed: October 2, 1997
    Date of Patent: October 24, 2000
    Assignee: Kowa Co., Ltd.
    Inventors: Maria Elizabeth Zwaagstra, Mingqiang Zhang, Henk Timmerman, Masahiro Tamura, Yasushi Wada
  • Patent number: 6046212
    Abstract: This invention relates to chalcone derivatives represented by the following formula (1): wherein A represents a phenyl group, a quinolyl group or the like, W represents a vinylene group or the like, and R.sup.1 to R.sup.5 each independently represent a carboxyl, cyano, alkyloxycarbonyl or like group, or salts of the chalcone derivatives, and also to drugs containing them as effective ingredients. These compounds have excellent cys-LT receptor antagonism, and are useful as antiallergic agents or the like.
    Type: Grant
    Filed: November 17, 1998
    Date of Patent: April 4, 2000
    Assignee: Kowa Co., Ltd.
    Inventors: Maria Elizabeth Zwaagstra, Mingqiang Zhang, Henk Timmerman, Kazuhiro Onogi, Masahiro Tamura, Tsutomu Toma, Yasushi Wada