Abstract: Disclosed herein is a medical instrument (100, 300) comprising an activity measurement system (110, 301, 302) configured for measuring brain activity data (136) from a subject (102), a memory (120) storing machine executable instructions (130) and storing a simulation model (132), wherein the simulation model is configured to generating simulation data (134), wherein the simulation model is configured for modifying the simulation data using a model parameter (140), a virtual reality system (106, 106?, 106?, 106??, 106??) configured for rendering the simulation data; and a computational system (114) for controlling the medical instrument. Execution of the machine executable instructions causes the computational system to set (200) the model parameter to an initial value (142).

Abstract: The present invention relates to attention bias modification treatment. In order to improve the treatment effect, an ABM system is proposed with a neural brain response monitoring device, such as functional magnetic resonance imaging (fMRI), magnetoencephalography (MEG), and/or electroencephalography (EEG), to provide real-time information regarding neural brain responses in order to personalize and optimize the ABM treatment.

Abstract: A system and method for analyzing the brain activity of a subject during a transition between brain states. Brain activity data including data representative of a transition between brain states is received from a brain monitoring system and processed to obtain a value for one or more transition parameters. The one or more transition parameters are parameters that characterize the transition between brain states and may be used as a biomarker for identifying mental disorders.

Abstract: The present invention relates to an apparatus (10) for determining and/or assessing depression severity of a patient. The apparatus comprising: an input unit (20); an image display unit (30); at least one sensor (40); and a processing unit (50). The image display unit is configured to present a plurality of images to a patient and the plurality of images are of different human facial expressions. The at least one sensor is configured to acquire information relating to the patients viewing of the plurality of images. The input unit is configured to provide the processing unit with the information relating to the patients viewing of the plurality of images. The input unit is configured to provide the processing unit with MRI scan image data of the patient. The MRI scan image data of the patient comprises MRI scan image data of at least one part of the patients brain associated with recognition of facial expressions and/or associated with affective disorders.

Abstract: A system comprises a first sensor for generating a swelling signal based on the user pressing on the first sensor with a body part, a second sensor for generating a blood signal which is indicative of the volume of blood in the body part when the user presses on the first sensor and a force sensor for measuring the force applied by the body part to the first sensor when the user presses on the first sensor. The system also comprises a processor configured to determine an indication of swelling for the body part based on the swelling signal when the force sensor measures a first pre-determined value, determine an indication of blood pressure at the body part based on a force value measured by the force sensor when the blood signal reaches a second pre-determined value.

Abstract: It is proposed to obtain information about a stress or anxiety level of a subject within a predetermined time period before, during and/or after a capture time of a fMRI scan image. Using this information, embodiments may provide additional/supplementary information that may aid, assist or otherwise improve interpretation of the fMRI scan image.

Abstract: A system for unobtrusively determining a fertile window includes a contact sensor in contact with the woman and configured to provide a signal indicative of respiration of the woman. A processor is configured to process the signal to obtain a biomechanical parameter indicative of the respiration, and determine the fertile window of the woman based on a change in the obtained biomechanical parameter.

Abstract: Two subsequent fMRI images taken during or around an EMDR therapy treatment are compared. A change in a trauma level metric in relevant brain anatomy of a traumatized patient is determined and communicated, such that the success of the EMDR therapy can be more objectively assessed and/or the information may be used to tailor the EMDR therapy a during or after a therapy session.

Abstract: The present invention relates to sleepiness assessment. In order to provide a more accurate measure to predict OSA severity, an apparatus is provided for sleepiness assessment. The apparatus comprises an input unit, a processing unit, and an output unit. The input unit is configured to receive data indicative of an activity currently performed by a user. The processing unit is configured to determine, based on the activity currently performed by the user, a current situation the user is engaging in. The processing unit is configured to determine whether the current situation matches one of a plurality of pre-determined situations used for situational sleepiness assessment. In response to the determination that the current situation matches one of the plurality of predetermined situations, the processing unit is configured to send a notification to the user for a self-report of a user's current subjective sleepiness level and/or obtain a user's current objective sleepiness level from sensor data.

Abstract: The present invention relates to an agenda generation system (10), comprising: at least one first sensor unit (20); an input unit (30); a processing unit (40); and at least one output unit (50); wherein the at least one first sensor unit is configured to acquire physiological data of a subject over an extended period of time prior to a current time point and provide the physiological data to the processing unit, wherein the physiological data is assigned to different times during the extended period of time, and wherein the physiological data comprises one or more of: heart rate, ventricular high rate, blood pressure, respiration rate, skin conductance, step count; wherein the at least one first sensor unit is configured to acquire sleep data of the subject over the extended period of time and provide the sleep data to the processing unit, wherein the sleep data is assigned to different times during the extended period of time, and wherein the sleep data comprises one or more of: duration of sleep; total d

Abstract: The present invention relates to a device (100), system (500) and method for determining SpO2 (160) of a subject. Two types of PPG measurements, widefield PPG with a homogenous illumination and/or a spot pattern and radial PPG with a spot illumination, are used to quantify the discrepancy in penetration depths for electromagnetic radiation in the red spectral range and infrared spectral range. This discrepancy in penetration depth is then used to find a more stable ratio signals of ratios, RR, and thus a more accurate SpO2 (160).

Abstract: There is provided a controller for a fluid-detection system, wherein the controller is configured to: determine if a user is interacting with the fluid detection system, wherein the determining comprises at least one of: determining whether a user is within a predetermined distance of the fluid detection system; determining whether a user is in physical contact with the fluid detection system; determining whether a fluid sensor of the fluid detection system is in a mouth of a user; and control the temperature of the fluid sensor of the fluid detection system based on the result of the determination.

Abstract: A device is provided for controlling the nitric oxide levels within the lungs of a subject. The device comprises a detector for detecting the respiration cycle of the subject and a stimulator for applying an acoustic or vibratory stimulus to the subject. The stimulator is controlled in dependence on the detected respiration cycle. In particular, acoustic stimulation may be provided at the onset of inspiration. In this way, the nitric oxide flow can be controlled in a way to ensure that the paranasal nitric oxide is nearly fully inspired. This provides a higher nitric oxide concentration in the lung/alveoli.

Abstract: A computer-implemented method (100) of producing a sleep evaluation for a user for use with a sleep therapy is disclosed. The method comprises, with a processor arrangement (12), receiving (122) a perceived value of a sleep parameter from the user, said sleep parameter corresponding to sleep behavior of said user at a point in time during said sleep therapy; receiving (124) sleep monitoring data from an electronic sleep monitor, said sleep monitoring data incorporating an objective value of said sleep parameter at said point in time; and, in case of the perceived value being different to the objective value, processing the sleep monitoring data such as to augment (132) said objective value into a further value of said sleep parameter to reduce the discrepancy between the perceived value and the objective value; and producing (134) a sleep evaluation output for the user comprising at least the further value of said sleep parameter.

Abstract: A system for guiding sleep restriction therapy is based on sleep data as well as medication data for a subject for a plurality of nightly sleep sessions. The sleep data and the medication data are processed to derive a target in-bed duration and to derive a target medication dose. A sleep restriction and medication recommendation are then output based on the target in-bed duration and the target medication dose. This system implements an improved sleep restriction therapy method that not only promotes the usual gradual increase of the allowed sleeping window, but also enables implementation of a gradual decrease of sleeping medication, which is beneficial for therapy adherence.

Abstract: The present invention relates to circadian rhythm management. In order to improve circadian rhythm management, an apparatus is provided that uses an alternative exercise-based concept and personalized approach for managing or controlling personal circadian rhythm and optimizing sleep onset.

Abstract: The present invention relates to a device (10, 10a, 10b), system (1, 2, 3) and method for detection of an asthma attack or asthma of a subject. For this purpose, the device comprises a light sensor input (11), e.g. a 2D camera, for obtaining light sensor data of the scene and a thermal sensor input (12), e.g. a thermal camera, for obtaining thermal sensor data of a scene including a subject while breathing. An analysis unit (13) obtains these data and derives respiratory effort information indicating respiratory efforts of the subject from the obtained light sensor data and/or the obtained thermal sensor data and derives airflow information indicating airflow during respiration of the subject from the obtained thermal sensor data. Further, the analysis unit (13) predicts or detects an asthma attack or asthma based on analysis of the respiratory effort information and the airflow information, said analysis evaluating deviations from predetermined or healthy correlations between respiratory efforts and airflow.

Abstract: The invention relates to a system, method and corresponding computer program for unobtrusively determining a fertile window. In particular, it relates to a wearable system such as integrated in a bra for supporting personalized prediction of the fertile window for a planned parent-hood purpose. The system (1) comprises a contact sensor unit (10) for providing a signal in contact with the woman, wherein the signal is indicative of respiration of the woman, and a processing unit (20) for processing the signal to obtain a biomechanical parameter indicative of respiration, wherein the processing unit (20) is configured to determine the fertile window of the woman based on a change in the obtained biomechanical parameter. The system (1) allows a reliable unobtrusive determination of a fertile window of a women.

Abstract: A system (1) and corresponding method for determining an impact of an active substance on an infant comprises: a parameter providing unit (10) for providing age and weight of the infant, an intake estimation unit (20) for estimating the amount of intake of the active substance by a breastfeeding caregiver of the infant, a substance level determination unit (30) for determining a level of the active substance in breast milk at the time of breastfeeding based on a history of the estimated intake of the active substance, and an impact determination unit (40) for determining an impact of the active substance on the infant based on i) the determined level of the active substance in the breast milk at the time of breastfeeding, and ii) the age and weight of the infant. The system (1) allows a determination of the impact of an active substance on the infant.

Abstract: The present disclosure relates to a system (60) for monitoring a state of well-being of an individual, the system (60) comprising a remotely operating sensing unit (30) comprising at least one image sensor (32, 34) arranged to remotely monitor a skin portion of a user, a close-up sensing unit (56) provided at a hand-held personal care appliance (40), the close-up sensing unit (56) being arranged to monitor a physiological signal of the user, wherein the monitoring of the physiological signal is temporally aligned with the remote monitoring of the skin portion of the user, and a control unit (70) arranged to process first sensor data provided by the remotely operating sensing unit (30) and second sensor data provided by the close-up sensing unit (56), wherein the control unit (70) is arranged to process, based on the processed first sensor data and second sensor data, at least one well-being parameter, and wherein the control unit (70) is arranged to provide, based on the at least one processed parameter, well