Abstract: The invention is generally related to topical ophthalmic compositions comprising: from about 0.05 w/v % to about 5 w/v % of galactomannan polymer; a cis-diol and about 0.5 w/v % to about 10 w/v % of a hydrophilic copolymer which comprises (a) arylborono-containing repeating units each having a boronic acid, (b) repeating units of at least one phosphorylcholine-containing vinylic monomer, and (c) acrylic monomeric units of at least one acrylic monomer having 3 to 16 carbon atoms, the ophthalmic composition is substantially free of a borate for improving lubrication, hydration and drug delivery property.

Abstract: The present invention generally relates to silicone hydrogel contact lenses each inherently having, on lens surfaces, a relatively-high concentration of primary amino groups and to a method for producing the same. The invention is also related to silicone hydrogel contact lens precursors each inherently having, on lens surfaces, a relatively-high concentration of N-Boc-protected primary amino groups which can be easily and conveniently deprotected during lens extraction and/or hydration steps.

Abstract: The invention is generally related to a soft contact lens which comprises a hydrogel lens body and a coating of a hydrophilic copolymer thereon and to a method for producing the same. The hydrogel lens body comprises or is made of a polymeric material having 1,2- and/or 1,3-diol moieties, and the hydrophilic copolymer comprises arylborono-containing repeating units each having a boronic acid group. The coating is covalently-attached to the hydrogel lens body through cyclic boronic ester linkages each formed between one boronic acid group and one 1,2-diol or 1,3-diol group. The soft contact lens has a surface lubricity higher than the surface lubricity of the lens body.

Abstract: The invention is generally related to topical ophthalmic compositions comprising: from about 0.05 w/v % to about 5 w/v % of galactomannan polymer; a cis-diol and about 0.5 w/v % to about 10 w/v % of a hydrophilic copolymer which comprises (a) arylborono-containing repeating units each having a boronic acid, (b) repeating units of at least one phosphorylcholine-containing vinylic monomer, and (c) acrylic monomeric units of at least one acrylic monomer having 3 to 16 carbon atoms, the ophthalmic composition is substantially free of a borate for improving lubrication, hydration and drug delivery property.

Abstract: The present invention generally relates to silicone hydrogel contact lenses each inherently having, on lens surfaces, a relatively-high concentration of primary amino groups and to a method for producing the same. The invention is also related to silicone hydrogel contact lens precursors each inherently having, on lens surfaces, a relatively-high concentration of N-Boc-protected primary amino groups which can be easily and conveniently deprotected during lens extraction and/or hydration steps.

Abstract: The invention is generally related to a soft contact lens which comprises a hydrogel lens body and a coating of a hydrophilic copolymer thereon and to a method for producing the same. The hydrogel lens body comprises or is made of a polymeric material having 1,2- and/or 1,3-diol moieties, and the hydrophilic copolymer comprises arylborono-containing repeating units each having a boronic acid group. The coating is covalently-attached to the hydrogel lens body through cyclic boronic ester linkages each formed between one boronic acid group and one 1,2-diol or 1,3-diol group. The soft contact lens has a surface lubricity higher than the surface lubricity of the lens body.