Patents by Inventor Maria Flores

Maria Flores has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10870119
    Abstract: An apparatus is described. The apparatus comprises a liquid dispenser comprising a liquid outlet, the liquid dispenser being configured to generate a droplet stream. The apparatus also comprises a first fluid flow device configured to generate a confinement fluid flow for confining a trajectory of the droplet stream therein, the first fluid flow device comprising an outlet arranged to allow the droplet stream to exit therefrom, wherein the fluid outlet is arranged within the confinement fluid flow device. Furthermore, the apparatus comprises a second fluid flow device configured to generate a reaction fluid flow for reacting with droplets in the droplet stream, wherein the outlet of the first fluid flow device is arranged within the second fluid flow device. A method is also described.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: December 22, 2020
    Assignees: Ingeniatrics Tecnologías, Universidad de Sevilla
    Inventors: Miguel Angel Asensio Caño, Beatriz Talavera Almena, María Flores Mosquera, Alfonso Miguel Gañán-Calvo
  • Patent number: 10730029
    Abstract: Concentric flow focusing encapsulation devices and methods for production of microencapsulated droplets of a first core material surrounded by a second shell material include assessment of non-dimensional fluid dynamic parameters that are related to the characteristics of produced droplets. The parameters are specifically related to characteristics such as homogenous or non-homogenous modes of concentric droplet breakup, density distribution of various droplet sizes, and qualities such as monodispersity of droplets produced. By identifying control parameters in specific regions, control variables may be selected to produce droplets or particles with desired qualities.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: August 4, 2020
    Assignees: INGENIATRICS TECNOLOGIAS, S.L., UNIVERSIDAD DE SEVILLA
    Inventors: Alfonso Miguel Ganan-Calvo, Inmaculada Munoz, Jeronimo Escudero, Gloria Jurado, Antonio Serrano, Sandra Velazquez, Maria Flores Mosquera
  • Publication number: 20180272306
    Abstract: Concentric flow focusing encapsulation devices and methods for production of microencapsulated droplets of a first core material surrounded by a second shell material include assessment of non-dimensional fluid dynamic parameters that are related to the characteristics of produced droplets. The parameters are specifically related to characteristics such as homogenous or non-homogenous modes of concentric droplet breakup, density distribution of various droplet sizes, and qualities such as monodispersity of droplets produced. By identifying control parameters in specific regions, control variables may be selected to produce droplets or particles with desired qualities.
    Type: Application
    Filed: September 28, 2016
    Publication date: September 27, 2018
    Inventors: Alfonso Miguel GANAN-CALVO, Inmaculada MUNOZ, Jeronimo ESCUDERO, Gloria JURADO, Antonio SERRANO, Sandra VELAZQUEZ, Maria FLORES MOSQUERA
  • Publication number: 20180029055
    Abstract: An apparatus is described. The apparatus comprises a liquid dispenser comprising a liquid outlet, the liquid dispenser being configured to generate a droplet stream. The apparatus also comprises a first fluid flow device configured to generate a confinement fluid flow for confining a trajectory of the droplet stream therein, the first fluid flow device comprising an outlet arranged to allow the droplet stream to exit therefrom, wherein the fluid outlet is arranged within the confinement fluid flow device. Furthermore, the apparatus comprises a second fluid flow device configured to generate a reaction fluid flow for reacting with droplets in the droplet stream, wherein the outlet of the first fluid flow device is arranged within the second fluid flow device. A method is also described.
    Type: Application
    Filed: February 22, 2016
    Publication date: February 1, 2018
    Inventors: Miguel Angel ASENSIO CAÑO, Beatriz TALAVERA ALMENA, María FLORES MOSQUERA, Alfonso Miguel GAÑÁN-CALVO
  • Patent number: 9382659
    Abstract: An aqueous printing ink and coating composition contains colorant, one or more high molecular weight starches and one or more water soluble acrylic polymers or co-polymers.
    Type: Grant
    Filed: December 2, 2005
    Date of Patent: July 5, 2016
    Assignee: Sun Chemical Corporation
    Inventors: Sabino Apostol, Robert Catena, Alexander Chudolij, Ana Maria A. Flores, Mathew C. Mathew, Leda Mora, Jeannette Simoni-Truncellito
  • Patent number: 8076337
    Abstract: Derivatives of Et-743 or Et-770 or Et-729 are provided. The derivatives are of the general formula Ia.: wherein the substituent groups take various permitted meanings.
    Type: Grant
    Filed: April 6, 2010
    Date of Patent: December 13, 2011
    Assignee: Pharma Mar, S.A.
    Inventors: Valentin Martinez, Maria Flores, Pilar Gallego, Carmen Cuevas, Simon Munt, Ignacio Manzanares
  • Patent number: 7919493
    Abstract: This invention relates to antitumoral ecteinascidin derivatives that contain a fused ecteinascidin five ring system with a 1,4-bridge having the structure of formula (VIa) or (VIb) as described herein and compounds in which the —NH2 or —OH of the 1,4-bridge is derivatized, and related pharmaceutical compositions and methods. Such ecteinascidin derivatives include, but are not limited to, those compounds having formula (XVIIb): in which R1 and R4 together form a group of formula (VIa) or (VIb) as described herein, and R5, R7, R8, R14a, R14b, R15, and R21 are as defined herein.
    Type: Grant
    Filed: April 10, 2007
    Date of Patent: April 5, 2011
    Assignee: Pharma Mar, S.A.
    Inventors: Maria Flores, Andres Francesh, Pilar Gallego, Jose Luis Chicharro, Maria Zarzuelo, Carolina Fernandez, Ignacio Manzanares
  • Publication number: 20100197695
    Abstract: Derivatives of Et-743 or Et-770 or Et-729 are provided. The derivatives are of the general formula Ia.: wherein the substituent groups take various permitted meanings.
    Type: Application
    Filed: April 6, 2010
    Publication date: August 5, 2010
    Inventors: Valentin Martinez, Maria Flores, Pilar Gallego, Carmen Cuevas, Simon Munt, Ignacio Manzanares
  • Patent number: 7759345
    Abstract: Derivatives of Et-743 or Et-770 or Et-729 are provided. The derivatives are of the general formula (Ia) wherein the substituent groups take various permitted meanings.
    Type: Grant
    Filed: July 17, 2002
    Date of Patent: July 20, 2010
    Assignee: Pharma Mar, S.A.
    Inventors: Valentin Martinez, Maria Flores, Pilar Gallego, Carmen Cuevas, Simon Munt, Ignacio Manzanares
  • Publication number: 20090215154
    Abstract: The invention relates to a method of obtaining micro- and nanometric polymeric particles in a controlled, reproducible manner. The aforementioned particles have a spherical shape and a very narrow, uniform size distribution. The invention comprises the use of an easy particle-forming method consisting in using hydrodynamic forces to focus a composite microjet formed by two concentric fluids and can be used in the encapsulation of fragile compounds of biological interest, from peptides and proteins to cells and micro-organisms.
    Type: Application
    Filed: May 3, 2006
    Publication date: August 27, 2009
    Inventors: Miguel Alfonso Ganan Calvo, Sebastien Chavez De Diego, Angel Cebolla Ramirez, Maria Flores Mosquera, Elena De Castro Hernandez
  • Publication number: 20090214655
    Abstract: The invention relates to a method and device for obtaining micro and nanometric particles in a controlled, reproducible manner. The aforementioned particles have a spherical shape and a very narrow, uniform size distribution. More specifically, the invention relates to a novel method of forming emulsions and to the application thereof in micro and nanoencapsulation techniques involving the extraction/evaporation of the solvent. In particular, the invention relates to the encapsulation of the fluorescent compounds and the subsequent application thereof.
    Type: Application
    Filed: January 26, 2006
    Publication date: August 27, 2009
    Inventors: Alfonso Miguel Ganan Calvo, Lucia Martin Banderas, Maria Flores Mosquera, Alfonso Rodriguez Gil, Sebastian Chavez De Diego, Angel Cebolla Ramirez
  • Publication number: 20080146580
    Abstract: This invention relates to antitumoral ecteinascidin derivatives.
    Type: Application
    Filed: April 10, 2007
    Publication date: June 19, 2008
    Applicant: PHARMAMAR
    Inventors: Maria Flores, Andres Francesh, Pilar Gallego, Jose Luis Chicharro, Maria Zarzuelo, Carolina Fernandez, Ignacio Manzanares
  • Publication number: 20070289486
    Abstract: An aqueous printing ink and coating composition contains colorant, one or more high molecular weight starches and one or more water soluble acrylic polymers or co-polymers.
    Type: Application
    Filed: December 2, 2005
    Publication date: December 20, 2007
    Applicant: SUN CHEMICAL CORPORATION
    Inventors: Sabino Apostol, Robert Catena, Jeannette Simoni-Truncellito, Alexander Chudolij, Ana Maria Flores, Mathew Mathew, Leda Mora
  • Patent number: 7202361
    Abstract: This invention relates to compounds of the formula: wherein: the substituent groups defined by R1, R2 are each independently selected of H, C(?O)R?, C1–C18 alkyl, C2–C18 alkenyl, C2–C18 alkynyl, or aryl; each of the R? groups is independently selected from the group consisting of H; OH; NO2; NH2; SH; CN; halogen; ?O; C(?O)H; C(?O)CH3; CO2H; or C1–C18 alkyl, C2–C18 alkenyl, C2–C18 alkynyl, or aryl, each of which, independently, may be substituted with one or more substituents selected from the group consisting of halogen, cyano, hydroxy, nitro, azido; alkanoyl, carboxamido, alkyl, alkenyl, alkynyl, aryloxy, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, aminoalkyl, carbocylic aryl having 6 or more carbons, and aralkyl; X2 is OX1 or N(X1)2 wherein each X1 is independently H, C(?O)R? where R? is as defined, C1–C18 alkyl, C2–C18 alkenyl, C2–C18 alkynyl, aryl, alkoxy, heterocyclyl, or two X1 groups together form a cyclic substituent on the nitrogen atom, or X1 is SO2CH3 when X2 is OX1, or N(X1)2 is NHCOalk
    Type: Grant
    Filed: April 12, 2001
    Date of Patent: April 10, 2007
    Assignee: PharmaMar
    Inventors: Maria Flores, Andrés Francesch, Pilar Gallego, José Luis Chicharro, Maria Zarzuelo, Carolina Fernández, Ignacio Manzanares
  • Publication number: 20060292224
    Abstract: This invention relates to pharmaceutical formulations comprising particles with a substantially non-hygroscopic inner crystalline core and an outer coating comprising at least one bioactive molecule. The invention also relates to methods of forming particles comprising a substantially non-hygroscopic inner crystalline core and an outer coating comprising at least one bioactive molecule.
    Type: Application
    Filed: January 9, 2004
    Publication date: December 28, 2006
    Inventors: Barry Moore, Marie Parker, Johann Partridge, Jan Vos, Michaela Kreiner, Howard Steven, Maria Flores, Alistair Ross
  • Publication number: 20060106021
    Abstract: Derivatives of Et-743 or Et-770 or Et-729 are provided. The derivatives are of the general formula (Ia) wherein the substituent groups take various permitted meanings.
    Type: Application
    Filed: July 17, 2002
    Publication date: May 18, 2006
    Inventors: Valentin Martinez, Maria Flores, Pilar Gallego, Carmen Cuevas, Simon Munt, Ignacio Manzanares
  • Publication number: 20030216397
    Abstract: Compounds having a fused ecteinascidin five ring system with a 1,4 bridge having the structure of formula (VIa or VIb) and compounds in which the —NH2 or —OH of the 1,4 bridge is derivatised are disclosed. Such compounds are useful in the treatment of tumours.
    Type: Application
    Filed: March 19, 2003
    Publication date: November 20, 2003
    Inventors: Maria Flores, Andres Francesch, Gallego Pilar, Jose Luis Chicharro, Maria Zarzuelo, Carolina Fernandez, Ignacio Manzanares