Patents by Inventor Maria Flores
Maria Flores has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10870119Abstract: An apparatus is described. The apparatus comprises a liquid dispenser comprising a liquid outlet, the liquid dispenser being configured to generate a droplet stream. The apparatus also comprises a first fluid flow device configured to generate a confinement fluid flow for confining a trajectory of the droplet stream therein, the first fluid flow device comprising an outlet arranged to allow the droplet stream to exit therefrom, wherein the fluid outlet is arranged within the confinement fluid flow device. Furthermore, the apparatus comprises a second fluid flow device configured to generate a reaction fluid flow for reacting with droplets in the droplet stream, wherein the outlet of the first fluid flow device is arranged within the second fluid flow device. A method is also described.Type: GrantFiled: February 22, 2016Date of Patent: December 22, 2020Assignees: Ingeniatrics Tecnologías, Universidad de SevillaInventors: Miguel Angel Asensio Caño, Beatriz Talavera Almena, María Flores Mosquera, Alfonso Miguel Gañán-Calvo
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Patent number: 10730029Abstract: Concentric flow focusing encapsulation devices and methods for production of microencapsulated droplets of a first core material surrounded by a second shell material include assessment of non-dimensional fluid dynamic parameters that are related to the characteristics of produced droplets. The parameters are specifically related to characteristics such as homogenous or non-homogenous modes of concentric droplet breakup, density distribution of various droplet sizes, and qualities such as monodispersity of droplets produced. By identifying control parameters in specific regions, control variables may be selected to produce droplets or particles with desired qualities.Type: GrantFiled: September 28, 2016Date of Patent: August 4, 2020Assignees: INGENIATRICS TECNOLOGIAS, S.L., UNIVERSIDAD DE SEVILLAInventors: Alfonso Miguel Ganan-Calvo, Inmaculada Munoz, Jeronimo Escudero, Gloria Jurado, Antonio Serrano, Sandra Velazquez, Maria Flores Mosquera
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Publication number: 20180272306Abstract: Concentric flow focusing encapsulation devices and methods for production of microencapsulated droplets of a first core material surrounded by a second shell material include assessment of non-dimensional fluid dynamic parameters that are related to the characteristics of produced droplets. The parameters are specifically related to characteristics such as homogenous or non-homogenous modes of concentric droplet breakup, density distribution of various droplet sizes, and qualities such as monodispersity of droplets produced. By identifying control parameters in specific regions, control variables may be selected to produce droplets or particles with desired qualities.Type: ApplicationFiled: September 28, 2016Publication date: September 27, 2018Inventors: Alfonso Miguel GANAN-CALVO, Inmaculada MUNOZ, Jeronimo ESCUDERO, Gloria JURADO, Antonio SERRANO, Sandra VELAZQUEZ, Maria FLORES MOSQUERA
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Publication number: 20180029055Abstract: An apparatus is described. The apparatus comprises a liquid dispenser comprising a liquid outlet, the liquid dispenser being configured to generate a droplet stream. The apparatus also comprises a first fluid flow device configured to generate a confinement fluid flow for confining a trajectory of the droplet stream therein, the first fluid flow device comprising an outlet arranged to allow the droplet stream to exit therefrom, wherein the fluid outlet is arranged within the confinement fluid flow device. Furthermore, the apparatus comprises a second fluid flow device configured to generate a reaction fluid flow for reacting with droplets in the droplet stream, wherein the outlet of the first fluid flow device is arranged within the second fluid flow device. A method is also described.Type: ApplicationFiled: February 22, 2016Publication date: February 1, 2018Inventors: Miguel Angel ASENSIO CAÑO, Beatriz TALAVERA ALMENA, María FLORES MOSQUERA, Alfonso Miguel GAÑÁN-CALVO
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Patent number: 9382659Abstract: An aqueous printing ink and coating composition contains colorant, one or more high molecular weight starches and one or more water soluble acrylic polymers or co-polymers.Type: GrantFiled: December 2, 2005Date of Patent: July 5, 2016Assignee: Sun Chemical CorporationInventors: Sabino Apostol, Robert Catena, Alexander Chudolij, Ana Maria A. Flores, Mathew C. Mathew, Leda Mora, Jeannette Simoni-Truncellito
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Patent number: 8076337Abstract: Derivatives of Et-743 or Et-770 or Et-729 are provided. The derivatives are of the general formula Ia.: wherein the substituent groups take various permitted meanings.Type: GrantFiled: April 6, 2010Date of Patent: December 13, 2011Assignee: Pharma Mar, S.A.Inventors: Valentin Martinez, Maria Flores, Pilar Gallego, Carmen Cuevas, Simon Munt, Ignacio Manzanares
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Patent number: 7919493Abstract: This invention relates to antitumoral ecteinascidin derivatives that contain a fused ecteinascidin five ring system with a 1,4-bridge having the structure of formula (VIa) or (VIb) as described herein and compounds in which the —NH2 or —OH of the 1,4-bridge is derivatized, and related pharmaceutical compositions and methods. Such ecteinascidin derivatives include, but are not limited to, those compounds having formula (XVIIb): in which R1 and R4 together form a group of formula (VIa) or (VIb) as described herein, and R5, R7, R8, R14a, R14b, R15, and R21 are as defined herein.Type: GrantFiled: April 10, 2007Date of Patent: April 5, 2011Assignee: Pharma Mar, S.A.Inventors: Maria Flores, Andres Francesh, Pilar Gallego, Jose Luis Chicharro, Maria Zarzuelo, Carolina Fernandez, Ignacio Manzanares
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Publication number: 20100197695Abstract: Derivatives of Et-743 or Et-770 or Et-729 are provided. The derivatives are of the general formula Ia.: wherein the substituent groups take various permitted meanings.Type: ApplicationFiled: April 6, 2010Publication date: August 5, 2010Inventors: Valentin Martinez, Maria Flores, Pilar Gallego, Carmen Cuevas, Simon Munt, Ignacio Manzanares
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Patent number: 7759345Abstract: Derivatives of Et-743 or Et-770 or Et-729 are provided. The derivatives are of the general formula (Ia) wherein the substituent groups take various permitted meanings.Type: GrantFiled: July 17, 2002Date of Patent: July 20, 2010Assignee: Pharma Mar, S.A.Inventors: Valentin Martinez, Maria Flores, Pilar Gallego, Carmen Cuevas, Simon Munt, Ignacio Manzanares
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Publication number: 20090215154Abstract: The invention relates to a method of obtaining micro- and nanometric polymeric particles in a controlled, reproducible manner. The aforementioned particles have a spherical shape and a very narrow, uniform size distribution. The invention comprises the use of an easy particle-forming method consisting in using hydrodynamic forces to focus a composite microjet formed by two concentric fluids and can be used in the encapsulation of fragile compounds of biological interest, from peptides and proteins to cells and micro-organisms.Type: ApplicationFiled: May 3, 2006Publication date: August 27, 2009Inventors: Miguel Alfonso Ganan Calvo, Sebastien Chavez De Diego, Angel Cebolla Ramirez, Maria Flores Mosquera, Elena De Castro Hernandez
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Publication number: 20090214655Abstract: The invention relates to a method and device for obtaining micro and nanometric particles in a controlled, reproducible manner. The aforementioned particles have a spherical shape and a very narrow, uniform size distribution. More specifically, the invention relates to a novel method of forming emulsions and to the application thereof in micro and nanoencapsulation techniques involving the extraction/evaporation of the solvent. In particular, the invention relates to the encapsulation of the fluorescent compounds and the subsequent application thereof.Type: ApplicationFiled: January 26, 2006Publication date: August 27, 2009Inventors: Alfonso Miguel Ganan Calvo, Lucia Martin Banderas, Maria Flores Mosquera, Alfonso Rodriguez Gil, Sebastian Chavez De Diego, Angel Cebolla Ramirez
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Publication number: 20080146580Abstract: This invention relates to antitumoral ecteinascidin derivatives.Type: ApplicationFiled: April 10, 2007Publication date: June 19, 2008Applicant: PHARMAMARInventors: Maria Flores, Andres Francesh, Pilar Gallego, Jose Luis Chicharro, Maria Zarzuelo, Carolina Fernandez, Ignacio Manzanares
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Publication number: 20070289486Abstract: An aqueous printing ink and coating composition contains colorant, one or more high molecular weight starches and one or more water soluble acrylic polymers or co-polymers.Type: ApplicationFiled: December 2, 2005Publication date: December 20, 2007Applicant: SUN CHEMICAL CORPORATIONInventors: Sabino Apostol, Robert Catena, Jeannette Simoni-Truncellito, Alexander Chudolij, Ana Maria Flores, Mathew Mathew, Leda Mora
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Patent number: 7202361Abstract: This invention relates to compounds of the formula: wherein: the substituent groups defined by R1, R2 are each independently selected of H, C(?O)R?, C1–C18 alkyl, C2–C18 alkenyl, C2–C18 alkynyl, or aryl; each of the R? groups is independently selected from the group consisting of H; OH; NO2; NH2; SH; CN; halogen; ?O; C(?O)H; C(?O)CH3; CO2H; or C1–C18 alkyl, C2–C18 alkenyl, C2–C18 alkynyl, or aryl, each of which, independently, may be substituted with one or more substituents selected from the group consisting of halogen, cyano, hydroxy, nitro, azido; alkanoyl, carboxamido, alkyl, alkenyl, alkynyl, aryloxy, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, aminoalkyl, carbocylic aryl having 6 or more carbons, and aralkyl; X2 is OX1 or N(X1)2 wherein each X1 is independently H, C(?O)R? where R? is as defined, C1–C18 alkyl, C2–C18 alkenyl, C2–C18 alkynyl, aryl, alkoxy, heterocyclyl, or two X1 groups together form a cyclic substituent on the nitrogen atom, or X1 is SO2CH3 when X2 is OX1, or N(X1)2 is NHCOalkType: GrantFiled: April 12, 2001Date of Patent: April 10, 2007Assignee: PharmaMarInventors: Maria Flores, Andrés Francesch, Pilar Gallego, José Luis Chicharro, Maria Zarzuelo, Carolina Fernández, Ignacio Manzanares
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Publication number: 20060292224Abstract: This invention relates to pharmaceutical formulations comprising particles with a substantially non-hygroscopic inner crystalline core and an outer coating comprising at least one bioactive molecule. The invention also relates to methods of forming particles comprising a substantially non-hygroscopic inner crystalline core and an outer coating comprising at least one bioactive molecule.Type: ApplicationFiled: January 9, 2004Publication date: December 28, 2006Inventors: Barry Moore, Marie Parker, Johann Partridge, Jan Vos, Michaela Kreiner, Howard Steven, Maria Flores, Alistair Ross
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Publication number: 20060106021Abstract: Derivatives of Et-743 or Et-770 or Et-729 are provided. The derivatives are of the general formula (Ia) wherein the substituent groups take various permitted meanings.Type: ApplicationFiled: July 17, 2002Publication date: May 18, 2006Inventors: Valentin Martinez, Maria Flores, Pilar Gallego, Carmen Cuevas, Simon Munt, Ignacio Manzanares
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Publication number: 20030216397Abstract: Compounds having a fused ecteinascidin five ring system with a 1,4 bridge having the structure of formula (VIa or VIb) and compounds in which the —NH2 or —OH of the 1,4 bridge is derivatised are disclosed. Such compounds are useful in the treatment of tumours.Type: ApplicationFiled: March 19, 2003Publication date: November 20, 2003Inventors: Maria Flores, Andres Francesch, Gallego Pilar, Jose Luis Chicharro, Maria Zarzuelo, Carolina Fernandez, Ignacio Manzanares