Patents by Inventor Maria Gaczynska

Maria Gaczynska has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PEPTIDE-BASED COMPOSITIONS AND METHODS FOR TREATING ALZHEIMER'S DISEASE
    Publication number: 20220332758
    Abstract: Disclosed herein, are peptides capable of activating proteasome activity, and pharmaceutical compositions containing the peptides and methods treating Alzheimer's disease. Disclosed herein are compositions comprising: A) a peptide, wherein the peptide comprises the amino acid sequence GRKKR-RQ-AibG-RPS (SEQ ID NO: 4), or a fragment or variant thereof, B) a peptide, wherein the peptide comprises the amino acid sequence GRKKRRQ-AibG-QR-RKKRG (SEQ ID NO: 5), or a fragment or variant thereof, or C) a peptide, wherein the peptide comprises the amino acid sequence KKK/KKK-DABA-K KK (SEQ ID NO: 6) or a fragment or variant thereof.
    Type: Application
    Filed: September 11, 2020
    Publication date: October 20, 2022
    Inventors: Pawel A. OSMULSKI, Maria Gaczynska, Andrew Pickering, Przemyslaw Karpowicz, Elzbieta Jankowska
  • Pipecolic esters for inhibition of the proteasome
    Patent number: 11345659
    Abstract: The present disclosure relates to chemical compounds that modulate proteasome activity, pharmaceutical compositions containing such compounds, and use of these compounds and compositions for the treatment of disorders of uncontrolled cellular proliferation such as, for example, a cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: January 30, 2019
    Date of Patent: May 31, 2022
    Assignees: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
    Inventors: Maria Gaczynska, Pawel A. Osmulski, Jetze Tepe, Matt Giletto
  • PIPECOLIC ESTERS FOR INHIBITION OF THE PROTEASOME
    Publication number: 20210002220
    Abstract: The present disclosure relates to chemical compounds that modulate proteasome activity, pharmaceutical compositions containing such compounds, and use of these compounds and compositions for the treatment of disorders of uncontrolled cellular proliferation such as, for example, a cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: January 30, 2019
    Publication date: January 7, 2021
    Inventors: Maria Gaczynska, Pawel A. Osmulski, Jetze Tepe, Matt Giletto