Patents by Inventor Maria Grazia Mazzone

Maria Grazia Mazzone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230338540
    Abstract: The present invention relates to formulations for ophthalmic use characterized by a reduced dosage regimen.
    Type: Application
    Filed: February 5, 2021
    Publication date: October 26, 2023
    Inventors: Maria Grazia Mazzone, Claudine CIVIALE, Andrea SUDANO ROCCARO, Elena SOLFATO, Ilenia ABBATE, Maria CURATOLO
  • Publication number: 20230047895
    Abstract: The present invention relates to a sterile buffered eye topical composition containing metabolites of the fermentation of Lactobacillus pertaining to the species casei or paracasei and for ophthalmic use of the composition in the prevention or treatment of microbial eye infections, eye allergies, vernal keratoconjunctivitis and keratoconjunctivitis sicca and blepharitis.
    Type: Application
    Filed: December 4, 2020
    Publication date: February 16, 2023
    Inventors: Elena SOLFATO, Andrea SUDANO ROCCARO, Cristina Maria Concetta ZAPPULLA, Carmela Giovanna SPOTO, Donato SPINA, Veronica PEPE, Manuela SANTONOCITO, Angelo PRICOCO, Santa VIOLA, Maria Cristina CURATOLO, Maria Grazia MAZZONE, Giuseppe DE PASQUALE, Francesco GIULIANO
  • Publication number: 20160166601
    Abstract: The present invention relates to the use of xanthan gum as re-epithelializing agent and, in particular, to a pharmaceutical formulation comprising xanthan gum as a re-epithelializing active principle eventually mixed with hyaluronic acid. Said use and composition speed up and improve advantageously the formation of newly grown epithelium.
    Type: Application
    Filed: February 25, 2016
    Publication date: June 16, 2016
    Inventors: Maria Grazia Mazzone, Grazia Paladino, Clara Marino, Ornella Peri, Vincenzo Enea
  • Patent number: 9161906
    Abstract: The present invention refers to pharmaceutical formulations based on lipids for ophthalmic use comprising a phospholipid component composed of zwitterionic phospholipids of natural origin and an oily component composed of oils of natural origin emulsified in water. In particular, the invention refers to ophthalmic formulations useful, for example, for transporting drugs to the eye and in the treatment of ocular dryness, capable of restoring the lipid layer of the tear film. In particular, in a non-transitory but pathological situation such as the dry eye syndrome, such formulations also succeed in reducing the often-present inflammatory component.
    Type: Grant
    Filed: December 24, 2007
    Date of Patent: October 20, 2015
    Assignee: SIFI, S.P.A.
    Inventors: Maria Grazia Mazzone, Valeria Maria Carmela Moschetti, Fausto Giuseppe Miano, Letizia Gaetana Lo Grasso
  • Patent number: 8912164
    Abstract: The present invention relates to a pharmaceutical formulation comprising xanthan gum as a re-epithelializing active principle optionally mixed with hyaluronic acid. The composition speeds up and improves advantageously the formation of newly grown epithelium.
    Type: Grant
    Filed: April 24, 2003
    Date of Patent: December 16, 2014
    Assignee: SIFI S.p.A.
    Inventors: Maria Grazia Mazzone, Grazia Paladino, Clara Marino, Ornella Peri, Vincenzo Enea
  • Publication number: 20110142923
    Abstract: The present invention relates to ophthalmic pharmaceutical compositions comprising Sorafenib, its derivatives or active metabolites, for the treatment and prevention of ocular neoangiogenic pathologies.
    Type: Application
    Filed: August 6, 2009
    Publication date: June 16, 2011
    Inventors: Maria Grazia Mazzone, Vincenzo Papa, Francesco Giuliano, Manuela Marrano
  • Publication number: 20110117189
    Abstract: New compositions for ophthalmic use for the prevention and therapy of pathologies of the posterior segment of the eye. These compositions utilize xanthan gum as an active principle carrier, and can be advantageously administered as liquid-gel eye drops on the surface of the eye and optionally used in combination with other therapies for the treatment of the same pathologies.
    Type: Application
    Filed: July 8, 2008
    Publication date: May 19, 2011
    Applicant: S.I.F.I. Societa' Industria Farmaceutica Italiana S.P.A.
    Inventors: Maria Grazia Mazzone, Claudine Civiale, Francesco Cuffari
  • Publication number: 20090221545
    Abstract: The present invention relates in general to the use of amphiphilic graft-type copolymers of polyaspartamide for the ophthalmic administration of drugs, such as for example steroidal and non-steroidal anti-inflammatory agents, antimicrobial agents such as aminoglycosides, macrolides, cephalosporin, tetracycline, quinolones, penicillin, beta-lactams, anti-glaucoma agents such as prostaglandins, alpha- and beta-blockers, inhibitors of carbonic anhydrase, cannabinoids, antiviral agents, diagnostic agents, anti-angiogenic agents, antioxidants.
    Type: Application
    Filed: March 15, 2007
    Publication date: September 3, 2009
    Applicant: SIFI S.P.A.
    Inventors: Gaetano Giammona, Gennara Cavallaro, Mariano Licciardi, Claudine Civiale, Grazia Maria Paladino, Maria Grazia Mazzone
  • Publication number: 20080146530
    Abstract: The present invention relates to the use of xanthan gum as re-epithelializing agent and, in particular, to a pharmaceutical formulation comprising xanthan gum as a re-epithelializing active principle eventually mixed with hyaluronic acid. Said use and composition speed up and improve advantageously the formation of newly grown epithelium.
    Type: Application
    Filed: February 14, 2008
    Publication date: June 19, 2008
    Applicant: SIFI S.p.A.
    Inventors: Maria Grazia MAZZONE, Grazia Paladino, Clara Marino, Ornella Peri, Vincenzo Enea
  • Publication number: 20080139502
    Abstract: The present invention relates to the use of xanthan gum as re-epithelializing agent and, in particular, to a pharmaceutical formulation comprising xanthan gum as a re-epithelializing active principle eventually mixed with hyaluronic acid. Said use and composition speed up and improve advantageously the formation of newly grown epithelium.
    Type: Application
    Filed: February 14, 2008
    Publication date: June 12, 2008
    Applicant: SIFI S.p.A.
    Inventors: Maria Grazia Mazzone, Grazia Paladino, Clara Marino, Ornella Peri, Vincenzo Enea
  • Publication number: 20080139522
    Abstract: The present invention relates to the use of xanthan gum as re-epithelializing agent and, in particular, to a pharmaceutical formulation comprising xanthan gum as a re-epithelializing active principle eventually mixed with hyaluronic acid. Said use and composition speed up and improve advantageously the formation of newly grown epithelium.
    Type: Application
    Filed: February 14, 2008
    Publication date: June 12, 2008
    Applicant: SIFI S.p.A..
    Inventors: Maria Grazia Mazzone, Grazia Paladino, Clara Marino, Ornella Peri, Vincenzo Enea
  • Publication number: 20030109422
    Abstract: The present invention relates to a process for the preparation of pharmaceutical formulations containing the glycoprotein lactoferrin and/or its peptide fragments in therapeutical quantities, in which said process is performed at a temperature between 0 and 25° C.
    Type: Application
    Filed: August 14, 2002
    Publication date: June 12, 2003
    Applicant: SIFI S.p.A.
    Inventors: Maria Grazia Mazzone, Manuela Marrano, Antonino Asero, Grazia Paladino, Clara Marino, Anna Rita Blanco, Carla Amico, Vincenzo Enea
  • Patent number: 6277829
    Abstract: The present invention describes a process for the preparation of aqueous formulations containing azithromycin for ophthalmic use, as well any formulations obtained by this process and their topical use in the ocular bacterial infections, more preferably in the treatment of conjunctivitis, keratitis and blepharitis.
    Type: Grant
    Filed: December 27, 1999
    Date of Patent: August 21, 2001
    Assignee: S.I.F.I. Societa Industria Farmaceutica Italiana S.p.A.
    Inventors: Antonino Asero, Maria Grazia Mazzone, Valeria Moschetti, Anna Rita Blanco