Patents by Inventor Maria Grazia Perrone

Maria Grazia Perrone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12011433
    Abstract: The invention relates to a new class of compounds targeting COX-1. The invention also relates to the use of some of such compounds as a tool to investigate the structure and function of the enzyme, in the treatment targeting COX-1 or detection of COX-1 in relating disorders or diseases such as cancer and neuroinflammation, in particular in neurological (e.g. autism spectrum disorders) and neurodegenerative diseases (e.g. Alzheimer's diseases, Parkinson's diseases, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), traumatic brain injury (TBI), HIV dementia and prion diseases), and in gynecological tumor (e.g. ovarian cancer), neck and head tumor, and haematological tumors (e.g. multiple myeloma) and in the detection of COX-1 in “in vitro” (cells and tissues) and in “in vivo”.
    Type: Grant
    Filed: October 2, 2020
    Date of Patent: June 18, 2024
    Assignee: ITEL Telecomunicazioni S.r.l.
    Inventors: Antonio Scilimati, Maria Grazia Perrone, Paola Vitale
  • Publication number: 20240069015
    Abstract: The present invention relates to a device for identifying and monitoring possible environmental contamination by pathogenic and non-pathogenic microorganisms, e.g., viruses. The present invention further relates to a system comprising said device.
    Type: Application
    Filed: January 4, 2022
    Publication date: February 29, 2024
    Inventors: Antonio SCILIMATI, Maria Grazia PERRONE, Antonio GNONI, Salvatore Maria SCACCO, Michele DIAFERIA, Vincenzo DIMICCOLI, Anna TOLOMEO, Antonio RIGLIETTI, Davide SCILIMATI
  • Publication number: 20230203593
    Abstract: The present invention relates to a method for performing an in vitro molecular diagnosis of ovarian cancer in a subject. Furthermore, the present invention relates to a kit allowing to perform an in vitro diagnosis of ovarian cancer.
    Type: Application
    Filed: May 19, 2021
    Publication date: June 29, 2023
    Inventors: Antonio SCILIMATI, Maria Grazia PERRONE, Savina FERORELLI, Anna Maria DE GRASSI, Giuseppe PERRONE, Francesca ZALFA, Michele DIAFERIA, Vincenzo DIMICCOLI
  • Publication number: 20210023055
    Abstract: The invention relates to a new class of compounds targeting COX-1. The invention also relates to the use of some of such compounds as a tool to investigate the structure and function of the enzyme, in the treatment targeting COX-1 or detection of COX-1 in relating disorders or diseases such as cancer and neuroinflammation, in particular in neurological (e.g. autism spectrum disorders) and neurodegenerative diseases (e.g. Alzheimer's diseases, Parkinson's diseases, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), traumatic brain injury (TBI), HIV dementia and prion diseases), and in gynecological tumor (e.g. ovarian cancer), neck and head tumor, and haematological tumors (e.g. multiple myeloma) and in the detection of COX-1 in “in vitro” (cells and tissues) and in “in vivo”.
    Type: Application
    Filed: October 2, 2020
    Publication date: January 28, 2021
    Inventors: Antonio SCILIMATI, Maria Grazia PERRONE, Paola VITALE
  • Publication number: 20190111025
    Abstract: Multi-functions Selective COX inhibitors The invention relates to a new class of compounds targeting COX-1. The invention also relates to the use of some of such compounds as a tool to investigate the structure and function of the enzyme, in the treatment targeting COX-1 or detection of COX-1 in relating disorders or diseases such as cancer and neuroinflammation, in particular in neurological (e.g. autism spectrum disorders) and neurodegenerative diseases (e.g. Alzheimer's diseases, Parkinson's diseases, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), traumatic brain injury (TBI), HIV dementia and prion diseases), and in gynecological tumour (e.g. ovarian cancer), neck and head tumor, and haematological tumours (e.g. multiple myeloma) and in the detection of COX-1 in “in vitro” (cells and tissues) and in “in vivo”.
    Type: Application
    Filed: April 26, 2017
    Publication date: April 18, 2019
    Inventors: Antonio SCILIMATI, Maria Grazia PERRONE, Paola VITALE
  • Patent number: 8354412
    Abstract: The present invention relates to new compounds, ligands of the beta-3 adrenergic receptor, their preparation and their use in therapy or as research tools for said receptor; the invention also relates to a process for the preparation of the compounds of the invention and the use of inverse agonists of the beta-3 adrenergic receptor as medicaments.
    Type: Grant
    Filed: August 3, 2011
    Date of Patent: January 15, 2013
    Assignee: Universita' Degli Studi di Bari
    Inventors: Antonio Scilimati, Maria Grazia Perrone, Ernesto Santandrea
  • Publication number: 20110288104
    Abstract: The present invention relates to new compounds, ligands of the beta-3 adrenergic receptor, their preparation and their use in therapy or as research tools for said receptor; the invention also relates to a process for the preparation of the compounds of the invention and the use of inverse agonists of the beta-3 adrenergic receptor as medicaments.
    Type: Application
    Filed: August 3, 2011
    Publication date: November 24, 2011
    Applicant: UNIVERSITA' DEGLI STUDI DI BARI
    Inventors: Antonio Scilimati, Maria Grazia Perrone, Ernesto Santandrea
  • Patent number: 8017613
    Abstract: The present invention relates to new compounds, ligands of the beta-3 adrenergic receptor, their preparation and their use in therapy or as research tools for said receptor; the invention also relates to a process for the preparation of the compounds of the invention and the use of inverse agonists of the beta-3 adrenergic receptor as medicaments.
    Type: Grant
    Filed: August 3, 2007
    Date of Patent: September 13, 2011
    Assignee: Universita' Degli Studi Di Bari
    Inventors: Antonio Scilimati, Maria Grazia Perrone, Ernesto Santandrea
  • Publication number: 20100075977
    Abstract: The present invention relates to new compounds, ligands of the beta-3 adrenergic receptor, their preparation and their use in therapy or as research tools for said receptor; the invention also relates to a process for the preparation of the compounds of the invention and the use of inverse agonists of the beta-3 adrenergic receptor as medicaments.
    Type: Application
    Filed: August 3, 2007
    Publication date: March 25, 2010
    Inventors: Antonio Scilimati, Maria Grazia Perrone, Ernesto Santandrea