Patents by Inventor Maria Graziella Larm
Maria Graziella Larm has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9492384Abstract: An oil in water microemulsion or sub-micron emulsion composition for dermal delivery of desonide is provided, along with a method of medical or cosmetic treatment of a dermal condition using the composition. The composition includes desonide; an oil phase dispersed throughout a water phase, the oil phase including at least one member selected from the group consisting of an animal oil, a mineral oil, a vegetable oil, a silane member, a siloxane, an ester, a fatty acid, a fat, a halogen compound, and an alkoxylated alcohol; and at least one lipophilic surfactant, the water phase including at least one hydrophilic surfactant and water; and a non-surfactant amphiphilic compound that is miscible in the water phase and added to the composition after formation of the microemulsion or sub-micron emulsion; wherein the desonide is in the water phase or both the water phase and the oil phase.Type: GrantFiled: February 24, 2015Date of Patent: November 15, 2016Assignee: STIEFEL WEST COAST LLCInventors: Maria Graziella Larm, Ronald Harding, Michael Johnston, Albert Zorko Abram, Prema Viyayakumar, Phoebe Sun
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Publication number: 20160166487Abstract: The present invention provides for 4-[hydroxy(diphenyl)methyl]-1-{2-[(phenylmethyl)oxy]ethyl}-1-azoniabicyclo[2.2.2]octane and a pharmaceutically acceptable anion thereof for use in the topical treatment or prophylaxis of excessive sweating, and compositions containing these ingredients.Type: ApplicationFiled: July 30, 2014Publication date: June 16, 2016Inventors: Teodora PENE DUMITRESCU, Elizabeth K. HUSSEY, Maria Graziella LARM, Jon D. LENN, Leon LOUPENOK, Michael R. LUKE, Leandro L. SANTOS, Virginia D. SCHMITH
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Publication number: 20150258023Abstract: An oil in water microemulsion or sub-micron emulsion composition for dermal delivery of at least one pharmaceutically active ingredient, is provided. The composition includes an oil phase dispersed throughout a water phase, the oil phase including at least one member selected from the group consisting of an animal oil, a mineral oil, a vegetable oil, a silane member, a siloxane, an ester, a fatty acid, a fat, a halogen compound, and an alkoxylated alcohol; and at least one lipophilic surfactant, the water phase including at least one hydrophilic surfactant, water and optionally a non-surfactant amphiphilic compound, the weight ratio of the at least one hydrophilic surfactant to the at least one lipophilic surfactant being approximately 9.0:1.0 to 2.0:3.0.Type: ApplicationFiled: February 24, 2015Publication date: September 17, 2015Inventors: Maria Graziella LARM, Ronald HARDING, Michael JOHNSTON, Albert Zorko ABRAM, Prema VIYAYAKUMAR, Phoebe SUN
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Patent number: 8962000Abstract: An oil in water microemulsion or sub-micron emulsion composition for dermal delivery of at least one pharmaceutically active ingredient, is provided. The composition includes an oil phase dispersed throughout a water phase, the oil phase including at least one member selected from the group consisting of an animal oil, a mineral oil, a vegetable oil, a silane member, a siloxane, an ester, a fatty acid, a fat, a halogen compound, and an alkoxylated alcohol; and at least one lipophilic surfactant, the water phase including at least one hydrophilic surfactant, water and optionally a non-surfactant amphiphilic compound, the weight ratio of the at least one hydrophilic surfactant to the at least one lipophilic surfactant being approximately 9.0:1.0 to 2.0:3.0.Type: GrantFiled: April 30, 2013Date of Patent: February 24, 2015Assignee: Stiefel West Coast LLCInventors: Maria Graziella Larm, Ronald Harding, Michael Johnston, Albert Zorko Abram, Prema Viyayakumar, Phoebe Sun
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Publication number: 20150037269Abstract: The present invention provides for 4-[hydroxy(diphenyl)methyl]-1-{2-[(phenylmethyl)oxy]ethyl}-1-azoniabicyclo[2.2.2]octane and a pharmaceutically acceptable anion thereof for use in the topical treatment or prophylaxis of excessive sweating, and compositions containing these ingredients.Type: ApplicationFiled: July 30, 2014Publication date: February 5, 2015Inventors: Teodora Pene DUMITRESCU, Elizabeth K. HUSSEY, Maria Graziella LARM, Jon LENN, Leon LOUPENOK, Michael R. LUKE, Leandro L. SANTOS, Virginia D. SCHMITH
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Patent number: 8629128Abstract: A pharmaceutical aerosol foam composition, comprising: an effective amount of a pharmaceutically active ingredient, wherein said pharmaceutically active ingredient is a vitamin or analogue thereof; an occlusive agent; an aqueous solvent; an organic cosolvent; wherein the pharmaceutically active ingredient is insoluble in both water and the occlusive agent; and the occlusive agent being present in an amount sufficient to form an occlusive layer on the skin, in use. In a second embodiment, an oil-in water emulsion having a vitamin, an occlusive agent; an aqueous solvent; and an organic cosolvent, wherein the occlusive agent is present in an amount sufficient to form an occlusive layer on the skin.Type: GrantFiled: September 20, 2012Date of Patent: January 14, 2014Assignee: Stiefel West Coast, LLCInventors: Richard Buchta, Robert James Houlden, Maria Graziella Larm, Leon Loupenok, Rose Ye
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Patent number: 8460641Abstract: An oil-in-water microemulsion or sub-micron emulsion composition for dermal delivery of at least one pharmaceutically active ingredient, comprising: a first part including at least one occlusive agent and one or more lipophilic surfactants dispersed throughout a second part including water and at least one hydrophilic surfactant, and a non-surfactant amphiphilic type compound, pharmaceutically active ingredient, and water. It has been found that if a non-surfactant amphiphilic type compound is added together with the second part as would conventionally be the case, a microemulsion or sub-micron emulsion is not formed, by adding the so called third part, phase assembly occurs at a lower temperature than would be expected and moreover, this phase appears to assist in maintaining the microemulsion or sub-micron emulsion characteristics of the formulation during storage at normal temperatures.Type: GrantFiled: August 31, 2005Date of Patent: June 11, 2013Assignee: Stiefel Research Australia Pty LtdInventors: Maria Graziella Larm, Ronald Harding, Michael Johnston, Albert Zorko Abram, Prema Vijayakumar, Phoebe Sun
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Patent number: 8449867Abstract: An oil in water microemulsion or sub-micron emulsion composition for dermal delivery of at least one pharmaceutically active ingredient, is provided. The composition includes an oil phase dispersed throughout a water phase, the oil phase including at least one member selected from the group consisting of an animal oil, a mineral oil, a vegetable oil, a silane member, a siloxane, an ester, a fatty acid, a fat, a halogen compound, and an alkoxylated alcohol; and at least one lipophilic surfactant, the water phase including at least one hydrophilic surfactant, water and optionally a non-surfactant amphiphilic compound, the weight ratio of the at least one hydrophilic surfactant to the at least one lipophilic surfactant being approximately 9.0:1.0 to 2.0:3.0.Type: GrantFiled: June 25, 2009Date of Patent: May 28, 2013Assignee: Stiefel Research Australia Pty LtdInventors: Maria Graziella Larm, Ronald Harding, Michael Johnston, Albert Zorko Abram, Prema Vijayakumar, Phoebe Sun
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Publication number: 20130101525Abstract: A pharmaceutical aerosol foam composition, comprising: an effective amount of a pharmaceutically active ingredient, wherein said pharmaceutically active ingredient is a vitamin or analogue thereof; an occlusive agent; an aqueous solvent; an organic cosolvent; wherein the pharmaceutically active ingredient is insoluble in both water and the occlusive agent; and the occlusive agent being present in an amount sufficient to form an occlusive layer on the skin, in use. In a second embodiment, an oil-in water emulsion having a vitamin, an occlusive agent; an aqueous solvent; and an organic cosolvent, wherein the occlusive agent is present in an amount sufficient to form an occlusive layer on the skin.Type: ApplicationFiled: September 20, 2012Publication date: April 25, 2013Applicant: STIEFEL RESEARCH AUSTRALIA PTY LTDInventors: Richard BUCHTA, Robert James HOULDEN, Maria Graziella LARM, Leon LOUPENOK, Rose YE
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Patent number: 8298515Abstract: A pharmaceutical aerosol foam composition, comprising: an effective amount of a pharmaceutically active ingredient, wherein said pharmaceutically active ingredient is a vitamin or analogue thereof; an occlusive agent; an aqueous solvent; an organic cosolvent; wherein the pharmaceutically active ingredient is insoluble in both water and the occlusive agent; and the occlusive agent being present in an amount sufficient to form an occlusive layer on the skin, in use. In a second embodiment, an oil-in water emulsion having a vitamin, an occlusive agent; an aqueous solvent; and an organic cosolvent, wherein the occlusive agent is present in an amount sufficient to form an occlusive layer on the skin.Type: GrantFiled: September 28, 2010Date of Patent: October 30, 2012Assignee: Stiefel Research Australia Pty Ltd.Inventors: Richard Buchta, Robert James Houlden, Maria Graziella Larm, Leon Loupenok, Rose Ye
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Patent number: 8263580Abstract: A pharmaceutical aerosol foam composition, comprising: an effective amount of a pharmaceutically active ingredient, wherein said pharmaceutically active ingredient is a vitamin or analogue thereof; an occlusive agent; an aqueous solvent; an organic cosolvent; wherein the pharmaceutically active ingredient is insoluble in both water and the occlusive agent; and the occlusive agent being present in an amount sufficient to form an occlusive layer on the skin, in use. In a second embodiment, an oil-in water emulsion having a vitamin, an occlusive agent; an aqueous solvent; and an organic cosolvent, wherein the occlusive agent is present in an amount sufficient to form an occlusive layer on the skin.Type: GrantFiled: May 26, 2006Date of Patent: September 11, 2012Assignee: Stiefel Research Australia Pty LtdInventors: Richard Buchta, Robert James Houlden, Rose Ye, Maria Graziella Larm, Leon Loupenok
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Publication number: 20100055137Abstract: An oil in water microemulsion or sub-micron emulsion composition for dermal delivery of at least one pharmaceutically active ingredient, is provided. The composition includes an oil phase dispersed throughout a water phase, the oil phase including at least one member selected from the group consisting of an animal oil, a mineral oil, a vegetable oil, a silane member, a siloxane, an ester, a fatty acid, a fat, a halogen compound, and an alkoxylated alcohol; and at least one lipophilic surfactant, the water phase including at least one hydrophilic surfactant, water and optionally a non-surfactant amphiphilic compound, the weight ratio of the at least one hydrophilic surfactant to the at least one lipophilic surfactant being approximately 9.0:1.0 to 2.0:3.0.Type: ApplicationFiled: June 25, 2009Publication date: March 4, 2010Applicant: STIEFEL RESEARCH AUSTRALIA PTY LTDInventors: Maria Graziella Larm, Ronald Harding, Michael Johnston, Albert Zorko Abram, Prema Vijayakumar, Phoebe Sun