Patents by Inventor Maria Henderikx

Maria Henderikx has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alphabody libraries and methods for producing the same
    Patent number: 10087249
    Abstract: The invention provides single-chain Alphabody library comprising at least 100 different-sequence single-chain Alphabody polypeptides, wherein said Alphabody polypeptides differ from each other in at least one of a defined set of 5 to 20 variegated amino acid residue positions, and wherein at least 70% but not all of said variegated amino acid residue positions are located either in the loop, helix surface or linker region of the Alphabody. The invention further provides methods for use of the Alphabody libraries and Alphabodies obtainable by the methods of the invention.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: October 2, 2018
    Assignee: COMPLIX SA
    Inventors: Johan Desmet, Ignace Lasters, Maria Henderikx, Anita Wehnert
  • ALPHABODY LIBRARIES AND METHODS FOR PRODUCING THE SAME
    Publication number: 20160326242
    Abstract: The invention provides single-chain Alphabody library comprising at least 100 different-sequence single-chain Alphabody polypeptides, wherein said Alphabody polypeptides differ from each other in at least one of a defined set of 5 to 20 variegated amino acid residue positions, and wherein at least 70% but not all of said variegated amino acid residue positions are located either in the loop, helix surface or linker region of the Alphabody. The invention further provides methods for use of the Alphabody libraries and Alphabodies obtainable by the methods of the invention.
    Type: Application
    Filed: March 11, 2016
    Publication date: November 10, 2016
    Inventors: Johan Desmet, Ignace Lasters, Maria Henderikx, Anita Wehnert
  • Alphabody libraries and methods for producing the same
    Patent number: 9315805
    Abstract: The invention provides single-chain Alphabody library comprising at least 100 different-sequence single-chain Alphabody polypeptides, wherein said Alphabody polypeptides differ from each other in at least one of a defined set of 5 to 20 variegated amino acid residue positions, and wherein at least 70% but not all of said variegated amino acid residue positions are located either in the loop, helix surface or linker region of the Alphabody. The invention further provides methods for use of the Alphabody libraries and Alphabodies obtainable by the methods of the invention.
    Type: Grant
    Filed: January 6, 2011
    Date of Patent: April 19, 2016
    Assignee: Complix SA
    Inventors: Johan Desmet, Ignace Lasters, Maria Henderikx, Anita Wehnert
  • Method for treating breast cancer using antibody binding to MMP-14
    Patent number: 9051377
    Abstract: Proteins that bind to matrix metalloproteinase 14 and methods of using such proteins are described.
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: June 9, 2015
    Assignee: Dyax Corp.
    Inventors: Laetitia Devy, Henk Pieters, Robert C. Ladner, Rene Hoet, Daniel T. Dransfield, Clive R. Wood, Maria Henderikx
  • ALPHABODY LIBRARIES AND METHODS FOR PRODUCING THE SAME
    Publication number: 20140066601
    Abstract: The invention provides single-chain Alphabody library comprising at least 100 different-sequence single-chain Alphabody polypeptides, wherein said Alphabody polypeptides differ from each other in at least one of a defined set of 5 to 20 variegated amino acid residue positions, and wherein at least 70% but not all of said variegated amino acid residue positions are located either in the loop, helix surface or linker region of the Alphabody. The invention further provides methods for use of the Alphabody libraries and Alphabodies obtainable by the methods of the invention.
    Type: Application
    Filed: January 6, 2011
    Publication date: March 6, 2014
    Inventors: Johan Desmet, Ignace Lasters, Maria Henderikx, Anita Wehnert
  • ALPHABODIES SPECIFICALLY BINDING TO CYTOKINES OR GROWTH FACTORS AND/OR CYTOKINE OR GROWTH FACTOR RECEPTORS
    Publication number: 20140057830
    Abstract: Alphabodies that specifically bind to cytokines or growth factor and/or their receptors, as well as polypeptides that comprise or essentially consist of such Alphabodies. Further nucleic acids encoding such Alphabodies; methods for preparing such Alphabodies and polypeptides; host cells expressing or capable of expressing such Alphabodies and polypeptides; compositions, and in particular pharmaceutical compositions, that comprise such Alphabodies, polypeptides, nucleic acids and/or host cells; and uses of such Alphabodies or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.
    Type: Application
    Filed: January 6, 2012
    Publication date: February 27, 2014
    Applicant: COMPLIX SA
    Inventors: Ignace Lasters, Johan Desmet, Maria Henderikx, Anita Wehnert, Geert Meersseman
  • METALLOPROTEINASE BINDING PROTEINS
    Publication number: 20120107231
    Abstract: Proteins that bind to matrix metalloproteinase 14 and methods of using such proteins are described.
    Type: Application
    Filed: December 22, 2011
    Publication date: May 3, 2012
    Applicant: DYAX CORP.
    Inventors: Laetitia Devy, Henk Pieters, Robert C. Ladner, Rene Hoet, Daniel T. Dransfield, Clive R. Wood, Maria Henderikx
  • Metalloproteinase binding proteins
    Patent number: 8106168
    Abstract: Proteins that bind to matrix metalloproteinase 14 and methods of using such proteins are described.
    Type: Grant
    Filed: May 7, 2010
    Date of Patent: January 31, 2012
    Assignee: Dyax Corp.
    Inventors: Laetitia Devy, Henk Pieters, Robert C. Ladner, Rene Hoet, Daniel T. Dransfield, Clive R. Wood, Maria Henderikx
  • Methods of using an antibody that binds to apolipoprotein e
    Patent number: 8058016
    Abstract: A human antibody fragment, which antibody or fragment: (i) binds to a polypeptide having the amino acid sequence shown in SEQ ID NO: 1 of the C-terminal domain of Apolipoprotein E (ApoE-CTD) or the amino acid sequence of a part thereof; and (ii) binds to human plaques.
    Type: Grant
    Filed: September 8, 2009
    Date of Patent: November 15, 2011
    Assignees: Astrazeneca AB, Dyax Corporation
    Inventors: Christer Nordstedt, Tom Goldschmidt, Maria Henderikx, René Hoet, Henricus Hoogenboom, Simon Hufton, Christin V. Andersson, Johanna Lindquist, Dan Sunnemark, Sergy Leonov
  • Metalloproteinase Binding Proteins
    Publication number: 20100266490
    Abstract: Proteins that bind to matrix metalloproteinase 14 and methods of using such proteins are described.
    Type: Application
    Filed: May 7, 2010
    Publication date: October 21, 2010
    Applicant: DYAX CORP.
    Inventors: Laetitia Devy, Henk Pieters, Robert C. Ladner, Rene Hoet, Daniel T. Dransfield, Clive R. Wood, Maria Henderikx
  • Antibodies that bind MMP-14
    Patent number: 7745587
    Abstract: Proteins that bind to matrix metalloproteinase 14 and methods of using such proteins are described.
    Type: Grant
    Filed: December 29, 2006
    Date of Patent: June 29, 2010
    Assignee: Dyax Corp.
    Inventors: Laetitia Devy, Henk Pieters, Robert C. Ladner, Rene Hoet, Daniel T. Dransfield, Clive R. Wood, Maria Henderikx
  • Antibodies
    Publication number: 20100061993
    Abstract: A human antibody fragment, which antibody or fragment: (i) binds to a polypeptide having the amino acid sequence shown in SEQ ID NO: 1 of the C-terminal domain of Apolipoprotein E (ApoE-CTD) or the amino acid sequence of a part thereof; and (ii) binds to human plaques.
    Type: Application
    Filed: September 8, 2009
    Publication date: March 11, 2010
    Applicants: ASTRAZENECA AB, DYAX CORPORATION
    Inventors: Christer Nordstedt, Tom Goldschmidt, Maria Henderikx, René Hoet, Henricus Hoogenboom, Simon Hufton, Christin V. Andersson, Johanna Lindquist, Dan Sunnemark, Sergy Leonov
  • antibodies binding to a C-terminal fragment of apoliopoprotein E
    Patent number: 7612179
    Abstract: A human antibody fragment, which antibody or fragment: (i) binds to a polypeptide having the amino acid sequence shown in SEQ ID NO: 1 of the C-terminal domain of Apolipoprotein E (ApoE-CTD) or the amino acid sequence of a part thereof; and (ii) binds to human plaques.
    Type: Grant
    Filed: November 26, 2004
    Date of Patent: November 3, 2009
    Assignees: Astrazeneca AB, Dyax Corporation
    Inventors: Christer Nordstedt, Tom Goldschmidt, Maria Henderikx, René Hoet, Henricus Hoogenboom, Simon Hufton, Christin V. Andersson, Johanna Lindquist, Dan Sunnemark, Sergy Leonov
  • Antibodies binding to a c-terminal fragment of apoliopoprotein e
    Publication number: 20070104715
    Abstract: A human antibody fragment, which antibody or fragment: (i) binds to a polypeptide having the amino acid sequence shown in SEQ ID NO: 1 of the C-terminal domain of Apolipoprotein E (ApoE-CTD) or the amino acid sequence of a part thereof; and (ii) binds to human plaques.
    Type: Application
    Filed: November 26, 2004
    Publication date: May 10, 2007
    Applicants: ASTRAZENECA AB, DYAX CORP.
    Inventors: Christer Nordstedt, Tom Goldschmidt, Maria Henderikx, Rene Hoet, Henricus Hoogenboom, Simon Hufton, Christian Andersson, Johanna Lindquist, Dan Sunnemark, Sergy Leonov