Patents by Inventor Maria J. M. Chen

Maria J. M. Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and Methods For Inducing Apoptosis In Tumor Cells
    Publication number: 20110015126
    Abstract: A method is described for using an E-domain peptide for the induction of apoptosis in a cancer cells. In particular, the invention relates to methods for using a-type E-domain peptide from trout IGF and/or a b-type E-domain peptide from human IGF for the induction of apoptosis in a broad spectrum of cancer cells. The peptide species can be a homologue of the E-domain of IGF-1 or a fusion protein comprising the E-domain of IGF-1. It can be administered to one or more cancer cells alone or in a pharmaceutically acceptable composition.
    Type: Application
    Filed: March 11, 2010
    Publication date: January 20, 2011
    Applicant: E-P THERAPEUTICS, INC.
    Inventors: Thomas T. Chen, Maria J.M. Chen
  • Compositions and methods for inducing apoptosis in tumor cells
    Patent number: 7700353
    Abstract: A method is described for using an E-domain peptide for the induction of apoptosis in a cancer cells. In particular, the invention relates to methods for using a-type E-domain peptide from trout IGF and/or a b-type E-domain peptide from human IGF for the induction of apoptosis in a broad spectrum of cancer cells. The peptide species can be a homologue of the E-domain of IGF-1 or a fusion protein comprising the E-domain of IGF-1. It can be administered to one or more cancer cells alone or in a pharmaceutically acceptable composition.
    Type: Grant
    Filed: February 15, 2006
    Date of Patent: April 20, 2010
    Assignee: E-P Therapeutics, Inc.
    Inventors: Thomas T. Chen, Maria J. M. Chen
  • Anti-tumor activity of Ea-4-peptide of pro-IGF-I
    Patent number: 7655462
    Abstract: Compositions of pro-IFG-I E-peptides for the treatment and amelioration of tumor-producing diseases, and methods for their utilization.
    Type: Grant
    Filed: May 2, 2007
    Date of Patent: February 2, 2010
    Assignee: E-P Therapeutics, Inc.
    Inventors: Thomas T. Chen, Maria J. M. Chen
  • COMPOSITIONS AND METHODS FOR PROMOTING TISSUE REPAIR AND WOUND HEALING
    Publication number: 20090318355
    Abstract: A method is described for using the Ea4-peptide of pro-IGF-I or human Eb-peptide of pro-IGF-I for enhancing the proliferation of fibroblasts and closure of wound. The peptide species can be homologous of trout Ea4-peptide, human Eb-peptide of pro-IGF-I or a fusion protein comprising the Ea4- or Eb-peptide of pro-IGF-I. It can be administered any wound in a pharmaceutically acceptable composition alone or in combination with other compounds.
    Type: Application
    Filed: May 13, 2009
    Publication date: December 24, 2009
    Inventors: Thomas T. Chen, Maria J.M. Chen
  • COMPOSITIONS AND METHODS FOR MODULATING CELL DIFFERENTIATION
    Publication number: 20090221072
    Abstract: Compositions and methods are described for using the Ea4-peptide of pro-IGF-I or human Eb-peptide of pro-IGF-I to inhibit hematopoiesis and to induce differentiation of neuroblastoma cells and neuronal stem cells.
    Type: Application
    Filed: May 13, 2009
    Publication date: September 3, 2009
    Inventors: Thomas T. Chen, Maria J.M. Chen
  • Anti-tumor activity of Ea-4-peptide of pro-IGF-1
    Patent number: 7250169
    Abstract: Compositions of pro-IFG-I E-peptides for the treatment and amelioration of tumor-producing diseases, and methods for their utilization.
    Type: Grant
    Filed: August 25, 2003
    Date of Patent: July 31, 2007
    Assignee: University of Connecticut
    Inventors: Thomas T. Chen, Maria J. M. Chen
  • Compositions and methods for inhibiting the proliferation and invasiveness of malignant cells comprising E-domain peptides of IGF-I
    Patent number: 7118752
    Abstract: A method is described for using an a-type or b-type E domain of the human or trout IGF peptide for the inhibition of proliferation and invasiveness of a broad spectrum of malignant cells and for the inhibition of angiogenesis. The peptide species can be a homologue of the E-domain of IGF-1 or a fusion protein comprising the E-domain of IGF-1. It can be administered to one or more malignant cells in a pharmaceutically acceptable composition, or alternatively, can be administered to one or more malignant cells by transforming the cells with exogenous nucleic acid that results in the expression of the E domain of IGF-1 in the cell.
    Type: Grant
    Filed: March 18, 2002
    Date of Patent: October 10, 2006
    Assignee: University of Connecticut
    Inventors: Thomas T. Chen, Maria J. M. Chen, Ya-Huei Kuo
  • Compositions and methods for inhibiting the proliferation and invasiveness of malignant cells comprising E-domain peptides of IGF-I
    Publication number: 20040116335
    Abstract: A method is described for using an a-type or b-type E domain of the human or trout IGF peptide for the inhibition of proliferation and invasiveness of a broad spectrum of malignant cells and for the inhibition of angiogenesis. The peptide species can be a homologue of the E-domain of IGF-1 or a fusion protein comprising the E-domain of IGF-1. It can be administered to one or more malignant cells in a pharmaceutically acceptable composition, or alternatively, can be administered to one or more malignant cells by transforming the cells with exogenous nucleic acid that results in the expression of the E domain of IGF-1 in the cell.
    Type: Application
    Filed: March 18, 2002
    Publication date: June 17, 2004
    Inventors: Thomas T. Chen, Maria J.M. Chen, Ya-Huei Kuo
  • Anti-tumor activity of Ea-2 and Ea-4-peptide of pro-IGF-I
    Patent number: 6610302
    Abstract: Compositions of pro-IFG-I E-peptides for the treatment and amelioration of tumor-producing diseases, and methods for their utilization.
    Type: Grant
    Filed: September 26, 2000
    Date of Patent: August 26, 2003
    Assignee: University of Connecticut
    Inventors: Thomas T. Chen, Maria J. M. Chen
  • Biological activity of IGF-I E domain peptide
    Patent number: 6358916
    Abstract: Methods of increasing mitosis in cells; of increasing cell attachment in culture; of enhancing wound healing; and of inhibiting proliferation of malignant cells, are described, comprising administering an E domain peptide from insulin-like growth factor I (IGF-I) of a trout, or administering an E domain peptide homolog, an E domain peptide fusion protein, or a nucleic acid encoding an E domain peptide, an E domain peptide homolog or an E domain peptide fusion protein.
    Type: Grant
    Filed: July 22, 1998
    Date of Patent: March 19, 2002
    Inventors: Thomas T. Chen, Maria J. M. Chen, Xiuchun Tian