Patents by Inventor Maria Johanna J.E. Van Driel

Maria Johanna J.E. Van Driel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polypeptide that binds aberrant cells and induces apoptosis
    Patent number: 9821073
    Abstract: Described are proteinaceous molecules comprising at least a domain that comprises an amino acid sequence that specifically binds to an MHC-peptide complex on an aberrant cell, functionally connected with a substance that induces apoptosis in aberrant cells, but not in normal cells. These proteinaceous molecules are preferably used in selectively modulating biological processes. The provided proteinaceous molecules are of particular use in pharmaceutical compositions for the treatment of diseases related to cellular aberrancies, such as cancers.
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: November 21, 2017
    Assignee: APO-T B.V.
    Inventors: Maria Johanna J. E. Van Driel, Johan Renes
  • Cross-linking polypeptide that induces apoptosis
    Patent number: 9512231
    Abstract: The disclosure relates to a polypeptide comprising at least four domains specifically binding to a certain MHC peptide complex, the domains separated by linker amino acid sequences, thereby providing each domain with the capability to bind a separate MHC peptide complex, to a nucleic acid encoding for such a polypeptide, to a vector comprising such a nucleic acid, to a host cell for expression of such a polypeptide, to a pharmaceutical composition comprising such a polypeptide, and to a kit of parts comprising at least two polypeptides according to the disclosure.
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: December 6, 2016
    Assignee: APO-T B.V.
    Inventors: Ralph Alexander Willemsen, Maria Johanna J. E. Van Driel
  • POLYPEPTIDE THAT BINDS ABERRANT CELLS AND INDUCES APOPTOSIS
    Publication number: 20140205599
    Abstract: Described are proteinaceous molecules comprising at least a domain that comprises an amino acid sequence that specifically binds to an MHC-peptide complex on an aberrant cell, functionally connected with a substance that induces apoptosis in aberrant cells, but not in normal cells. These proteinaceous molecules are preferably used in selectively modulating biological processes. The provided proteinaceous molecules are of particular use in pharmaceutical compositions for the treatment of diseases related to cellular aberrancies, such as cancers.
    Type: Application
    Filed: December 22, 2011
    Publication date: July 24, 2014
    Inventor: Maria Johanna J.E. Van Driel
  • CROSS-LINKING POLYPEPTIDE THAT INDUCES APOPTOSIS
    Publication number: 20140120090
    Abstract: The disclosure relates to a polypeptide comprising at least four domains specifically binding to a certain MHC peptide complex, the domains separated by linker amino acid sequences, thereby providing each domain with the capability to bind a separate MHC peptide complex, to a nucleic acid encoding for such a polypeptide, to a vector comprising such a nucleic acid, to a host cell for expression of such a polypeptide, to a pharmaceutical composition comprising such a polypeptide, and to a kit of parts comprising at least two polypeptides according to the disclosure.
    Type: Application
    Filed: December 22, 2011
    Publication date: May 1, 2014
    Inventor: Maria Johanna J.E. Van Driel