Patents by Inventor Maria L. Garcia

Maria L. Garcia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indole diterpene alkaloid compounds
    Patent number: 5541208
    Abstract: The present invention relates to compounds of the formula: ##STR1## and the pharmaceutically acceptable salts thereof which are useful as potassium channel antagonists, particularly Maxi-K channel antagonists, and thus useful in treating Alzheimer's Disease and other cognitive disorders. This invention is also related to a method of making the compound of formula (I).
    Type: Grant
    Filed: January 24, 1994
    Date of Patent: July 30, 1996
    Assignee: Merck & Co., Inc.
    Inventors: Maria L. Garcia, Robert A. Giacobbe, Otto D. Hensens, Seok H. Lee, Owen B. McManus, Deborah L. Zink
  • Scorpion peptide margatoxin with immunosuppressant activity
    Patent number: 5494895
    Abstract: A thirty-nine amino acid peptide, Margatoxin (MgTX), is purified to homogeneity from venom of the scorpion Centruroides margaritatus. The gene encoding MgTX is constructed and this gene is expressed in E. coli, to produce recombinant MgTX. MgTX is a potent and selective inhibitor of a voltage-dependent K.sup.+ channel present in human lymphocytes. MgTX exhibits immunosuppressant activity with human T-lymphocytes, and is useful as an immunosuppressant, in modeling nonpeptidyl K.sup.+ channel blockers, and in establishing biochemical assays based on ligand binding or other protocols with which to screen for other novel modulators of voltage dependent K.sup.+ channels in lymphocytes and other tissues including the brain. As an immunosuppressant, MgTX is useful in the treatment of autoimmune diseases, the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.
    Type: Grant
    Filed: July 22, 1993
    Date of Patent: February 27, 1996
    Assignee: Merck & Co., Inc.
    Inventors: Maria L. Garcia, Gloria C. Koo, Reid J. Leonard, Chiu-Chuan S. Lin, Robert S. Slaughter, Scott P. Stevens, Joanne M. Williamson
  • Biologically active compounds
    Patent number: 5399587
    Abstract: The present invention relates to novel potassium channel agonists which are useful in activating the calcium activated Maxi-K potassium channel in mammalian neuronal and smooth muscle tissue. The claimed compounds are of the general formula: ##STR1## In addition, a novel microbiological process for producing the claimed compounds is described.
    Type: Grant
    Filed: December 13, 1993
    Date of Patent: March 21, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Maria L. Garcia, Robert A. Giacobbe, Otto D. Hensens, Gregory J. Kaczorowski, Seok H. Lee, Owen B. McManus, Deborah L. Zink
  • Anaerobic sealant unaffected by water contamination
    Patent number: 4632945
    Abstract: An anaerobic sealant material comprises an acrylate or methacrylate monomer, a hydroperoxide or pereseter initiator, an accelerator having --SO.sub.2 NHCO-functionality, and a transition metal co-accelerator gives substantially reduced moisture sensitivity if the transition metal co-accelerator is a combination of a copper salt or complex at the level of 0.5-10 ppm copper and an iron complex or salt at the level of 0.5-60 ppm iron.
    Type: Grant
    Filed: May 31, 1985
    Date of Patent: December 30, 1986
    Assignee: Loctite Corporation
    Inventors: Maria L. Garcia, Bernard M. Malofsky