Patents by Inventor Maria L. Gennaro

Maria L. Gennaro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF DIAGNOSING, PROGNOSING, AND TREATING MULTISYSTEM INFLAMMATORY SYNDROME IN CHILDREN (MIS-C) AND SEVERE COVID-19, AND APPARATUSES THEREOF
    Publication number: 20240345075
    Abstract: Embodiments disclosed here are directed to novel methods for diagnosing MIS-C or severe acute COVID-19, by detecting a biomarker in a blood sample from a subject suspected of or suffering from MIS-C or severe acute COVID-19, where the methods are for early detection or diagnosis of MIS-C or severe acute COVID-19. Also, disclosed are embodiments directed to apparatuses for use with the novel methods described here. Methods of detecting at least one biomarker and/or diagnosing MIS-C or severe acute COVID-19 disease in a pediatric subject suspected from suffering MIS-C or severe acute COVID-19 that can be used in combination with methods of treating a subject suspected of or suffering from MIS-C or severe acute COVID-19, accelerates the diagnosis and treatment, and improves prognosis.
    Type: Application
    Filed: March 15, 2024
    Publication date: October 17, 2024
    Inventors: Maria L. Gennaro, Jeisac Guzmán Rivera, Dirk Foster Moore
  • Rapid assays for T-cell activation by RNA measurements using flow cytometry
    Patent number: 11767551
    Abstract: The present invention relates to a method for rapidly detecting copies of at least one RNA molecule expressed in individual cells and uses thereof.
    Type: Grant
    Filed: January 8, 2021
    Date of Patent: September 26, 2023
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Yuri Bushkin, Maria L. Gennaro, Sanjay Tyagi, Richard Pine
  • Rapid Assays for T-Cell Activation by RNA Measurements Using Flow Cytometry
    Publication number: 20210139965
    Abstract: The present invention relates to a method for rapidly detecting copies of at least one RNA molecule expressed in individual cells and uses thereof.
    Type: Application
    Filed: January 8, 2021
    Publication date: May 13, 2021
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Yuri Bushkin, Maria L. Gennaro, Sanjay Tyagi, Richard Pine
  • Rapid assays for T-cell activation by RNA measurements using flow cytometry
    Patent number: 10900072
    Abstract: The present invention relates to a method for rapidly detecting copies of at least one RNA molecule expressed in individual cells and uses thereof.
    Type: Grant
    Filed: June 26, 2013
    Date of Patent: January 26, 2021
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Yuri Bushkin, Maria L. Gennaro, Sanjay Tyagi, Richard Pine
  • Proteins expressed by and not by BCG and their use as diagnostic reagents and vaccines
    Patent number: 9844604
    Abstract: The present invention is directed to reagents useful for generating immune responses to Mycobacterium tuberculosis and for diagnosing infection and disease in a subject that has been exposed to M. tuberculosis.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: December 19, 2017
    Assignee: Rutgers, The State University of New Jersey
    Inventor: Maria L. Gennaro
  • Proteins expressed by mycobacterium tuberculosis and not by BCG and their use as diagnostic reagents and vaccines
    Patent number: 9482671
    Abstract: The present invention is directed to reagents useful for generating immune responses to Mycobacterium tuberculosis and for diagnosing infection and disease in a subject that has been exposed to M. tuberculosis.
    Type: Grant
    Filed: January 6, 2016
    Date of Patent: November 1, 2016
    Assignee: Rutgers, The State University of New Jersey
    Inventor: Maria L. Gennaro
  • Rapid Assays for T-Cell Activation by RNA Measurements Using Flow Cytometry
    Publication number: 20160201122
    Abstract: The present invention relates to a method for rapidly detecting copies of at least one RNA molecule expressed in individual cells and uses thereof.
    Type: Application
    Filed: June 26, 2013
    Publication date: July 14, 2016
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Yuri Bushkin, Maria L. Gennaro, Sanjay Tyagi, Richard Pine
  • PROTEINS EXPRESSED BY MYCOBACTERIUM TUBERCULOSIS AND NOT BY BCG AND THEIR USE AS DIAGNOSTIC REAGENTS AND VACCINES
    Publication number: 20160169888
    Abstract: The present invention is directed to reagents useful for generating immune responses to Mycobacterium tuberculosis and for diagnosing infection and disease in a subject that has been exposed to M. tuberculosis.
    Type: Application
    Filed: February 9, 2016
    Publication date: June 16, 2016
    Applicant: Rutgers, The State University of New Jersey
    Inventor: Maria L. Gennaro
  • Proteins expressed by mycobacterium tuberculosis and not by BCG and their use as diagnostic reagents and vaccines
    Patent number: 9238066
    Abstract: The present invention is directed to reagents useful for generating immune responses to Mycobacterium tuberculosis and for diagnosing infection and disease in a subject that has been exposed to M. tuberculosis.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: January 19, 2016
    Assignee: Rutgers, The State University of New Jersey
    Inventor: Maria L. Gennaro
  • PROTEINS EXPRESSED BY MYCOBACTERIUM TUBERCULOSIS AND NOT BY BCG AND THEIR USE AS DIAGNOSTIC REAGENTS AND VACCINES
    Publication number: 20140220600
    Abstract: The present invention is directed to reagents useful for generating immune responses to Mycobacterium tuberculosis and for diagnosing infection and disease in a subject that has been exposed to M. tuberculosis.
    Type: Application
    Filed: March 7, 2014
    Publication date: August 7, 2014
    Applicant: Rutgers, The State University of New Jersey
    Inventor: Maria L. Gennaro
  • Proteins expressed by and not by BCG and their use as diagnostic reagents
    Patent number: 8623609
    Abstract: The present invention is directed to proteins expressed by Mycobacterium tuberculosis and not by BCG and their use as diagnostic reagents.
    Type: Grant
    Filed: June 21, 2011
    Date of Patent: January 7, 2014
    Assignee: Rutgers, The State University of New Jersey
    Inventor: Maria L. Gennaro
  • Proteins Expressed by Mycobacterium Tuberculosis and not by BCG and Their Use as Diagnostic Reagents
    Publication number: 20130149719
    Abstract: The present invention is directed to proteins expressed by Mycobacterium tuberculosis and not by BCG and their use as diagnostic reagents.
    Type: Application
    Filed: June 21, 2011
    Publication date: June 13, 2013
    Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
    Inventor: Maria L. Gennaro
  • PROTEINS EXPRESSED BY MYCOBACTERIUM TUBERCULOSIS AND NOT BY BCG AND THEIR USE AS VACCINES
    Publication number: 20110052637
    Abstract: The present invention is directed to proteins expressed by Mycobacterium tuberculosis and not by BCG and their use as vaccines.
    Type: Application
    Filed: May 4, 2010
    Publication date: March 3, 2011
    Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
    Inventor: Maria L. Gennaro
  • Mycobacterium tuberculosis specific proteins and genes, mixtures of antigens and uses thereof
    Patent number: 6596281
    Abstract: Two genes for proteins of M. tuberculosis have been sequenced. The DNAs and their encoded polypeptides can be used for immunoassays and vaccines. Cocktails of at least three purified recombinant antigens, and cocktails of at least three DNAs encoding them can be used for improved assays and vaccines for bacterial pathogens and parasites.
    Type: Grant
    Filed: January 26, 2000
    Date of Patent: July 22, 2003
    Assignee: The Public Health Research Institute of the City of New York, Inc.
    Inventors: Maria L. Gennaro, Konstantin P. Lyashchenko, Claudia M. A. Manca
  • Mycobacterium tuberculosis specific proteins and genes, mixtures of anitgens and uses thereof
    Patent number: 6087163
    Abstract: Two genes for proteins of M. tuberculosis have been sequenced. The DNAs and their encoded polypeptides can be used for immunoassays and vaccines. Cocktails of at least three purified recombinant antigens, and cocktails of at least three DNAs encoding them can be used for improved assays and vaccines for bacterial pathogens and parasites.
    Type: Grant
    Filed: February 6, 1997
    Date of Patent: July 11, 2000
    Assignee: The Public Health Research Institute of the City of New York, Inc.
    Inventors: Maria L. Gennaro, Konstantin P. Lyashchenko, Claudia M.A. Manca