Abstract: A device for interfacing at least one filamentous structure, with real or simulated biological tissue and a system for regeneration, repair, replacement, or simulation of tendon and/or ligamentous tissue. The device comprises one or more bodies for anchoring a filamentous structure. The one or more bodies may include at least one capstan for wrapping the filamentous structure, and at least one porous portion having a trabecular structure. The system comprises the device and at least one filamentous structure having a plurality of nanofiber assemblies that are obtained by electrospinning. The plurality of assemblies may be arranged to form a single bundle, with the bundle being wrapped to the capstan.

Abstract: The present invention relates to a process for the preparation of a porous hierarchical scaffold characterized by internal pores organized according to a hierarchical structure, for the regeneration, replacement and/or simulation of a bone tissue, in particular of the trabecular and/or cortical bone tissue. The present invention further relates to the porous hierarchical scaffold obtainable by such process and to the uses thereof. The invention further relates to the use of a sacrificial hierarchical scaffold for the preparation of such porous hierarchical scaffold.

Abstract: The present invention relates to electro spun fibers for a local release in the central nervous system of an anti-inflammatory and a promyelinating agent over a defined time-window, in order to limit secondary neurodegeneration triggered by the glutamate release and supported by on-going inflammation. The combined treatment aimed to reduce inflammation and improve remyelination in the very early stage of the pathology improving the chronic clinical outcome of the lesion. In particular the present invention relates to electrospunpolymeric fibers, wherein said fibers are loaded with 3,3,5-Triiodo-L-thyronine (T3) and Ibuprofen.

Abstract: The present invention relates to a support or a multiscale hierarchical scaffold for the tissue regeneration, in particular for the regeneration or replacement of the tendinous and/or ligamentous and/or muscular and/or nervous tissue. The present invention further relates to the processes for obtaining such support and the uses thereof.

Abstract: The present invention pertains to a process for manufacturing one or more fluoropolymer fibers, said process comprising the following steps: (i) providing a liquid composition [composition (C1)] comprising: —at least one fluoropolymer comprising at least one hydroxyl end group [polymer (FOH)L and —a liquid medium comprising at least one organic solvent [solvent (S)]; (ii) contacting the composition (C1) provided in step (i) with at least one metal compound [compound (M)] of formula (I) here below: X4?mAYm (I) wherein X is a hydrocarbon group, optionally comprising one or more functional groups, m is an integer from 1 to 4, A is a metal selected from the group consisting of Si, Ti and Zr, and Y is a hydrolysable group selected from the group consisting of an alkoxy group, an acyloxy group and a hydroxyl group, thereby providing a liquid composition [composition (C2)]; (iii) submitting to at least partial hydrolysis and/or polycondensation the composition (C2) provided in step (ii) thereby providing a liquid co

Abstract: The present invention pertains to a process for manufacturing one or more fluoropolymer fibres, said process comprising the following steps: (i) providing a liquid composition [composition (C1)] comprising: —at least one fluoropolymer comprising at least one hydroxyl end group [polymer (FOH)L and—a liquid medium comprising at least one organic solvent [solvent (S)]; (ii) contacting the composition (C1) provided in step (i) with at least one metal compound [compound (M)] of formula (I) here below: X4-mAYm (I) wherein X is a hydrocarbon group, optionally comprising one or more functional groups, m is an integer from 1 to 4, A is a metal selected from the group consisting of Si, Ti and Zr, and Y is a hydrolysable group selected from the group consisting of an alkoxy group, an acyloxy group and a hydroxyl group, thereby providing a liquid composition [composition (C2)]; (iii) submitting to at least partial hydrolysis and/or polycondensation the composition (C2) provided in step (ii) thereby providing a liquid com

Abstract: A substrate of polymeric material for wound care contains at least one oleous antimicrobial and/or helping tissue regeneration substance that is selected from Hyperforin, Adhyperforin, 1-3 Diapigenin, 11-8 Diapigenin, Rutin, Quercetin, Hypericin, Azadirachtin ?-?, Nimbin, Nimbidin, Salanin, Gallic Acid, Gedunin and combinations thereof.

Abstract: The present invention relates to a process for producing polyhydroxyalkanoate oligomers and/or polymers of reduced molecular weight, which comprises reacting at least one polyhydroxyalkanoate (PHA) with at least one carbonate salt at a temperature of from 50° C. to 300° C., preferably from 120° C. to 200° C. The above reaction allows a controlled degradation of the PHA chains which yields oligomers and/or polymers having a controlled molecular weight, which can be modulated in view of the specific application for which the oligomers and/or polymers are intended. Moreover, during the reaction carbon dioxide evolves which produces a foamed material which can be easily processed on an industrial scale.