Patents by Inventor Maria Luisa LEÓN DIAZ

Maria Luisa LEÓN DIAZ has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds for the treatment of parasitic infections
    Patent number: 11453657
    Abstract: The present invention relates to novel compounds or pharmaceutically acceptable salts thereof, corresponding compositions, and methods and/or uses in therapy, for example in the treatment of parasitic infections such as malaria, in particular infection by Plasmodium falciparum.
    Type: Grant
    Filed: January 23, 2019
    Date of Patent: September 27, 2022
    Assignee: GlaxoSmithKline Intellectual Property Development Limited
    Inventors: Maria Isabel Castellote Alvaro, Maria Luisa León Diaz, Jose Ignacio Martin Hernando
  • NOVEL COMPOUNDS FOR THE TREATMENT OF PARASITIC INFECTIONS
    Publication number: 20210047299
    Abstract: The present invention relates to novel compounds or pharmaceutically acceptable salts thereof, corresponding compositions, and methods and/or uses in therapy, for example in the treatment of parasitic infections such as malaria, in particular infection by Plasmodium falciparum.
    Type: Application
    Filed: January 23, 2019
    Publication date: February 18, 2021
    Inventors: Maria Isabel CASTELLOTE ALVARO, Maria Luisa LEÓN DIAZ, Jose Ignacio MARTIN HERNANDO
  • Compound (S) and (R)-N-(2-fluoropyridin-4-yl)-3-methyl-2-(5-methyl-2,4-dioxo-1,2-dihydropyrido[3,4-d]pyrimidin-3(4H)-yl)butanamide and use
    Patent number: 9624219
    Abstract: The present invention relates to a compound of Formula (I) having pharmacological activity, processes for its preparation, pharmaceutical compositions and their use in the treatment of certain parasitic certain parasitic protozoal infections such as malaria, in particular infection by Plasmodium falciparum. (S)—N-(2-fluoropyridin-4-yl)-3-methyl-2-(5-methyl-2,4-dioxo-1,2-dihydropyrido[3,4-d]pyrimidin-3(4H)-yl)butanamide.
    Type: Grant
    Filed: April 19, 2016
    Date of Patent: April 18, 2017
    Assignee: GlaxoSmithKline Intellectual Property Development Limited
    Inventors: Jose-Miguel Coteron Lopez, Esther Pilar Fernandez Velando, Jorge Fernandez-Molina, Maria Luisa Leon-Diaz, David Matthew Wilson
  • Compound (S) and (R)-N-(2-fluoropyridin-4-yl)-3-methyl-2-(5-methyl-2,4-dioxo-1,2-dihydropyrido[3,4-d]pyrimidin-3(4H)-yl)butanamide and use
    Publication number: 20160311821
    Abstract: The present invention relates to a compound of Formula (I) having pharmacological activity, processes for its preparation, pharmaceutical compositions and their use in the treatment of certain parasitic certain parasitic protozoal infections such as malaria, in particular infection by Plasmodium falciparum. (S)-N-(2-fluoropyridin-4-yl)-3-methyl-2-(5-methyl-2,4-dioxo-1,2-dihydropyrido[3,4-d]pyrimidin-3(4H)-yl)butanamide.
    Type: Application
    Filed: April 19, 2016
    Publication date: October 27, 2016
    Inventors: Jose-Miguel COTERON LOPEZ, Esther Pilar FERNANDEZ VELANDO, Jorge FERNANDEZ-MOLINA, Maria Luisa LEON-DIAZ, David Matthew WILSON
  • (Pyrazol-3-yl)-1,3,4-thiadiazol-2-amine and (pyrazol-3-yl)-1,3,4-thiazol-2-amine compounds
    Patent number: 8524750
    Abstract: A compound of Formula (I) wherein: either X is N and Y is CR5 or X is C and Y is S; Z is selected from N and CH; R1 is selected from H and Me; R2 is selected from H, OH, OMe and Me; each R3 is independently selected from C1-3alkyl, F, Cl, Br, CF3 and NH2; R4 is selected from Me, CF3, NO2 and CHF2; R5 is selected from H, Me and CHF2; R6 is selected from H and Me; and p is 0-3, compositions containing them, their use in therapy, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided.
    Type: Grant
    Filed: April 13, 2010
    Date of Patent: September 3, 2013
    Assignee: Glaxo Group Limited
    Inventors: Lluis Ballell Pages, Julia Castro Pichel, Raquel Fernandez Menendez, Esther Pilar Fernandez Velando, Silvia Gonzalez Del Valle, Maria Luisa Leon Diaz, Alfonso Mendoza Losana, Matthew James Wolfendale
  • (PYRAZOL-3-YL)-1,3,4-THIADIAZOL-2-AMINE AND (PYRAZOL-3-YL)-1,3,4-THIAZOL-2-AMINE COMPOUNDS
    Publication number: 20120095064
    Abstract: A compound of Formula (I) wherein: either X is N and Y is CR5 or X is C and Y is S; Z is selected from N and CH; R1 is selected from H and Me; R2 is selected from H, OH, OMe and Me; each R3 is independently selected from C1-3alkyl, F, Cl, Br, CF3 and NH2; R4 is selected from Me, CF3, NO2 and CHF2; R5 is selected from H, Me and CHF2; R6 is selected from H and Me; and p is 0-3, compositions containing them, their use in therapy, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided.
    Type: Application
    Filed: April 13, 2010
    Publication date: April 19, 2012
    Inventors: Lluis Ballell Pages, Julia Castro Pichel, Raquel Fernandez Menendez, Esther Pilar Fernandez Velando, Silvia Gonzalez Del Valle, Maria Luisa Leon Diaz, Alfonso Mendoza Losana, Matthew James Wolfendale