Patents by Inventor Maria M. Mota

Maria M. Mota has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ruthenium carbon monoxide releasing molecules and uses thereof
    Patent number: 9611286
    Abstract: The present invention provides novel ruthenium compounds of Formula (I): or salts, isomers, hydrates, or solvates thereof, or combinations thereof; wherein E, R1, R2, R3, R4, R5, X1, and X2 are as defined herein, and pharmaceutical compositions thereof. Also provided are methods of use and treatment. Such compounds have been found useful in the treatment of malaria infection. Such compounds may also be useful in the treatment of inflammatory conditions, such as acute lung injury and acute resipiratory distress syndrome, which optionally may be associated with a malaria infection.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: April 4, 2017
    Assignee: Alfama, Inc.
    Inventors: Ana Pamplona, Gonçalo J. L. Bernardes, Maria M. Mota, Carlos C. Romão
  • RUTHENIUM CARBON MONOXIDE RELEASING MOLECULES AND USES THEREOF
    Publication number: 20160237105
    Abstract: The present invention provides novel ruthenium compounds of Formula (I): or salts, isomers, hydrates, or solvates thereof, or combinations thereof; wherein E, R1, R2, R3, R4, R5, X1, and X2 are as defined herein, and pharmaceutical compositions thereof. Also provided are methods of use and treatment. Such compounds have been found useful in the treatment of malaria infection. Such compounds may also be useful in the treatment of inflammatory conditions, such as acute lung injury and acute resipiratory distress syndrome, which optionally may be associated with a malaria infection.
    Type: Application
    Filed: May 13, 2015
    Publication date: August 18, 2016
    Applicant: Alfama, Inc.
    Inventors: Ana Pamplona, Gonçalo J.L. Bernardes, Maria M. Mota, Carlos C. Romão
  • RUTHENIUM CARBON MONOXIDE RELEASING MOLECULES AND USES THEREOF
    Publication number: 20150322105
    Abstract: The present invention provides novel ruthenium compounds of Formula (I): or salts, isomers, hydrates, or solvates thereof, or combinations thereof; wherein E, R1, R2, R3, R4, R5, X1, and X2 are as defined herein, and pharmaceutical compositions thereof. Also provided are methods of use and treatment. Such compounds have been found useful in the treatment of malaria infection. Such compounds may also be useful in the treatment of inflammatory conditions, such as acute lung injury and acute resipiratory distress syndrome, which optionally may be associated with a malaria infection.
    Type: Application
    Filed: May 13, 2015
    Publication date: November 12, 2015
    Applicant: Alfama, Inc.
    Inventors: Ana Pamplona, Gonçalo J.L. Bernardes, Maria M. Mota, Carlos C. Romão
  • Ruthenium carbon monoxide releasing molecules and uses thereof
    Patent number: 9062089
    Abstract: The present invention provides novel ruthenium compounds of Formula (I): or salts, isomers, hydrates, or solvates thereof, or combinations thereof; wherein E, R1, R2, R3, R4, R5, X1, and X2 are as defined herein, and pharmaceutical compositions thereof. Also provided are methods of use and treatment. Such compounds have been found useful in the treatment of malaria infection. Such compounds may also be useful in the treatment of inflammatory conditions, such as acute lung injury and acute respiratory distress syndrome, which optionally may be associated with a malaria infection.
    Type: Grant
    Filed: July 21, 2012
    Date of Patent: June 23, 2015
    Assignee: Alfama, Inc.
    Inventors: Ana Pamplona, Gonçalo J. L. Bernardes, Maria M. Mota, Carlos C. Romão
  • RUTHENIUM CARBON MONOXIDE RELEASING MOLECULES AND USES THEREOF
    Publication number: 20140219996
    Abstract: The present invention provides novel ruthenium compounds of Formula (I): or salts, isomers, hydrates, or solvates thereof, or combinations thereof; wherein E, R1, R2, R3, R4, R5, X1, and X2 are as defined herein, and pharmaceutical compositions thereof. Also provided are methods of use and treatment. Such compounds have been found useful in the treatment of malaria infection. Such compounds may also be useful in the treatment of inflammatory conditions, such as acute lung injury and acute respiratory distress syndrome, which optionally may be associated with a malaria infection.
    Type: Application
    Filed: July 20, 2012
    Publication date: August 7, 2014
    Applicant: ALFAMA- Investigacao e Desenvolvimento de Produtos Farmacêuticos, Lda.
    Inventors: Ana Pamplona, Gonçalo J.L. Bernardes, Maria M. Mota, Carlos C. Romão
  • Use of inhibitors of scavenger receptor class proteins for the treatment of infectious diseases
    Patent number: 8507546
    Abstract: The present invention relates to the use of inhibitors of scavenger receptor class proteins, in particular ScarB1 for the production of a medicament for treatment of and/or prophylaxis against infections, involving liver cells and/or hematopoietic cells, in particular malaria.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: August 13, 2013
    Assignees: Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Cenix Bioscience GmbH
    Inventors: Michael Hannus, Cecilie Martin, Maria M. Mota, Miguel Prudencio, Christina Dias Rodrigues
  • USE OF INHIBITORS OF SCAVENGER RECEPTOR CLASS PROTEINS FOR THE TREATMENT OF INFECTIOUS DISEASES
    Publication number: 20120276121
    Abstract: The present invention relates to the use of inhibitors of scavenger receptor class proteins, in particular ScarB1 for the production of a medicament for treatment of and/or prophylaxis against infections, involving liver cells and/or hematopoietic cells, in particular malaria.
    Type: Application
    Filed: July 13, 2012
    Publication date: November 1, 2012
    Applicants: INSTITUTO DE MEDICINA MOLECULAR, FACULDADE DE MEDICINA DA UNIVERSIDADE DE LISBOA, CENIX BIOSCIENCE GMBH
    Inventors: MICHAEL HANNUS, CECILIE MARTIN, MARIA M. MOTA, MIGUEL PRUDENCIO, CHRISTINA DIAS RODRIGUES
  • Method for the prevention of malaria infection of humans by hepatocyte growth factor antagonists
    Patent number: 7670631
    Abstract: A method for the prevention of infection of humans by plasmodium parasites is provided. The method consists of the application of compounds that interfere with the infection of hepatocytes by Plasmodium viax.
    Type: Grant
    Filed: March 9, 2004
    Date of Patent: March 2, 2010
    Assignee: ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda.
    Inventors: Maria M. Mota, Ana Rodriguez, Silvia Giordano, Margarida Cunha Rodrigues
  • Use of Inhibitors of Scavenger Receptor Class Proteins for the Treatment of Infectious Diseases
    Publication number: 20090324580
    Abstract: The present invention relates to the use of inhibitors of scavenger receptor class proteins, in particular ScarB1 for the production of a medicament for treatment of and/or prophylaxis against infections, involving liver cells and/or hematopoietic cells, in particular malaria.
    Type: Application
    Filed: March 9, 2007
    Publication date: December 31, 2009
    Applicants: CENIX BIOSCIENCE GMBH, INSTITUTO DE MEDICINA MOLECULAR , FACULDADE DE MEDICINA DA UNIVERSIDADA DE LISBOA
    Inventors: Michael Hannus, Cecilie Martin, Maria M. Mota, Miguel Prudencio, Christina Dias Rodrigues
  • Method for the prevention of malaria infection of humans by hepatocyte growth factor antagonists
    Publication number: 20040185050
    Abstract: A method for the prevention of infection of humans by plasmodium parasites is provided. The method consists of the application of compounds that interfere with the infection of hepatocytes by Plasmodium viax.
    Type: Application
    Filed: March 9, 2004
    Publication date: September 23, 2004
    Inventors: Maria M. Mota, Ana Rodriguez, Silvia Giordano, Margarida Cunha Rodrigues