Patents by Inventor Maria Margarita Garcia-Calvo

Maria Margarita Garcia-Calvo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NPC1L1 (NPC3) and methods of identifying ligands thereof
    Patent number: 7901893
    Abstract: The present invention provides human, rat and mouse NPCIL1 polypeptides and polynucleotides encoding the polypeptides. Methods for detecting ligands which bind to NPC1L1 and block intestinal cholesterol absorption are provided. Also included is a method of identifying ligands which bind to NPCILI using membranes derived from brush border membrane preparations. Compounds that bind to NPCILI can be used for inhibiting intestinal cholesterol absorption in a subject.
    Type: Grant
    Filed: January 14, 2005
    Date of Patent: March 8, 2011
    Assignee: Merck Sharp & Dohme Corp.
    Inventor: Maria Margarita Garcia-Calvo
  • Npcil1 (Npc3) And Methods Of Identifying Ligands Thereof
    Publication number: 20100009461
    Abstract: The present invention provides human, rat and mouse NPCIL1 polypeptides and polynucleotides encoding the polypeptides. Methods for detecting ligands which bind to NPC1L1 and block intestinal cholesterol absorption are provided. Also included is a method of identifying ligands which bind to NPCILI using membranes derived from brush border membrane preparations. Compounds that bind to NPCILI can be used for inhibiting intestinal cholesterol absorption in a subject.
    Type: Application
    Filed: January 14, 2005
    Publication date: January 14, 2010
    Inventor: Maria Margarita Garcia-Calvo