Patents by Inventor Maria Papamichelakis

Maria Papamichelakis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR THE PREPARATION OF HYDROXY-SUBSTITUTED ARYL SULFAMIDE COMPOUNDS
    Publication number: 20090156826
    Abstract: The present invention is directed to processes for the preparation of hydroxy-substituted aryl sulfamide derivatives of the formula I or pharmaceutically acceptable salts, stereoisomers or tautomers thereof, which are monoamine reuptake inhibitors wherein the constituent variables are as defined herein.
    Type: Application
    Filed: December 11, 2008
    Publication date: June 18, 2009
    Applicant: Wyeth
    Inventors: Maria Papamichelakis, Jacqueline Francesca Lunetta, Mark Lankau, Luc Richard, Christopher Kendall, Marcelo Cesar Saraiva, Xianghui Wen, Mahmoud Mirmehrabi, Valerie Paquet, Sylvain Daigneault, Puwen Zhang
  • Quinoline Intermediates of Receptor Tyrosine Kinase Inhibitors and the Synthesis Thereof
    Publication number: 20090030197
    Abstract: This invention is directed to methods of preparing 4-substituted quinoline compounds as intermediates in the manufacture of receptor tyrosine kinase inhibitors and intermediate compounds used in the methods thereof, wherein the 4-substituted quinoline compound has the following general formula (I): wherein substitutions at LG?, PG, A, G, R1 and R4 are set forth in the specification.
    Type: Application
    Filed: August 28, 2008
    Publication date: January 29, 2009
    Applicant: WYETH
    Inventors: Warren Chew, Maria Papamichelakis, Youchu Wang
  • Quinoline intermediates of receptor tyrosine kinase inhibitors and the synthesis thereof
    Patent number: 7432377
    Abstract: This invention is directed to methods of preparing 4-substituted quinoline compounds as intermediates in the manufacture of receptor tyrosine kinase inhibitors and intermediate compounds used in the methods thereof, wherein the 4-substituted quinoline compound has the following general formula (I): wherein substitutions at LG?, PG, A, G, R1 and R4 are set forth in the specification.
    Type: Grant
    Filed: January 14, 2005
    Date of Patent: October 7, 2008
    Assignee: Wyeth
    Inventors: Warren Chew, Maria Papamichelakis, Youchu Wang
  • Process for the Synthesis of Monosulfated Derivatives of Substituted Benzoxazoles
    Publication number: 20080139820
    Abstract: The present invention provides synthetic processes for the preparation of mono-sulfated derivatives of substituted benzoxazoles, which are useful as estrogenic agents.
    Type: Application
    Filed: November 29, 2007
    Publication date: June 12, 2008
    Applicant: WYETH
    Inventors: Youchu WANG, Silvio IERA, Maria PAPAMICHELAKIS
  • Process for the Synthesis of Monosulfated Derivatives of Substituted Benzoxazoles
    Publication number: 20080139819
    Abstract: The present invention provides synthetic processes for the preparation of mono-sulfated derivatives of substituted benzoxazoles, which are useful as estrogenic agents.
    Type: Application
    Filed: November 29, 2007
    Publication date: June 12, 2008
    Applicant: WYETH
    Inventors: Youchu WANG, Silvio IERA, Maria PAPAMICHELAKIS
  • Method of preparing 3-cyano-quinolines and intermediates made thereby
    Publication number: 20060270669
    Abstract: The present invention relates to methods for preparing substituted 3-cyanoquinolines and intermediates obtained by the methods of the present invention. The methods of the invention comprise reacting an N-aryl-2-propanimide with phosphoryl chloride to produce the substituted 3-cyanoquinolines. The methods further comprise reacting arylamines, orthoformates and active methylenes to produce the N-aryl-2-propenamide.
    Type: Application
    Filed: May 25, 2006
    Publication date: November 30, 2006
    Inventors: Warren Chew, Maria Papamichelakis
  • Preparation and purification of antiviral disulfonic acid disodium salt
    Patent number: 6960686
    Abstract: The present invention provides a new process and intermediates for the production of antiviral compound 4?,4-bis-{4,6-bis-[3-(bis-carbamoyl-methyl-1-sulfamoyl)-phenylamino]-[1,3,5]triazin-2-ylamino}-biphenyl-2,2?-disulfonic acid and its pharmaceutically acceptable salts.
    Type: Grant
    Filed: September 22, 2004
    Date of Patent: November 1, 2005
    Assignee: Wyeth
    Inventors: Silvio Iera, Christopher A. Demerson, Jacqueline F. Lunetta, Maria Papamichelakis, Michael F. MacEwan, Wayne G. McMahon, John R. Potoski, Arthur G. Mohan, Antonia Nikitenko
  • Quinoline intermediates of receptor tyrosine kinase inhibitors and the synthesis thereof
    Publication number: 20050159446
    Abstract: This invention is directed to methods of preparing 4-substituted quinoline compounds as intermediates in the manufacture of receptor tyrosine kinase inhibitors and intermediate compounds used in the methods thereof, wherein the 4-substituted quinoline compound has the following general formula (I): wherein substitutions at LG?, PG, A, G, R1 and R4 are set forth in the specification.
    Type: Application
    Filed: January 14, 2005
    Publication date: July 21, 2005
    Inventors: Warren Chew, Maria Papamichelakis, Youchu Wang
  • Preparation and purification of antiviral disulfonic acid disodium salt
    Publication number: 20050038026
    Abstract: The present invention provides a new process and intermediates for the production of antiviral compound 4?,4-bis-{4,6-bis-[3-(bis-carbamoyl-methyl-1-sulfamoyl)-phenylamino]-[1,3,5]triazin-2-ylamino}-biphenyl-2,2?-disulfonic acid and its pharmaceutically acceptable salts.
    Type: Application
    Filed: September 22, 2004
    Publication date: February 17, 2005
    Applicant: WYETH
    Inventors: Silvio Iera, Christopher Demerson, Jacqueline Lunetta, Maria Papamichelakis, Michael MacEwan, Wayne McMahon, John Potoski, Arthur Mohan
  • Preparation and purification of antiviral disulfonic acid disodium salt
    Patent number: 6806366
    Abstract: The present invention provides a new process and intermediates for the production of antiviral compound 4′,4-bis-{4,6-bis-[3-(bis-carbamoyl-methyl-1-sulfamoyl)-phenylamino]-[1,3,5]triazin-2-ylamino}-biphenyl-2,2′-disulfonic acid and its pharmaceutically acceptable salts.
    Type: Grant
    Filed: January 31, 2002
    Date of Patent: October 19, 2004
    Assignee: Wyeth
    Inventors: Silvio Iera, Christopher A. Demerson, Jacqueline F. Lunetta, Maria Papamichelakis, Michael F. MacEwan, Wayne G. McMahon, John R. Potoski, Arthur G. Mohan
  • Preparation and purification of antiviral disulfonic acid disodium salt
    Publication number: 20020151548
    Abstract: The present invention provides a new process and intermediates for the production of antiviral compound 4′,4-bis-{4,6-bis-[3-(bis-carbamoyl-methyl-1-sulfamoyl)-phenylamino]-[1,3,5]triazin-2-ylamino}-biphenyl-2,2′-disulfonic acid and its pharmaceutically acceptable salts.
    Type: Application
    Filed: January 31, 2002
    Publication date: October 17, 2002
    Applicant: American Home Products Corporation
    Inventors: Silvio Iera, Christopher A. Demerson, Jacqueline F. Lunetta, Maria Papamichelakis, Michael F. MacEwan, Wayne G. McMahon, John R. Potoski, Arthur G. Mohan