Patents by Inventor Maria Petrus Leonardus Van Lent

Maria Petrus Leonardus Van Lent has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Expression of dc-sign by macrophages and methods of treating and diagnosing rheumatoid arthritis
    Publication number: 20060121033
    Abstract: The C-type lectin DC-SIGN is absent in normal synovium but is highly expressed by CD68 positive macrophages in the synovium of rheumatoid arthritis patients. Accordingly, rheumatoid arthritis is diagnosed or treated by, respectively, assaying or blocking DC-SIGN. This can be accomplished by the use of agents, e.g., antibodies, which bind specifically to DCSIGN. Agents that bind to ICAM-3 are used to block inhibition of activation of macrophages by DC-SIGN-ICAM-3 interaction and cause inhibition of rheumatoid arthritis symptoms.
    Type: Application
    Filed: September 19, 2003
    Publication date: June 8, 2006
    Inventors: Carl Figdor, Ruurd Torensma, Maria Petrus Leonardus Van Lent, Wim Van Den Berg