Patents by Inventor Maria Rosario Gonzalez-Garcia

Maria Rosario Gonzalez-Garcia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9073856
    Abstract: The present invention provides compounds of Formula I or a pharmaceutical salt thereof, where the variables for R1, R2, and R3 are as described herein; methods of treating a condition such as hypertriglyceridemia; and processes for preparing the compounds.
    Type: Grant
    Filed: January 16, 2013
    Date of Patent: July 7, 2015
    Assignee: Eli Lilly and Company
    Inventors: Maria Carmen Fernandez, Maria Rosario Gonzalez-Garcia, Bin Liu, Lance Allen Pfeifer
  • Patent number: 8993568
    Abstract: The present invention provides compounds of Formula I or a pharmaceutical salt thereof, methods of treating hypertriglyceridemia using the compounds; and a process for preparing the compounds.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: March 31, 2015
    Assignee: Eli Lilly and Company
    Inventors: Maria Rosario Gonzalez-Garcia, Maria Carmen Fernandez
  • Publication number: 20150005305
    Abstract: The present invention provides compounds of Formula I or a pharmaceutical salt thereof, methods of treating hypertriglyceridemia using the compounds; and a process for preparing the compounds.
    Type: Application
    Filed: January 24, 2013
    Publication date: January 1, 2015
    Applicant: Eli Lilly and Company
    Inventors: Maria Rosario Gonzalez-Garcia, Maria Carmen Fernnandez
  • Publication number: 20140371269
    Abstract: The present invention provides compounds of Formula I or a pharmaceutical salt thereof, where the variables for R1, R2, and R3 are as described herein; methods of treating a condition such as hypertriglyceridemia; and processes for preparing the compounds.
    Type: Application
    Filed: January 16, 2013
    Publication date: December 18, 2014
    Applicant: Eli Lilly and Company
    Inventors: Maria Carmen Fernandez, Maria Rosario Gonzalez-Garcia, Bin Liu, Lance Allen Pfeifer
  • Patent number: 8575352
    Abstract: The present invention provides compounds of Formula below: and analogues thereof where the various substituent groups, R1, R2, R3, R4, R5 A, and X are described herein; or a pharmaceutical salt thereof; a method of treating a condition such as hypertriglyceridemia and a process for preparing the compounds.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: November 5, 2013
    Assignee: Eli Lilly and Company
    Inventors: Maria Carmen Fernandez, Lance Allen Pfeifer, Maria Rosario Gonzalez-Garcia
  • Patent number: 7745438
    Abstract: The present invention provides BACE inhibitors of Formula (I); methods for their use and preparation, and intermediates useful for their preparation.
    Type: Grant
    Filed: September 20, 2005
    Date of Patent: June 29, 2010
    Assignee: Eli Lilly and Company
    Inventors: Howard Barff Broughton, Robert Dean Dally, Timothy Barrett Durham, Maria Rosario Gonzalez-Garcia, Patric James Hahn, Kenneth James Henry, Jr., Todd Jonathan Kohn, James Ray McCarthy, Timothy Alan Shepherd, Jon Andre Erickson, Ana Belen Bueno Melendo
  • Patent number: 7618978
    Abstract: The present invention provides BACE inhibitors of Formula (I): methods for their use, and intermediates and methods for their preparation.
    Type: Grant
    Filed: April 8, 2005
    Date of Patent: November 17, 2009
    Assignee: Eli Lilly and Company
    Inventors: Ana Belen Bueno Melendo, Shu-Hui Chen, Maria Rosario Gonzalez-Garcia, James Ray McCarthy
  • Publication number: 20080167310
    Abstract: The present invention is directed to a compound of formula I, and pharmaceutically acceptable salts, solvates, hydrates or stereoisomer thereof, which are useful in treating Syndrome X, Type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, arteriosclerosis, and other disorders related to Syndrome X as well as cardiovascular diseases.
    Type: Application
    Filed: October 3, 2007
    Publication date: July 10, 2008
    Inventors: Lynn Stacy Gossett, Jonathan Edward Green, James Robert Henry, Winton Dennis Jones, Donald Paul Matthews, Quanrong Shen, Daryl Lynn Smith, Jennifer Ann Vance, Alan M. Warshawsky, Maria Rosario Gonzalez-Garcia
  • Publication number: 20070225267
    Abstract: The present invention provides BACE inhibitors of Formula (I); methods for their use and preparation, and intermediates useful for their preparation.
    Type: Application
    Filed: September 20, 2005
    Publication date: September 27, 2007
    Inventors: Howard Broughton, Robert Dally, Timothy Durham, Maria Rosario Gonzalez-Garcia, Lilly Sa, Patric Hahn, Kenneth Henry, Todd Kohn, James McCarthy, Timothy Shepherd, Jon Erickson, Ana Bueno Melendo
  • Publication number: 20070225372
    Abstract: The present invention provides BRACE inhibitors of Formula (I): methods for their use, and intermediates and methods for their preparation.
    Type: Application
    Filed: April 8, 2005
    Publication date: September 27, 2007
    Inventors: Ana Bueno Melendo, Shu-Hui Chen, Jon Erickson, Maria Rosario Gonzalez-Garcia, Deqi Guo, Alicia Marcos Lorente, James McCarthy, Timothy Shepherd, Scott Sheehan, Yvonne Yip
  • Patent number: 7081481
    Abstract: Compounds of the formula (I) in which: R1 is (CH2)nY; n is 1 or 2; Y is NHSO2R2 or X1—W—X2—R3; X1 is O or NH; W is C?O, C?S, C?NH, or SO2; X2 is O or NH, provided that X1 and X2 are not both O; R2 is C1-10 alkyl; C2-10 alkenyl; C2-10 alkynyl; aryl; aryl-C1-10 alkyl; aryl-C2-10 alkenyl; aryl-C2-10alkynyl; C3-8 cycloalkyl or C3-8-cycloalkyl-C1-10 alkyl; and R3 is hydrogen, C1-10alkyl; C2-10 alkenyl; C2-10 alkynyl; aryl; aryl-C1-10 alkyl; aryl-C2-10 alkenyl; aryl-C2-10 alkynyl; C3-8 cycloalkyl; or C3-8-cycloalkyl-C1-10 alkyl; or a salt or ester thereof, modulate metabotropic glutamate receptor function and are useful in treating disorders of the central nervous system.
    Type: Grant
    Filed: May 24, 2001
    Date of Patent: July 25, 2006
    Assignee: Eli Lilly and Company
    Inventors: Ivan Collado-Cano, Maria Rosario Gonzalez-Garcia, Beatriz López De Uralde-Garmendia
  • Publication number: 20040102521
    Abstract: Compounds of the formula (I) in which: R1 is (CH2)nY; n is 1 or 2; Y is NHSO2R2 or X1—W—X2—R3; X1 is O or NH; W is C═O, C═S, C═NH, or SO2; X2 is O or NH, provided that X1 and X2 are not both O; R2 is C1-10 alkyl; C2-10 alkenyl; C2-10 alkynyl; aryl; aryl-C1-10 alkyl; aryl-C2-10 alkenyl; aryl-C2-10alkynyl; C3-8 cycloalkyl or C3-8-cycloalkyl-C1-10 alkyl; and R3 is hydrogen, C1-10alkyl; C2-10 alkenyl; C2-10 alkynyl; aryl; aryl-C1-10 alkyl; aryl-C2-10 alkenyl; aryl-C2-10 alkynyl; C3-8 cycloalkyl; or C3-8-cycloalkyl-C1-10 alkyl; or a salt or ester thereof, modulate metabotropic glutamate receptor function and are useful in treating disorders of the central nervous system.
    Type: Application
    Filed: June 20, 2003
    Publication date: May 27, 2004
    Inventors: Ivan Collado-Cano, Maria Rosario Gonzalez-Garcia, Beatriz Lopez De Uraldegarmendia
  • Patent number: 6498180
    Abstract: Compounds of formula (I) in which R1 is halo-C1-10 alkyl; halo-C2-10 alkenyl; or (CH2)nY in which n is 1 or 2 and Y is OH, CN, N3, OR3, SH, S(O)pR4, S(O)3H, NH2, NHR5, NR6R7, NHCOR8, NO2, CO2H, CONHR9, 1H-tetrazol-5-yl, 5-phenyltetrazol-2-yl or PO3H2; R3, R5, R6, R7, R8 and R9 are each selected independently from C1-4 alkyl, aryl and aryl-C1-4 alkyl; R4 is selected from C1-4 alkyl, aryl, aryl-C1-4 alkyl, and 1H-tetrazol-5-yl, carboxy-(1-4C)alkyl and 1H-tetrazol-5-yl-C1-4 alkyl; and p is 0, 1, 2 or 3; or a salt or ester thereof, provided that R1 is not methoxymethyl, modulate metabotropic glutamate receptor function and are useful in treating disorders of the central nervous system.
    Type: Grant
    Filed: November 16, 2001
    Date of Patent: December 24, 2002
    Assignee: Eli Lilly and Company
    Inventors: Ivan Collado Cano, Concepcion Pedregal Tercero, Alicia Marcos Llorente, Beatriz Lopez de Uralde Garmendia, Maria Rosario Gonzalez Garcia, Ana Belen Bueno Melendo