Patents by Inventor Maria X. H. Yang

Maria X. H. Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mitogen-activated protein kinase p38-2 and methods of use therefor
    Patent number: 7202049
    Abstract: Compositions and methods are provided for the treatment of diseases associated with mitogen activated protein kinase cascades. In particular, the mitogen-activated protein kinase p38-2, and polypeptide variants thereof that stimulate phosphorylation and activation of substrates such as ATF2, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit or activate signal transduction via the p38-2 kinase cascade. Such polypeptides and agents may also be used for the treatment of diseases associated with mitogen-activated protein kinase cascades.
    Type: Grant
    Filed: July 16, 2002
    Date of Patent: April 10, 2007
    Assignee: Signal Pharmaceuticals, Inc.
    Inventors: Bernd Stein, Maria X. H. Yang, David B. Young
  • Mitogen-activated protein kinase kinase MEK6 and methods of use thereof
    Publication number: 20040235112
    Abstract: Compositions and methods are provided for potentiating the activity of the mitogen-activated protein kinase p38. In particular the mitogen-activated protein kinase kinase MEK6, and variants thereof that stimulate phosphorylation of p38 are provided. Such compounds may be used, for example, for therapy of diseases associated with the p38 cascade and to identify antibodies and other agents that inhibit or activate signal transduction via p38.
    Type: Application
    Filed: June 16, 2004
    Publication date: November 25, 2004
    Applicant: Signal Pharmaceuticals, Inc.
    Inventors: Bernd Stein, Maria X. H. Yang
  • Mitogen-activated protein kinase p38-2 and methods of use therefor
    Patent number: 6677130
    Abstract: Compositions and methods are provided for the treatment of diseases associated with mitogen activated protein kinase cascades. In particular, the mitogen-activated protein kinase p38-2, and polypeptide variants thereof that stimulate phosphorylation and activation of substrates such as ATF2, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit or activate signal transduction via the p38-2 kinase cascade. Such polypeptides and agents may also be used for the treatment of diseases associated with mitogen-activated protein kinase cascades.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: January 13, 2004
    Assignee: Signal Pharmaceuticals, Inc.
    Inventors: Bernd Stein, Maria X. H. Yang, David B. Young
  • Mitogen-activated protein kinase MEK6 and methods of use therefor
    Publication number: 20030175928
    Abstract: Compositions and methods are provided for potentiating the activity of the mitogen-activated protein kinase p38. In particular the mitogen-activated protein kinase kinase MEK6, and variants thereof that stimulate phosphorylation of p38 are provided. Such compounds may be used, for example, for therapy of diseases associated with the p38 cascade and to identify antibodies and other agents that inhibit or activate signal transduction via p38.
    Type: Application
    Filed: April 2, 2003
    Publication date: September 18, 2003
    Applicant: Signal Pharmaceuticals, Inc.
    Inventors: Bernd Stein, Maria X. H. Yang
  • Mitogen-activated protein kinase p38-2 and methods of use therefor
    Publication number: 20030059881
    Abstract: Compositions and methods are provided for the treatment of diseases associated with mitogen activated protein kinase cascades. In particular, the mitogen-activated protein kinase p38-2, and polypeptide variants thereof that stimulate phosphorylation and activation of substrates such as ATF2, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit or activate signal transduction via the p38-2 kinase cascade. Such polypeptides and agents may also be used for the treatment of diseases associated with mitogen-activated protein kinase cascades.
    Type: Application
    Filed: July 16, 2002
    Publication date: March 27, 2003
    Applicant: Signal Pharmaceuticals, Inc.
    Inventors: Bernd Stein, Maria X.H. Yang, David B. Young
  • Mitogen-activated protein kinase p38-2 and methods of use therefor
    Publication number: 20030054528
    Abstract: Compositions and methods are provided for the treatment of diseases associated with mitogen activated protein kinase cascades. In particular, the mitogen-activated protein kinase p38-2, and polypeptide variants thereof that stimulate phosphorylation and activation of substrates such as ATF2, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit or activate signal transduction via the p38-2 kinase cascade. Such polypeptides and agents may also be used for the treatment of diseases associated with mitogen-activated protein kinase cascades.
    Type: Application
    Filed: July 18, 2002
    Publication date: March 20, 2003
    Applicant: Signal Pharmaceuticals, Inc.
    Inventors: Bernd Stein, Maria X. H. Yang, David B. Young
  • Mitogen-activated protein kinase P38-2 and methods of use therefor
    Patent number: 6444455
    Abstract: Compositions and methods are provided for the treatment of diseases associated with mitogen activated protein kinase cascades. In particular, the mitogen-activated protein kinase p38-2, and polypeptide variants thereof that stimulate phosphorylation and activation of substrates such as ATF2, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit or activate signal transduction via the p38-2 kinase cascade. Such polypeptides and agents may also be used for the treatment of diseases associated with mitogen-activated protein kinase cascades.
    Type: Grant
    Filed: April 20, 1999
    Date of Patent: September 3, 2002
    Assignee: Signal Pharmaceuticals, Inc.
    Inventors: Bernd Stein, Maria X. H. Yang, David B. Young
  • Mitogen-activated protein kinase kinase MEK6 and variants thereof
    Patent number: 6074862
    Abstract: Compositions and methods are provide for potentiating the activity of the mitogen-activated protein kinase p38. In particular the mitogen-activated protein kinase kinase MEK6, and variants thereof that stimulate phosphorylation of p38 are provided. Such compounds may be used, for example, for therapy of diseases associated with the p38 cascade and to identify antibodies and other agents that inhibit or activate signal transduction via p38.
    Type: Grant
    Filed: December 20, 1995
    Date of Patent: June 13, 2000
    Assignee: Signal Pharmaceuticals Inc.
    Inventors: Bernd Stein, Maria X. H. Yang
  • Mitogen-activated protein kinase p38-2 and methods of use therefor
    Patent number: 5948885
    Abstract: Compositions and methods are provided for the treatment of diseases associated with mitogen activated protein kinase cascades. In particular, the mitogen-activated protein kinase p38-2, and polypeptide variants thereof that stimulate phosphorylation and activation of substrates such as ATF2, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit or activate signal transduction via the p38-2 kinase cascade. Such polypeptides and agents may also be used for the treatment of diseases associated with mitogen-activated protein kinase cascades.
    Type: Grant
    Filed: May 20, 1996
    Date of Patent: September 7, 1999
    Assignee: Signal Pharmaceuticals, Inc.
    Inventors: Bernd Stein, Maria X. H. Yang, David B. Young