Abstract: A risk-prediction-preparation module to generate a risk-prediction-model, is provided herein. The risk-prediction-preparation module includes accessing a data-storage of transactions to operate a group-by operation on transactions related to data-points, according to a logical-entity into entities. Then, clustering entities of a clean-financial dataset into clusters. Selecting data-points of: (a) entities from the clusters to a first dataset and (b) a preconfigured amount of entities randomly to a second dataset. Selecting all entities that have at least one ‘fraudulent’ data-points in at least one related data-point to add all the entities to the first dataset and the second dataset. Using vectorized and scaled extracted features for training a first machine-learning-model of fraud detection on the first dataset and training a second machine-learning-model of fraud detection on the second dataset to collect results.

Abstract: A risk-prediction-preparation module to generate a risk-prediction-model, is provided herein. The risk-prediction-preparation module includes accessing a data-storage of transactions to operate a group-by operation on transactions related to data-points, according to a logical-entity into entities. Then, clustering entities of a clean-financial dataset into clusters. Selecting data-points of: (a) entities from the clusters to a first dataset and (b) a preconfigured amount of entities randomly to a second dataset. Selecting all entities that have at least one ‘fraudulent’ data-points in at least one related data-point to add all the entities to the first dataset and the second dataset. Using vectorized and scaled extracted features for training a first machine-learning-model of fraud detection on the first dataset and training a second machine-learning-model of fraud detection on the second dataset to collect results.

Abstract: A method of preventing or treating a disease characterized by an excessive immune response in a subject in need thereof is provided. The method includes administering to the subject a composition including an active component, wherein the active component is a first compound, a second compound, a third compound, a pharmaceutically acceptable salt thereof, a solvate thereof, or a combination thereof, wherein the first, second, and third compounds include: respectively.

Abstract: A method of preventing or treating a disease characterized by an excessive immune response in a subject in need thereof is provided. The method includes administering to the subject a composition including an active component, wherein the active component is a first compound, a second compound, a third compound, a pharmaceutically acceptable salt thereof, a solvate thereof, or a combination thereof, wherein the first, second, and third compounds include: respectively.

Abstract: The present invention relates to a compound or a pharmaceutically acceptable salt thereof or a solvate thereof or a pharmaceutical composition comprising said compound, a process for obtaining or screening for a toll-like receptor 9 (TLR9) antagonist and a toll-like receptor 9 (TLR9) antagonist or a pharmaceutically acceptable salt thereof or a solvate thereof, preferably being obtainable thereby.