Patents by Inventor Marialessandra Contino

Marialessandra Contino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tetrahydroisoquinoline compounds for use in the diagnosis and treatment of neurodegenerative diseases
    Patent number: 9095631
    Abstract: The invention relates to a new class of compounds with high affinity and selectivity towards P-glycoprotein. The invention also relates to the utilization of such compounds in the in vivo diagnosis of neurodegenerative diseases and as medicaments for use in the prevention and treatment of neurodegenerative disease involving P-glycoprotein.
    Type: Grant
    Filed: May 24, 2011
    Date of Patent: August 4, 2015
    Assignee: UNIVERSITA DEGLI STUDI DI BARI “ALDO MORO”
    Inventors: Nicola Antonio Colabufo, Francesco Berardi, Mariangela Cantore, Marialessandra Contino, Marcello Leopoldo, Roberto Perrone
  • NOVEL TETRAHYDROISOQUINOLINE COMPOUNDS FOR USE IN THE DIAGNOSIS AND TREATMENT OF NEURODEGENERATIVE DISEASES
    Publication number: 20140112868
    Abstract: The invention relates to a new class of compounds with high affinity and selectivity towards P-glycoprotein. The invention also relates to the utilization of such compounds in the in vivo diagnosis of neurodegenerative diseases and as medicaments for use in the prevention and treatment of neurodegenerative disease involving P-glycoprotein.
    Type: Application
    Filed: May 24, 2011
    Publication date: April 24, 2014
    Applicant: UNIVERSITA' DEGLI STUDI DI BARI "ALDO MORO"
    Inventors: Nicola Antonio Colabufo, Francesco Berardi, Mariangela Cantore, Marialessandra Contino, Marcello Leopoldo, Roberto Perrone
  • -(1,2,3,4-tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HTreceptor ligands
    Patent number: 7488730
    Abstract: A series of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides was prepared and their affinity for serotonin 5-HT7, 5-HT1A, and 5-HT2A receptors was measured using in vitro binding assays. In relation to 5-HT7 receptor affinity, receptor binding studies indicated that: (i) the optimal alkyl chain length was five methylenes; (ii) an unsubstituted 1,2,3,4-tetrahydronaphthalenyl nucleus was selected for further substitutions; and (iii) the substitution pattern of the aryl ring linked to the piperazine ring played a significant role. Several compound with high affinity for 5-HT7 receptors were identified.
    Type: Grant
    Filed: November 18, 2005
    Date of Patent: February 10, 2009
    Assignee: Universita Degli Studi Di Bari
    Inventors: Marcello Leopoldo, Francesco Berardi, Nicola Antonio Colabufo, Marialessandra Contino, Enza Lacivita, Mauro Niso, Roberto Perrone, Vincenzo Tortorella
  • N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands
    Publication number: 20070117811
    Abstract: A series of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides was prepared and their affinity for serotonin 5-HT7, 5-HT1A, and 5-HT2A receptors was measured using in vitro binding assays. In relation to 5-HT7 receptor affinity, receptor binding studies indicated that: (i) the optimal alkyl chain length was five methylenes; (ii) an unsubstituted 1,2,3,4-tetrahydronaphthalenyl nucleus was selected for further substitutions; and (iii) the substitution pattern of the aryl ring linked to the piperazine ring played a significant role. Several compound with high affinity for 5-HT7 receptors were identified.
    Type: Application
    Filed: November 18, 2005
    Publication date: May 24, 2007
    Inventors: Marcello Leopoldo, Francesco Berardi, Nicola Colabufo, Marialessandra Contino, Enza Lacivita, Mauro Niso, Roberto Perrone, Vincenzo Tortorella