Patents by Inventor Mariam GHARIBYAN

Mariam GHARIBYAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the synthesis of buprenorphine
    Patent number: 11905296
    Abstract: The present invention relates to a novel route of synthesis for the opioid receptor antagonist Buprenorphine or a pharmaceutically acceptable salt thereof, starting from thebaine, wherein the route comprises the reaction of thebaine with a dienophile; forming an alkylated reaction product by reaction with a Grignard-reagent; formation of an cyanamide; deprotection of the cyanamide- and the phenolic-oxygen-moiety, wherein the cleavage of one or both groups is performed in the presence of an alkali or alkaline earth sulfide; followed by derivatization with a cyclopropyl-halogen and hydrogenation to yield Buprenorphine.
    Type: Grant
    Filed: January 27, 2021
    Date of Patent: February 20, 2024
    Assignee: AZAD PHARMA AG
    Inventors: Hartmut Zinser, Tamar Danielyan, Meri Grigoryan, Mariam Gharibyan, Mikayel Movsisyan, Kristine Nerkararyan
  • PROCESS FOR THE SYNTHESIS OF BUPRENORPHINE
    Publication number: 20230071914
    Abstract: The present invention relates to a novel route of synthesis for the opioid receptor antagonist Buprenorphine or a pharmaceutically acceptable salt thereof, starting from thebaine, wherein the route comprises the reaction of thebaine with a dienophile; forming an alkylated reaction product by reaction with a Grignard-reagent; formation of an cyanamide; deprotection of the cyanamide- and the phenolic-oxygen-moiety, wherein the cleavage of one or both groups is performed in the presence of an alkali or alkaline earth sulfide; followed by derivatization with a cyclopropyl-halogen and hydrogenation to yield Buprenorphine.
    Type: Application
    Filed: January 27, 2021
    Publication date: March 9, 2023
    Inventors: Hartmut ZINSER, Tamar DANIELYAN, Meri GRIGORYAN, Mariam GHARIBYAN, Mikayel MOVSISYAN, Kristine NERKARARYAN