Patents by Inventor Marian L. Kruzel

Marian L. Kruzel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for treatment of symptoms associated with intracranial hemorrhage
    Patent number: 10442852
    Abstract: Methods and compositions are provided for the treatment of a patient with intracranial hemorrhage (ICH). Methods include the use of the products of recombinant constructs such as those that contain lactoferrin, as well as fusion protein constructs of lactoferrin and Fc domain for IgG.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: October 15, 2019
    Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Marian L. Kruzel, Jaroslaw Aronowski
  • METHODS AND COMPOSITIONS FOR TREATMENT OF SYMPTOMS ASSOCIATED WITH INTRACRANIAL HEMORRHAGE
    Publication number: 20180127486
    Abstract: Methods and compositions are provided for the treatment of a patient with intracranial hemorrhage (ICH). Methods include the use of the products of recombinant constructs such as those that contain lactoferrin, as well as fusion protein constructs of lactoferrin and Fc domain for IgG.
    Type: Application
    Filed: December 19, 2017
    Publication date: May 10, 2018
    Inventors: Marian L. KRUZEL, Jaroslaw ARONOWSKI
  • Purification of peptides from colostrum
    Patent number: 8168585
    Abstract: The invention relates to the purification of peptides from colostrum. The method involves the addition of an alcohol such as methanol or ethanol to the mixture in order to form an alcohol phase rich in the peptides, and a precipitate. The peptide-rich alcohol phase is subsequently recovered and subjected to further fractionation. The invention is particularly useful in the purification of colostrinin from colostrum.
    Type: Grant
    Filed: May 6, 2009
    Date of Patent: May 1, 2012
    Assignee: Regen Therapeutics PLC
    Inventors: Jerzy Alexander Georgiades, Antoni Polanowski, Tadeusz Wilusz, Marian L. Kruzel
  • THERAPEUTIC USE OF PEPTIDES
    Publication number: 20110190215
    Abstract: The amino acid sequences of peptides are disclosed.
    Type: Application
    Filed: May 15, 2009
    Publication date: August 4, 2011
    Inventor: Marian L. Kruzel
  • THERAPEUTIC USES OF COLOSTRININ
    Publication number: 20110098216
    Abstract: There is provided the use of Colostrinin for the treatment of obesity.
    Type: Application
    Filed: October 21, 2010
    Publication date: April 28, 2011
    Applicant: REGEN THERAPEUTICS PLC
    Inventors: Istvan Boldogh, Marian L. Kruzel
  • Lactoferrin for age related disorders in humans
    Patent number: 7691809
    Abstract: The method of the present invention provides a novel use of lactoferrin to modulate the molecular events during development of age-related disorders in humans. More specifically, the present invention is directed to the use of lactoferrin to treat or prevent autoimmune, neurodegenerative and immune hypersensitivity disorders, and its use for the manufacture of a medicament for the treatment or prevention of such conditions.
    Type: Grant
    Filed: January 22, 2005
    Date of Patent: April 6, 2010
    Assignee: Vitaerx Pharmaceutical, Inc.
    Inventors: Marian L. Kruzel, Tadeusz Kruzel, Michal Zimecki
  • Purification of Peptides from Colostrum
    Publication number: 20090234099
    Abstract: The invention relates to the purification of peptides from colostrum. The method involves the addition of an alcohol such as methanol or ethanol to the mixture in order to form an alcohol phase rich in the peptides, and a precipitate. The peptide-rich alcohol phase is subsequently recovered and subjected to further fractionation. The invention is particularly useful in the purification of colostrinin from colostrum.
    Type: Application
    Filed: May 6, 2009
    Publication date: September 17, 2009
    Applicant: REGEN THERAPEUTICS PLC
    Inventors: Jerzy A. Georgiades, Antoni Polanowski, Tadeusz Wilusz, Marian L. Kruzel
  • Human Glycoform
    Publication number: 20090226476
    Abstract: The present invention relates to a composition of matter consisting of fully humanized recombinant human lactoferrin (rhLF) that is capable to elicit the immune responses with respect to disease or drug-induced immune impairment in humans.
    Type: Application
    Filed: March 5, 2009
    Publication date: September 10, 2009
    Inventor: Marian L. Kruzel
  • Immune enhancing composition containing lactoferrin
    Publication number: 20030203839
    Abstract: The composition of the present invention provides a novel use of the iron binding protein lactoferrin as a medicament to prevent the progression of systemic inflammatory response syndrome (SIRS) into sepsis, severe sepsis, septic shock and multiple organ failure in mammals. More particularly, the present invention is the use of lactoferrin for the manufacture of a medicament for the treatment of the metabolic imbalance in ICU patient.
    Type: Application
    Filed: June 6, 2003
    Publication date: October 30, 2003
    Inventors: Marian L. Kruzel, Gilbert A. Castro
  • Method for treating aseptic SIRS in humans and other animals
    Patent number: 6613741
    Abstract: The method of the present invention provides a novel use of the iron binding protein lactoferrin to prevent or treat the insult-induced metabolic imbalance in humans and other animals. More particularly, the present invention is the use of lactoferrin for the manufacture of a medicament for the treatment of the metabolic hypo- or hyperactivity in the gut.
    Type: Grant
    Filed: October 29, 1999
    Date of Patent: September 2, 2003
    Assignee: Ferro Dynamics, Inc.
    Inventors: Marian L. Kruzel, Gilbert A. Castro
  • Lactoferrin for age related disorders in humans
    Publication number: 20030096736
    Abstract: The method of the present invention provides a novel use of lactoferrin to modulate the molecular events during development of autoimmune and/or neurodegenerative disorders in humans. More specifically, the present invention is directed to the use of lactoferrin to treat or prevent age related disorders such as Alzheimer's disease, multiple sclerosis, rheumatoid arthritis, stroke or chronic fatigue syndrom, and its use for the manufacture of a medicament for the treatment or prevention of such disorders.
    Type: Application
    Filed: May 7, 2002
    Publication date: May 22, 2003
    Inventors: Marian L. Kruzel, Tadeusz Kruzel, Michal Zimecki
  • Treating compositions with lactoferrin
    Publication number: 20020160941
    Abstract: Reducing the microbial contamination of a composition by treating with lactoferrin.
    Type: Application
    Filed: December 18, 2001
    Publication date: October 31, 2002
    Inventor: Marian L. Kruzel
  • Human lactoferrin
    Patent number: 6455687
    Abstract: Disclosed is human lactoferrin clone, its method of production and purification.
    Type: Grant
    Filed: August 17, 2001
    Date of Patent: September 24, 2002
    Assignee: FerraDynamics, Inc
    Inventors: Marian L. Kruzel, Darrell J. Doyle, Tomasz Kurecki, Paul D. Gollnick
  • METHODS FOR PREVENTING AND TREATING THE INSULT-INDUCED METABOLIC IMBALANCE IN HUMANS AND OTHER ANIMALS
    Publication number: 20010056067
    Abstract: The method of the present invention provides a novel use of the iron binding protein lactoferrin to prevent or treat the insult-induced metabolic imbalance in humans and other animals. More particularly, the present invention is the use of lactoferrin for the manufacture of a medicament for the treatment of the metabolic hypo- or hyperactivity in the gut.
    Type: Application
    Filed: October 29, 1999
    Publication date: December 27, 2001
    Inventors: MARIAN L. KRUZEL, GILBERT A. CASTRO
  • Human lactoferrin
    Patent number: 6277817
    Abstract: Disclosed is human lactoferrin expressed using recombinant DNA, its method of production and purification.
    Type: Grant
    Filed: October 19, 1999
    Date of Patent: August 21, 2001
    Assignee: Ferro Dynamics Inc.
    Inventors: Marian L. Kruzel, Darrell J. Doyle, Tomasz Kurecki, Paul D. Gollnick
  • Cloning, expression, and uses of human lactoferrin
    Patent number: 6066469
    Abstract: Disclosed is human lactoferrin expressed using recombinant DNA, its method of production and purification.
    Type: Grant
    Filed: September 30, 1996
    Date of Patent: May 23, 2000
    Assignee: Ferro Dynamics, Inc.
    Inventors: Marian L. Kruzel, Tomasz Kurecki, Paul D. Gollnick, Darrell J. Doyle
  • Iron detecting sensors
    Patent number: 5925318
    Abstract: The present invention is directed to iron sensors. Immobilized in close proximity of the potential or pH measuring surface of a proton sensing device, minute quantities of an iron chelator such as siderophores or transferring cause detectable variation of the potential or pH upon the binding of iron. The sensing devices for measuring this change in potential or pH include the iron chelator-modified ion-selective field effect transistors (IC-ISFET) and/or pH indicator papers of the present invention.
    Type: Grant
    Filed: May 13, 1996
    Date of Patent: July 20, 1999
    Assignee: Ferro Sensor, Inc.
    Inventors: Marian L. Kruzel, Kurt S. Myers
  • Biosensor for detecting iron
    Patent number: 5516697
    Abstract: A simple, cost effective assay of iron is accomplished by using lactoferrin as part of a biosensor to detect iron in a sample. The lactoferrin releases protons when the iron is sequestered by the lactoferrin and the change in potential caused by the release of protons is measured by a potentiometer or pH sensing device. The sensing devices include the ion-selective or ion sensitive field effect transistors (ISFET), a potentiometric device or the pH indicator papers.
    Type: Grant
    Filed: August 9, 1995
    Date of Patent: May 14, 1996
    Assignee: Ferrosensor, Inc.
    Inventor: Marian L. Kruzel