Patents by Inventor Marian Orlowski

Marian Orlowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Potent and specific immunoproteasome inhibitors
    Patent number: 7589066
    Abstract: Compounds and methods of selectively inhibiting an immunoproteasome are described. Also described are methods of treating a cancer, an inflammation, and/or an autoimmune disease and methods of suppressing endogenous antigenic peptide generation by administering to a subject in need of treatment thereof a therapeutic amount of an immunoproteasome specific inhibitor.
    Type: Grant
    Filed: March 13, 2006
    Date of Patent: September 15, 2009
    Assignees: The University of North Carolina at Chapel Hill, Mount Sinai School of Medicine of New York University
    Inventors: Robert Z. Orlowski, Marian Orlowski
  • Potent and specific immunoproteasome inhibitors
    Publication number: 20060241056
    Abstract: Compounds and methods of selectively inhibiting an immunoproteasome are described. Also described are methods of treating a cancer, an inflammation, and/or an autoimmune disease and methods of suppressing endogenous antigenic peptide generation by administering to a subject in need of treatment thereof a therapeutic amount of an immunoproteasome specific inhibitor.
    Type: Application
    Filed: March 13, 2006
    Publication date: October 26, 2006
    Inventors: Robert Orlowski, Marian Orlowski
  • Substrate-related peptidyl-aldehyde inhibitors of the proteolytic activity of the multicatalytic proteinase complex
    Patent number: 5580854
    Abstract: The present invention provides novel peptidylaldehyde inhibitors of proteolysis mediated by the multicatalytic proteinase complex (MPC) or proteasome. The inhibitors have the general formulaZ-P.sub.4 -P.sub.3 -P.sub.2 -P.sub.1 -CHO (I)whereinP.sub.1 is selected from among branched chain amino acids occurring naturally in proteins and norleucine;P.sub.2 is selected from among non-polar L-amino acids;P.sub.3 is proline or hydroxyproline;P.sub.4 is selected from among non-polar L-amino acids;CHO is an aldehyde replacement for the COOH group on the P.sub.1 amino acid; andZ is an amino blocking group attached to the NH.sub.2 group on the P.sub.4 amino acid.The amino blocking group Z may be chosen from among benzyloxycarbonyl, benzoylglycine, tertiary butoxycarbonyl, acetylbenzyloxycarbonyl, benzoylglycine, tertiary butoxycarbonyl, acetyl or other NH.sub.2 blocking groups known in protein and peptide chemistry.
    Type: Grant
    Filed: March 4, 1994
    Date of Patent: December 3, 1996
    Assignee: Mount Sinai School of Medicine of The City University of New York
    Inventors: Marian Orlowski, Christopher Cardozo, Alexander Vinitsky
  • Synthesis and use of L-.gamma.-glutamyl-DOPA
    Patent number: 4125626
    Abstract: The synthesis of L-.gamma.-glutamyl-DOPA (L-.gamma.-glutamyl-L-3,4-dihydroxy-phenylalanine) and its use selectively to increase renal blood flow in mammals.
    Type: Grant
    Filed: January 17, 1977
    Date of Patent: November 14, 1978
    Assignee: Mt. Sinai School of Medicine of the City University of New York
    Inventors: Marian Orlowski, Sherwin Wilk