Patents by Inventor Mariana Brait

Mariana Brait has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ovarian Cancer Methylome
    Publication number: 20160201140
    Abstract: The present invention provides methods and kits for identifying a cell that exhibits or is predisposed to exhibiting unregulated growth by detecting hypennethylation of a gene or a regulatory region in at least one gene in the cell. Also provided are methods for diagnosis or prognosis of ovarian cancer in a subject. Also provided are methods of ameliorating ovarian cancer in a subject by administering to the subject an agent that demethylates a hypermethylated gene or regulatory region thereof.
    Type: Application
    Filed: November 16, 2015
    Publication date: July 14, 2016
    Inventors: Mohommad O. Hoque, Mariana Brait, Leonel Maldonado
  • Ovarian cancer methylome
    Patent number: 9187786
    Abstract: The present invention provides methods and kits for identifying a cell that exhibits or is predisposed to exhibiting unregulated growth by detecting hypermethylation of a gene or a regulatory region in at least one gene in the cell. Also provided are methods for diagnosis or prognosis of ovarian cancer in a subject. Also provided are methods of ameliorating ovarian cancer in a subject by administering to the subject an agent that demethylates a hypermethylated gene or regulatory region thereof.
    Type: Grant
    Filed: February 26, 2010
    Date of Patent: November 17, 2015
    Assignee: The Johns Hopkins University
    Inventors: Mohammad O. Hoque, Mariana Brait, Leonel Maldonado
  • Ovarian Cancer Methylome
    Publication number: 20120014871
    Abstract: The present invention provides methods and kits for identifying a cell that exhibits or is predisposed to exhibiting unregulated growth by detecting hypermethylation of a gene or a regulatory region in at least one gene in the cell. Also provided are methods for diagnosis or prognosis of ovarian cancer in a subject. Also provided are methods of ameliorating ovarian cancer in a subject by administering to the subject an agent that demethylates a hypermethylated gene or regulatory region thereof.
    Type: Application
    Filed: February 26, 2010
    Publication date: January 19, 2012
    Inventors: Mohammad O. Hoque, Mariana Brait, Leonel Maldonado