Abstract: Disclosed are macroscopic systems of highly concentrated, cross-linked biopolymers. The macroscopic system is created by combining a biopolymer with a cross-linking agent, submerging the resulting product in an aqueous solution which contains additional cross-linking agents, to allow the biopolymer to undergo a second cross-linking process. The resulting macroscopic biopolymer has an increased biopolymer concentration and increased longevity within the body.

Abstract: The present invention discloses methods for manufacturing drug delivery composition comprising at least one pharmaceutically active compound, at least one anti-caking agent and at least one oil. The anti-caking agent and the oil form the matrix when mixed, which then embeds the pharmaceutically active compound.

Abstract: Disclosed are micronized hydrophilic systems of highly concentrated, cross-linked biopolymers. The system is created by combining a biopolymer with a cross-linking agent under mechanical kneading and allowing the biopolymer to undergo a cross-linking process followed by purification, drying and milling. The resulting micronized biopolymer system has an increased biopolymer concentration and increased longevity within the body.

Abstract: A drug-delivery composition includes an intermediate composition having a hydrophilic matrix of a cross-linked polymer in form of particles, and a pharmaceutically active composition distributed in the cross-linked polymer of the particles.