Patents by Inventor Mariane LE FUR

Mariane LE FUR has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • THERAPEUTIC, RADIOLABELED NANOPARTICLES AND METHODS OF USE THEREOF
    Publication number: 20230398243
    Abstract: Provided herein are therapeutic nanoparticles including a radiolabel, a chelator that is covalently linked to the therapeutic nanoparticle and to the radiolabel, and a nucleic acid molecule that is covalently linked to the therapeutic nanoparticle. The therapeutic nanoparticle has a diameter between about 10 nanometers (nm) to about 30 nm, and the therapeutic nanoparticle is magnetic. Also provided are pharmaceutical compositions containing these therapeutic nanoparticles. Also provided herein are methods of decreasing cancer cell invasion or metastasis in a subject having a cancer and methods of treating a metastatic cancer in a lymph node in a subject that require the administration of these therapeutic nanoparticles to a subject. Also provided herein are methods of detecting, diagnosing, and/or monitoring a metastatic cancer tissue in a subject. Also provided herein are methods of preparing these therapeutic nanoparticles.
    Type: Application
    Filed: November 3, 2021
    Publication date: December 14, 2023
    Inventors: Zdravka Medarova, Sergey Shuvaev, Peter Caravan, Mariane Le Fur, Byunghee Yoo
  • Reinforced macrocyclic ligands, complexes thereof, and uses of same
    Patent number: 11155553
    Abstract: Ligands that are based on the pyclen macrocycle that are reinforced, which are useful for complexing elements such as radioelements and/or elements with magnetic properties.
    Type: Grant
    Filed: June 28, 2018
    Date of Patent: October 26, 2021
    Assignees: GUERBET, UNIVERSITE DE BRETAGNE OCCIDENTALE, Centre national de la recherche scientifique
    Inventors: Raphaël Tripier, Olivier Rousseaux, Mariane Le Fur, Maryline Beyler, Olivier Fougère, Gwladys Nizou
  • Macrocyclic ligands with picolinate group(s), complexes thereof and also medical uses thereof
    Patent number: 10981912
    Abstract: A macrocycle compound of general formula (X) in which Y1 represents a C(O)OH group or a group of formula (II)
    Type: Grant
    Filed: October 21, 2019
    Date of Patent: April 20, 2021
    Assignees: GUERBET, UNIVERSITE DE BRETAGNE OCCIDENTALE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Mariane Le Fur, Raphaël Tripier, Olivier Rousseaux, Maryline Beyler
  • Macrocylic ligands with picolinate group(s), complexes thereof and also medical uses thereof
    Patent number: 10711001
    Abstract: The present invention relates to compounds, ligands, and/or complexes that are useful in medical imaging and/or in therapy, especially in cancer treatment. The present invention also relates to a pharmaceutical composition comprising said compounds, ligands, and/or complexes that are useful for medical imaging, targeting, and/or treatment of cancers. The present invention also relates to a process for preparing these compounds, ligands, and/or complexes.
    Type: Grant
    Filed: December 23, 2016
    Date of Patent: July 14, 2020
    Assignees: GUERBET, UNIVERSITE DE BRETAGNE OCCIDENTALE, CENTRAL NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Mariane Le Fur, Raphaël Tripier, Olivier Rousseaux, Maryline Beyler
  • REINFORCED MACROCYCLIC LIGANDS, COMPLEXES THEREOF, AND USES OF SAME
    Publication number: 20200157101
    Abstract: Ligands that are based on the pyclen macrocycle that are reinforced, which are useful for complexing elements such as radioelements and/or elements with magnetic properties.
    Type: Application
    Filed: June 28, 2018
    Publication date: May 21, 2020
    Inventors: Raphaël TRIPIER, Olivier ROUSSEAUX, Mariane LE FUR, Maryline BEYLER, Olivier FOUGÈRE, Gwladys NIZOU
  • MACROCYCLIC LIGANDS WITH PICOLINATE GROUP(S), COMPLEXES THEREOF AND ALSO MEDICAL USES THEREOF
    Publication number: 20200123155
    Abstract: A macrocycle compound of general formula (X) in which Y1 represents a C(O)OH group or a group of formula (II)
    Type: Application
    Filed: October 21, 2019
    Publication date: April 23, 2020
    Inventors: Mariane Le Fur, Raphaël Tripier, Olivier Rousseaux, Maryline Beyler
  • MACROCYLIC LIGANDS WITH PICOLINATE GROUP(S), COMPLEXES THEREOF AND ALSO MEDICAL USES THEREOF
    Publication number: 20190023705
    Abstract: The present invention relates to compounds, ligands, and/or complexes that are useful in medical imaging and/or in therapy, especially in cancer treatment. The present invention also relates to a pharmaceutical composition comprising said compounds, ligands, and/or complexes that are useful for medical imaging, targeting, and/or treatment of cancers. The present invention also relates to a process for preparing these compounds, ligands, and/or complexes.
    Type: Application
    Filed: December 23, 2016
    Publication date: January 24, 2019
    Inventors: Mariane LE FUR, Raphaël TRIPIER, Olivier ROUSSEAUX, Maryline BEYLER